A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery

2018 ◽  
Vol 9 (2) ◽  
pp. 169-177 ◽  
Author(s):  
Hongliang Cao ◽  
Chao Chen ◽  
Debiao Xie ◽  
Xin Chen ◽  
Ping Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Ph Sensitive ◽  
Amphiphilic Block Copolymer ◽  
Atom Transfer ◽  
Smart Drug ◽  
Smart Drug Delivery

In this study, a novel hyperbranched amphiphilic block copolymer was synthesized using deactivation-enhanced atom transfer radical polymerization (DE-ATRP) for smart drug delivery.

Synthesis of Biotinylated pH-Sensitive Glycopolymer with Different Architectures

2017 ◽  
Vol 898 ◽  
pp. 2373-2377
Author(s):  
Zhong Li Niu ◽  
Shu Yu Zhu ◽  
Xiao Ting Zhang ◽  
Xiao Ze Jiang ◽  
Mei Fang Zhu
Keyword(s):  
Nmr Spectroscopy ◽  
Controlled Release ◽  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Ph Sensitive ◽  
Atom Transfer ◽  
Ph Response

Two pH-sensitive Glycopolymers with the same components but with different construction tailored biotin functionalities were developed for controlled release of bortezomib (BTZ).The initiator brominate biotin and glyco-monomer were synthesized precedently to produce the block-and random-biotinylated poly (2-Gluconamidoethyl methacrylate)-poly (2-Diethylaminoethyl methacrylate) (block/random Biotin-PGAMA-PDEA) via atom transfer radical polymerization (ATRP). The construction and composition of compounds and polymers were characterized by 1H NMR Spectroscopy. The block copolymer self-assembled into micelle according to the pH-response ability of the copolymer while the random one did not under certain conditions.

ATRP Synthesis of PS-b-PtBMA and Preparation of Porous Film

2013 ◽  
Vol 364 ◽  
pp. 679-683
Author(s):  
Chang Hao Yan ◽  
Zhi Jiao Zhang ◽  
Hai Yan Chen ◽  
Zhong Yi Xie ◽  
Ting Zhu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Catalyst System ◽  
Porous Film ◽  
Atom Transfer ◽  
H Nmr ◽  
Breath Figure ◽  
Breath Figure Method ◽  
End Group

The polystyrene with end group of Br was synthesized by using MBrP as the initiator, CuBr/ PMDETA as the catalyst system according to atom transfer radical polymerization (ATRP). The effect of reaction temperature was studied and the system was confirmed as the active polymerization. Then PS-Br and CuBr/ PMDETA were respectively used as macroinitiator and catalyst to polymerize tBMA according to atom transfer radical polymerization (ATRP). The structure of the product was characterized by GPCFTIR1H-NMR. The amphiphilic block copolymer was obtained after hydrolysis. And the honeycomb porous film was prepared by PS-b-PMAA through using breath figure method.

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