Design, synthesis, and characterization of oxadiazolopyrazine analogs with application as anticancer agents

2021 ◽  
Author(s):  
Wei‐Chia Chen ◽  
Chia‐Ling Chen ◽  
Tzu‐Ting Chang ◽  
Feng‐Chun Hsieh ◽  
Wei‐Sheng Chen ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Synthesis And Characterization ◽  
Design Synthesis

scholarly journals Design, synthesis and characterization of novel chromone based-copper(ii) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37375-37390 ◽  
Author(s):  
Farukh Arjmand ◽  
Zeenat Afsan ◽  
Thierry Roisnel
Keyword(s):  
Anticancer Agents ◽  
Rna Binding ◽  
Antitumor Agents ◽  
Donor Ligands ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Binding Profile

New chromone-based Cu(ii) tRNA targeted complexes 1–3 as potential anticancer agents have been synthesized and thoroughly characterized.

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

2012 ◽  
Vol 22 (6) ◽  
pp. 2204-2208 ◽  
Author(s):  
Aldo Bianchi ◽  
Marcello Ugazzi ◽  
Luca Ferrante ◽  
Daniele Lecis ◽  
Cinzia Scavullo ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Rational Design ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Smac Mimetics ◽  
Potent Drug

scholarly journals Design of an n-type low glass transition temperature radical polymer

2021 ◽  
Author(s):  
Teng Chi ◽  
Siddhartha Akkiraju ◽  
Zihao Liang ◽  
Ying Tan ◽  
Ho Joong Kim ◽  
...  
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Synthesis And Characterization ◽  
Design Synthesis

We document the design, synthesis, and characterization of the first low glass transition temperature, n-type (i.e., preferentially-reduced) radical polymer.

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines

ChemMedChem ◽  
2020 ◽  
Vol 15 (13) ◽  
pp. 1150-1162
Author(s):  
Yu Lin ◽  
Zhanhui Li ◽  
Haikuo Ma ◽  
Yujie Wang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Cyclic Amines ◽  
Cxcr4 Antagonists

HYDRAmers: design, synthesis and characterization of different generation novel Hydra-like dendrons based on multifunctionalized adamantane

2011 ◽  
Vol 47 (31) ◽  
pp. 8955 ◽  
Author(s):  
Giuseppe Lamanna ◽  
Julie Russier ◽  
Cécilia Ménard-Moyon ◽  
Alberto Bianco
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis

scholarly journals Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain

2013 ◽  
Vol 65 ◽  
pp. 60-69 ◽  
Author(s):  
Sashikanth Banappagari ◽  
Alecia McCall ◽  
Krystal Fontenot ◽  
M. Graca H. Vicente ◽  
Amit Gujar ◽  
...  
Keyword(s):  
Extracellular Domain ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Her2 Protein

Design, synthesis, and characterization of one–dimensional ZnO/polymer nanohybrids

2013 ◽  
Vol 107 ◽  
pp. 162-165 ◽  
Author(s):  
Xianming Hou ◽  
Lixia Wang ◽  
Jingcheng Hao
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis ◽  
One Dimensional

DESIGN, SYNTHESIS, AND CHARACTERIZATION OF THE SOME NOVEL 2‐AMINO-PYRIDINE‐3‐ CARBONITRILE AND 2‐AMINO-4H-PYRAN‐3‐CARBONITRILE DERIVATIVES AGAINST ANTIMICROBIAL ACTIVITY AND ANTIOXIDANT ACTIVITY

2020 ◽  
pp. 125-134
Author(s):  
SURENDRA BABU LAGU ◽  
RAJENDRA PRASAD YEJELLA
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Antimicrobial Activities ◽  
Docking Studies ◽  
Synthesis And Characterization ◽  
Zone Of Inhibition ◽  
Design Synthesis ◽  
Instrumental Methods ◽  
Objective Investigation

Objective: Investigation, the series of newer 2‐amino-pyridine‐3‐carbonitrile and 2‐amino-4H-pyran‐3‐carbonitrile derivative were synthesized and evaluated antimicrobial activities and antioxidant activity. Methods: Novel synthesized chalcones were further condensation to give 2-amino-3-cyanopyridine and 2-amino-3-cyanopyrans in the presence of malononitrile, pyridine, and ammonia acetate. The product is characterized by conventional and instrumental methods. Pyridine and 4-H-Pyran and their analogs occupy prime position due to their diverse applications. Results: The compounds A3C and B3C exhibited marked zone of inhibition with 30.02±0.02 mm and 29.06±0.01 mm, respectively. Docking studies suggested possible interactions with dihydrofolic reductase 4 with 9.15 and −9.67 kcal/mol, respectively. The IC50 30.28±0.01 exhibited A3C by 2,2-diphenylpicrylhydrazyl methods which is better among the series. The 2-amino-3-cyanopyridine derivatives were found good activity than 2-amino-3-cyanopyrane derivative. Among all synthesized compounds few having potent activity and some are near to the standard. Conclusion: Antimicrobial activity and antioxidant of the newly synthesized pyrans and pyridines derivatives will definitely inspire future researchers for the preparation of new analogs.

Sign in / Sign up

Export Citation Format

Share Document