Gadolinium-based nanoscale MRI contrast agents for tumor imaging

2017 ◽  
Vol 5 (19) ◽  
pp. 3431-3461 ◽  
Author(s):  
Yi Cao ◽  
Lijun Xu ◽  
Ye Kuang ◽  
Dangsheng Xiong ◽  
Renjun Pei
Keyword(s):  
Contrast Agents ◽  
Tumor Imaging ◽  
Region Of Interest ◽  
Mri Contrast Agents ◽  
Tumor Diagnosis ◽  
Mri Contrast ◽  
Longitudinal Relaxivity

Gadolinium-based nanoscale MRI CAs have been considered as a promising nanoplatform for tumor diagnosis, due to their favorable capability of enhancing the longitudinal relaxivity (r1) of individual gadolinium ions, delivering to the region of interest a large number of gadolinium ions, and incorporating different functionalities.

An Albumin-Binding T1–T2 Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging

2019 ◽  
Vol 30 (6) ◽  
pp. 1821-1829 ◽  
Author(s):  
Zijian Zhou ◽  
Ruiliang Bai ◽  
Zhantong Wang ◽  
Henry Bryant ◽  
Lixin Lang ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Albumin Binding ◽  
Mri Contrast

scholarly journals Genetic encoding of targeted MRI contrast agents for in vivo tumor imaging

2019 ◽  
Author(s):  
Simone Schuerle ◽  
Maiko Furubayashi ◽  
Ava P. Soleimany ◽  
Tinotenda Gwisai ◽  
Wei Huang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Contrast Effects ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Mri

AbstractTumor-selective contrast agents have the potential to aid in the diagnosis and treatment of cancer using noninvasive imaging modalities such as magnetic resonance imaging (MRI). Such contrast agents can consist of magnetic nanoparticles incorporating functionalities that respond to cues specific to tumor environments. Genetically engineering magnetotactic bacteria to display peptides has been investigated as a means to produce contrast agents that combine the robust image contrast effects of magnetosomes with transgenic targeting peptides displayed on their surface. This work reports the first use of magnetic nanoparticles that display genetically-encoded pH low insertion peptide (pHLIP), a long peptide intended to enhance MRI contrast by targeting the extracellular acidity associated with the tumors. To demonstrate the modularity of this versatile platform to incorporate diverse targeting ligands by genetic engineering, we also incorporated the cyclic αv integrin-binding peptide iRGD into separate magnetosomes. Specifically, we investigate their potential for enhanced binding and tumor imaging both in vitro and in vivo. Our experiments indicate that these tailored magnetosomes retain their magnetic properties, making them well-suited as T2 contrast agents, while exhibiting increased binding compared to wild-type magnetosomes.

Ultrasmall Fe@Fe3O4 nanoparticles as T1–T2 dual-mode MRI contrast agents for targeted tumor imaging

2021 ◽  
Vol 32 ◽  
pp. 102335
Author(s):  
Donglin Liu ◽  
Jiaojiao Li ◽  
Chengbin Wang ◽  
Lu An ◽  
Jiaomin Lin ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fe3o4 Nanoparticles ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Dual Mode ◽  
Mri Contrast

Cubosomes as Carriers for MRI Contrast Agents

2017 ◽  
Vol 24 (5) ◽  
pp. 470-482 ◽  
Author(s):  
Nicolas Alcaraz ◽  
Ben J. Boyd
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

scholarly journals Correction to: Magnetic Nanoparticles as MRI Contrast Agents

2021 ◽  
Vol 379 (4) ◽  
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo-Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García-Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

A correction to this paper has been published: https://doi.org/10.1007/s41061-021-00340-y

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