Ultrasmall Fe@Fe3O4 nanoparticles as T1–T2 dual-mode MRI contrast agents for targeted tumor imaging

2021 ◽  
Vol 32 ◽  
pp. 102335
Author(s):  
Donglin Liu ◽  
Jiaojiao Li ◽  
Chengbin Wang ◽  
Lu An ◽  
Jiaomin Lin ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fe3o4 Nanoparticles ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Dual Mode ◽  
Mri Contrast

scholarly journals Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode magnetic resonance imaging

2020 ◽  
Vol 11 ◽  
pp. 1000-1009
Author(s):  
Miao Qin ◽  
Yueyou Peng ◽  
Mengjie Xu ◽  
Hui Yan ◽  
Yizhu Cheng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Dual Mode ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

The multimodal magnetic resonance imaging (MRI) technique has been extensively studied over the past few years since it offers complementary information that can increase diagnostic accuracy. Simple methods to synthesize contrast agents are necessary for the development of multimodal MRI. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T 1–T 2 dual-mode MRI contrast agents were successfully designed and synthesized. In order to increase hydrophilicity and biocompatibility, the nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA). The results show that iron (Fe) and gadolinium (Gd) were homogeneously distributed throughout the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxation time analysis was performed on the images obtained from the 3.0 T scanner. The results demonstrated that r 1 and r 2 maximum values were 67.57 ± 6.2 and 24.2 ± 1.46 mM−1·s−1, respectively. In vivo T 1- and T 2-weighted images showed that FGDA nanocubes act as a dual-mode contrast agent enhancing MRI quality. Overall, these experimental results suggest that the FGDA nanocubes are interesting tools that can be used to increase MRI quality, enabling accurate clinical diagnostics.

Gadolinium-based nanoscale MRI contrast agents for tumor imaging

2017 ◽  
Vol 5 (19) ◽  
pp. 3431-3461 ◽  
Author(s):  
Yi Cao ◽  
Lijun Xu ◽  
Ye Kuang ◽  
Dangsheng Xiong ◽  
Renjun Pei
Keyword(s):  
Contrast Agents ◽  
Tumor Imaging ◽  
Region Of Interest ◽  
Mri Contrast Agents ◽  
Tumor Diagnosis ◽  
Mri Contrast ◽  
Longitudinal Relaxivity

Gadolinium-based nanoscale MRI CAs have been considered as a promising nanoplatform for tumor diagnosis, due to their favorable capability of enhancing the longitudinal relaxivity (r1) of individual gadolinium ions, delivering to the region of interest a large number of gadolinium ions, and incorporating different functionalities.

An Albumin-Binding T1–T2 Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging

2019 ◽  
Vol 30 (6) ◽  
pp. 1821-1829 ◽  
Author(s):  
Zijian Zhou ◽  
Ruiliang Bai ◽  
Zhantong Wang ◽  
Henry Bryant ◽  
Lixin Lang ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Albumin Binding ◽  
Mri Contrast

scholarly journals Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as T1 MRI Contrast Agents

Nanomaterials ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 699 ◽  
Author(s):  
Cheng Tao ◽  
Yanan Chen ◽  
Danli Wang ◽  
Yu Cai ◽  
Qiang Zheng ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fe3o4 Nanoparticles ◽  
Mri Contrast Agents ◽  
Hydroxyl Groups ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Cell Viability Assay ◽  
Mri Contrast ◽  
T1 Contrast ◽  
Magnetic Fe3o4 Nanoparticles ◽  
Magnetic Fe3o4

