Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

2017 ◽  
Vol 15 (48) ◽  
pp. 10289-10298 ◽  
Author(s):  
Kapil Mohan Saini ◽  
Rakesh K. Saunthwal ◽  
Akhilesh K. Verma
Keyword(s):  
Palladium Catalyst ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Arylboronic Acid ◽  
One Pot ◽  
Cross Coupling Reactions ◽  
Sterically Hindered

Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromothiophene with arylboronic acid and an alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium catalyst were described.

A Revised Modular Approach to D8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions

2019 ◽  
Author(s):  
Victor Bloemendal ◽  
Floris P. J. T. Rutjes ◽  
Thomas J. Boltje ◽  
Daan Sondag ◽  
Hidde Elferink ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Medicinal Chemistry ◽  
Cross Coupling ◽  
Modular Approach ◽  
Coupling Reactions ◽  
One Pot ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Chemistry Research

<p>In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-<i>trans</i>-Δ<sup>8</sup>-THC derivatives, which can be used to modulate the pharmacologically important CB<sub>1</sub> and CB<sub>2</sub> receptors. This pathway involves a one-pot Friedel-Crafts alkylation/cyclization protocol, followed by Suzuki-Miyaura cross-coupling reactions and gives rise to a series of new Δ<sup>8</sup>-THC derivatives. In addition, we demonstrate using extensive NMR evidence that similar halide-substituted Friedel-Crafts alkylation/cyclization products in previous articles were wrongly assigned as the para-isomers, which also has consequence for the assignment of the subsequent cross-coupled products and interpretation of their biological activity. </p> <p>Considering the importance of the availability of THC derivatives in medicinal chemistry research and the fact that previously synthesized compounds were wrongly assigned, we feel this research is describing a straightforward pathway into new cannabinoids.</p>

Direct Synthesis of Palladium Catalyst on Supporting WS2Nanotubes and its Reactivity in Cross-Coupling Reactions

2015 ◽  
Vol 10 (10) ◽  
pp. 2234-2239 ◽  
Author(s):  
Bojana Višić ◽  
Hagai Cohen ◽  
Ronit Popovitz-Biro ◽  
Reshef Tenne ◽  
Viacheslav I. Sokolov ◽  
...  
Keyword(s):  
Palladium Catalyst ◽  
Direct Synthesis ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Pyridinyl functionalized MCM-48 supported highly active heterogeneous palladium catalyst for cross-coupling reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19630-19637 ◽  
Author(s):  
Shaheen M. Sarkar ◽  
Md. Lutfor Rahman ◽  
Mashitah Mohd Yusoff
Keyword(s):  
Palladium Catalyst ◽  
Cross Coupling ◽  
Significant Loss ◽  
Pd Catalyst ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Highly Active ◽  
Supported Pd ◽  
Heterogeneous Palladium Catalyst

Pyridinyl functionalized MCM-48-supported Pd-catalyst efficiently (0.013–0.025 mol%) promoted Heck, Suzuki and Sonogashira cross-coupling reactions. Moreover, the catalyst was reused five times without significant loss of its activity.

scholarly journals Synthesis of pentasubstituted 2-aryl pyrroles from boryl and stannyl alkynes via one-pot sequential Ti-catalyzed [2 + 2 + 1] pyrrole synthesis/cross coupling reactions

2020 ◽  
Vol 11 (37) ◽  
pp. 10236-10242
Author(s):  
Yukun Cheng ◽  
Channing K. Klein ◽  
Ian A. Tonks
Keyword(s):  
Small Molecule ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions

Multisubstituted pyrroles are commonly found in many bioactive small molecule scaffolds, yet the synthesis of highly-substituted pyrrole cores remains challenging.

Synthesis of Di-, Tri-, and Tetrasulfides through Multifold Carbon−Sulfur Cross-Coupling Reactions with Indium Tri(organothiolates) in a One-Pot Procedure

2011 ◽  
Vol 76 (3) ◽  
pp. 760-765 ◽  
Author(s):  
Phil Ho Lee ◽  
Youngchul Park ◽  
Sangkyun Park ◽  
Euijae Lee ◽  
Sunggak Kim
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions
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