scholarly journals Facile complexation reactions for the selective spectrofluorimetric determination of albendazole in oral dosage forms and spiked human plasma

RSC Advances ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 5373-5381 ◽  
Author(s):  
Ahmed A. Hamad ◽  
Ramadan Ali ◽  
Hassan Refat H. Ali ◽  
Dalia M. Nagy ◽  
Sayed M. Derayea
Keyword(s):  
Human Plasma ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Native Fluorescence ◽  
Spiked Human Plasma ◽  
Erythrosine B ◽  
Spectrofluorimetric Determination ◽  
Complexation Reactions ◽  
Oral Dosage Forms

Complexation of albendazole with erythrosine B quench the native fluorescence of the dye while complexation of the drug with lanthanum (iii) ions enhance the fluorescence of the drug.

Enhanced spectrofluorimetric determination of esomeprazole and pantoprazole in dosage forms and spiked human plasma using organized media

Luminescence ◽  
2014 ◽  
Vol 30 (3) ◽  
pp. 343-351 ◽  
Author(s):  
Fathalla Belal ◽  
Mohie Sharaf EL-Din ◽  
Manar M. Tolba ◽  
Heba Alaa
Keyword(s):  
Human Plasma ◽  
Dosage Forms ◽  
Spiked Human Plasma ◽  
Spectrofluorimetric Determination ◽  
Organized Media

Green Sensitive Spectrofluorimetric determination of Remdesvir, an FDA approved SARS-COV-2 Candidate Antiviral; Application in Pharmaceutical Dosage Forms and Spiked Human Plasma

2021 ◽  
Author(s):  
Heba Elmansi ◽  
Adel Ehab Ibrahim ◽  
Ibraam Mikhail ◽  
Fathalla Belal
Keyword(s):  
Quality Control ◽  
Human Plasma ◽  
Dosage Forms ◽  
Analytical Performance ◽  
Pharmaceutical Dosage Forms ◽  
Spiked Human Plasma ◽  
Fluorescent Spectroscopy ◽  
Spectrofluorimetric Determination

Fluorescent Spectroscopy has gained lots of interests pending the last years. Its advantages cover both; the analytical performance, as well as ecological greenness. The quality control of pharmaceuticals requires sensitive,...

Spectrofluorimetric Determination of Terbinafine Hydrochloride and Linezolid in their Dosage Forms and Human Plasma

2013 ◽  
Vol 23 (5) ◽  
pp. 1077-1087 ◽  
Author(s):  
F. Belal ◽  
M. K. Sharaf El-Din ◽  
M. I. Eid ◽  
R. M. El-Gamal
Keyword(s):  
Human Plasma ◽  
Dosage Forms ◽  
Terbinafine Hydrochloride ◽  
Spectrofluorimetric Determination

scholarly journals Spectrofluorimetric Determination of Warfarin Sodium by Using N1-Methylnicotinamide Chloride as a Fluorigenic Agent

2005 ◽  
Vol 88 (2) ◽  
pp. 455-461 ◽  
Author(s):  
Mohamed A El Dawy ◽  
Mokhtar M Mabrouk ◽  
Riad A El Barbary
Keyword(s):  
Aqueous Solutions ◽  
Human Plasma ◽  
Plasma Samples ◽  
Spiked Human Plasma ◽  
Human Plasma Samples ◽  
Warfarin Sodium ◽  
Spectrofluorimetric Method ◽  
Spectrofluorimetric Determination ◽  
Methylene Groups

Abstract A spectrofluorimetric method is described for the determination of drugs containing active methylene groups adjacent to carbonyl groups. The method was applied successfully to the determination of warfarin sodium in laboratory-prepared mixtures, in commercial tablets, and in spiked human plasma samples. Finally, the method was applied to the determination of the steady-state concentration of warfarin sodium in the blood of a hospitalized patient. The method involves the reaction of warfarin sodium with 0.2 ml (0.4 × 10−3M) N1-methylnicotinamide chloride reagent in the presence of 3 mL 1.0N NaOH and cooling in ice for 8 min, followed by adjustment of the pH to 2.0, using formic acid and heating for 4 min, whereby a highly fluorescent reaction product is produced. The optimal wavelengths of excitation and emission were determined by using a synchronous wavelength search and found to be 284 and 354 nm, respectively. The standard curves were linear over a concentration range of 50–1500 ng/mL in both aqueous solutions and spiked human plasma samples. The mean recoveries (± standard deviation) were 101.157 (±1.33) and 95.73 (±1.88%) for aqueous solutions and spiked human plasma samples, respectively. The method showed good specificity and precision. The proposed method is simple and economical because of its minimal instrumentation and chemicals requirements. Nevertheless, it is highly sensitive, specific, and reproducible. Accordingly, it is suitable for quality-control applications, drug monitoring, and bioavailability and bioequivalency studies.

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