Considerable efforts have been focused on the exploitation of macromolecule ligands for synthesis of magnetic Fe3O4 nanoparticles as T1 magnetic resonance imaging (MRI) contrast agents, but studies that concern macromolecule ligands with different charges and coordination groups are still limited. Herein, we used poly(acrylic acid) (PAA), poly(allylamine hydrochloride) (PAH), and polyvinyl alcohol (PVA), which possess negative, positive and neutral charges with carboxylic acid, amino and hydroxyl groups respectively, as templates and stabilizers to fabricate Fe3O4 nanoparticles through coprecipitation reaction. The obtained Fe3O4-PAA, Fe3O4-PAH, and Fe3O4-PVA nanoparticles showed T1 contrast performance with r1 relaxivities of 23.4, 60.3, and 30.6 mM s−1 at 0.5 T (25 °C), and a r2/r1 ratio of 2.62, 3.82, and 7.26, respectively. The cell viability assay revealed that Fe3O4-PAA and Fe3O4-PVA exhibited good biocompatibility, while Fe3O4-PAH displayed high cytotoxicity. In vivo T1-weighted (1 T) mice showed that both Fe3O4-PAA and Fe3O4-PVA were able to display remarkably brighten the contrast enhancement for the mice tumor and kidney sites, but Fe3O4-PAA had better contrast performance. This work highlights that the macromolecule ligands play an important role in the biocompatibility and T1 contrast performance of magnetic Fe3O4 nanoparticles.

scholarly journals Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics

Theranostics ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 92-108 ◽  
Author(s):  
Lipeng Gao ◽  
Jing Yu ◽  
Yang Liu ◽  
Jinge Zhou ◽  
Lei Sun ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Dual Mode ◽  
Mri Contrast ◽  
Tumor Theranostics

scholarly journals Genetic encoding of targeted MRI contrast agents for in vivo tumor imaging

2019 ◽  
Author(s):  
Simone Schuerle ◽  
Maiko Furubayashi ◽  
Ava P. Soleimany ◽  
Tinotenda Gwisai ◽  
Wei Huang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Contrast Effects ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Mri

AbstractTumor-selective contrast agents have the potential to aid in the diagnosis and treatment of cancer using noninvasive imaging modalities such as magnetic resonance imaging (MRI). Such contrast agents can consist of magnetic nanoparticles incorporating functionalities that respond to cues specific to tumor environments. Genetically engineering magnetotactic bacteria to display peptides has been investigated as a means to produce contrast agents that combine the robust image contrast effects of magnetosomes with transgenic targeting peptides displayed on their surface. This work reports the first use of magnetic nanoparticles that display genetically-encoded pH low insertion peptide (pHLIP), a long peptide intended to enhance MRI contrast by targeting the extracellular acidity associated with the tumors. To demonstrate the modularity of this versatile platform to incorporate diverse targeting ligands by genetic engineering, we also incorporated the cyclic αv integrin-binding peptide iRGD into separate magnetosomes. Specifically, we investigate their potential for enhanced binding and tumor imaging both in vitro and in vivo. Our experiments indicate that these tailored magnetosomes retain their magnetic properties, making them well-suited as T2 contrast agents, while exhibiting increased binding compared to wild-type magnetosomes.

Nanodiamond–Manganese dual mode MRI contrast agents for enhanced liver tumor detection

2017 ◽  
Vol 13 (3) ◽  
pp. 783-793 ◽  
Author(s):  
Weixin Hou ◽  
Tan Boon Toh ◽  
Lissa Nurrul Abdullah ◽  
Tay Wei Zheng Yvonne ◽  
Kuan J. Lee ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Liver Tumor ◽  
Tumor Detection ◽  
Mri Contrast Agents ◽  
Dual Mode ◽  
Mri Contrast

scholarly journals Fe/Mn Multilayer Nanowires as High-Performance T1-T2 Dual Modal MRI Contrast Agents

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2238
Author(s):  
Xiaoming Cao ◽  
Liyuan Gu ◽  
Shike Hu ◽  
Aiman Mukhtar ◽  
Kaiming Wu
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Performance ◽  
Mri Contrast Agents ◽  
Dual Mode ◽  
Mri Contrast ◽  
Mr Contrast Agents ◽  
Multilayer Nanowires ◽  
Near Future

A lot of nanomaterials are using T1-T2 dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T1-T2 dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T1-T2 dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r1 value (21.8 mM−1s−1) and r2 value (74.8 mM−1s−1) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM−1s−1) and Fe NW (59.3 mM−1s−1), respectively. We predict that our Fe/Mn multilayer NW could be used as T1-T2 dual mode MRI CAs in the near future.

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