Amphiphilic block copolymer of SN38 prodrugs by atom transfer radical polymerization: Synthesis, kinetic studies and self-assembly

2015 ◽  
Vol 213 ◽  
pp. e124 ◽  
Author(s):  
Xun Liu ◽  
Jinqiang Wang ◽  
Youqing Shen ◽  
Jianbin Tang ◽  
Meihua Sui
Keyword(s):  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Self Assembly ◽  
Kinetic Studies ◽  
Amphiphilic Block Copolymer ◽  
Atom Transfer

A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery

2018 ◽  
Vol 9 (2) ◽  
pp. 169-177 ◽  
Author(s):  
Hongliang Cao ◽  
Chao Chen ◽  
Debiao Xie ◽  
Xin Chen ◽  
Ping Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Ph Sensitive ◽  
Amphiphilic Block Copolymer ◽  
Atom Transfer ◽  
Smart Drug ◽  
Smart Drug Delivery

In this study, a novel hyperbranched amphiphilic block copolymer was synthesized using deactivation-enhanced atom transfer radical polymerization (DE-ATRP) for smart drug delivery.

Design, postpolymerization conjugation and self-assembly of a di-block copolymer-based prodrug for tumor intracellular acid-triggered DOX release

2019 ◽  
Vol 7 (37) ◽  
pp. 5640-5647 ◽  
Author(s):  
Yuman Dong ◽  
Pengcheng Du ◽  
Mingliang Pei ◽  
Peng Liu
Keyword(s):  
Polyethylene Glycol ◽  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Self Assembly ◽  
Glycidyl Methacrylate ◽  
Atom Transfer ◽  
Imine Bond ◽  
Acid Labile ◽  
Intracellular Acid

A novel di-block copolymer-based prodrug was designed by atom transfer radical polymerization (ATRP) of glycidyl methacrylate (GMA) with a polyethylene glycol-based initiator (PEG-Br), postpolymerization aldehyde-modification, and doxorubicin (DOX) conjugation via an acid-labile imine bond.

ATRP Synthesis of PS-b-PtBMA and Preparation of Porous Film

2013 ◽  
Vol 364 ◽  
pp. 679-683
Author(s):  
Chang Hao Yan ◽  
Zhi Jiao Zhang ◽  
Hai Yan Chen ◽  
Zhong Yi Xie ◽  
Ting Zhu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Catalyst System ◽  
Porous Film ◽  
Atom Transfer ◽  
H Nmr ◽  
Breath Figure ◽  
Breath Figure Method ◽  
End Group

The polystyrene with end group of Br was synthesized by using MBrP as the initiator, CuBr/ PMDETA as the catalyst system according to atom transfer radical polymerization (ATRP). The effect of reaction temperature was studied and the system was confirmed as the active polymerization. Then PS-Br and CuBr/ PMDETA were respectively used as macroinitiator and catalyst to polymerize tBMA according to atom transfer radical polymerization (ATRP). The structure of the product was characterized by GPCFTIR1H-NMR. The amphiphilic block copolymer was obtained after hydrolysis. And the honeycomb porous film was prepared by PS-b-PMAA through using breath figure method.

Sign in / Sign up

Export Citation Format

Share Document