A reversed-phase/hydrophilic bifunctional interaction mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases for capillary electrochromatography

The Analyst ◽  
2019 ◽  
Vol 144 (14) ◽  
pp. 4386-4394 ◽  
Author(s):  
Zhenkun Mao ◽  
Changjun Hu ◽  
Zhentao Li ◽  
Zilin Chen
Keyword(s):  
Quaternary Ammonium ◽  
Capillary Electrochromatography ◽  
Mixed Mode ◽  
Monolithic Column ◽  
Stationary Phases ◽  
Reversed Phase

A novel RPLC/HILIC mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases is synthesized for capillary electrochromatography.

Reversed-phase and weak anion-exchange mixed-mode silica-based monolithic column for capillary electrochromatography

2006 ◽  
Vol 27 (17) ◽  
pp. 3363-3372 ◽  
Author(s):  
Guosheng Ding ◽  
Zhenliang Da ◽  
Ruijuan Yuan ◽  
James J. Bao
Keyword(s):  
Anion Exchange ◽  
Capillary Electrochromatography ◽  
Mixed Mode ◽  
Monolithic Column ◽  
Reversed Phase

Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography

2015 ◽  
Vol 7 (11) ◽  
pp. 4750-4756 ◽  
Author(s):  
Sheng Tang ◽  
Yong Guo ◽  
Xiaojing Liang ◽  
Falin Wei ◽  
Limin Yang ◽  
...  
Keyword(s):  
Capillary Electrochromatography ◽  
Mixed Mode ◽  
Monolithic Column ◽  
Reversed Phase

A novel mixed-mode monolithic column was prepared and applied for reversed-phase and per aqueous capillary electrochromatography.

An innovative reversed-phase monolithic column modified with 4-vinylbiphenyl and ionic liquid stationary phases for capillary electrochromatography

2019 ◽  
Vol 43 (30) ◽  
pp. 12013-12019 ◽  
Author(s):  
Xiangju Mao ◽  
Lu Liu ◽  
Fang Xiao ◽  
Wenshan Ni ◽  
Xintao Cheng
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrochromatography ◽  
Monolithic Column ◽  
Stationary Phases ◽  
Reversed Phase ◽  
Electrochromatographic Separation

A poly(VBP-co-EDMA-co-IL) monolithic column was used for electrochromatographic separation.

scholarly journals Reversed-Phase HPLC Analysis of Levetiracetam in Tablets Using Monolithic and Conventional C18 Silica Columns

2010 ◽  
Vol 93 (4) ◽  
pp. 1077-1085 ◽  
Author(s):  
Nafiz O Can ◽  
Goksel Arli
Keyword(s):  
Monolithic Column ◽  
Stationary Phases ◽  
Internal Standard ◽  
Reversed Phase ◽  
Hplc Method ◽  
Array Detector ◽  
Pharmaceutical Tablets ◽  
System Suitability ◽  
Development And Validation

Abstract Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed using a single analytical procedure with two different types of stationary phases, conventional Phenomenex Gemini C18 (100 4.6 mm, 5 m) and Merck Chromolith Performance RP18e (100 4.6 mm, macropore size 2 mm, micropore size 13 nm) monolithic silica. Five-microliter aliquots of samples were injected into the system and eluted using wateracetonitrile (90 + 10, v/v) mobile phase pumped at the rate of 1 mL/min. The analyte peaks were detected at 200 nm using a diode array detector with adequate resolution. Validation studies were performed using the method recommended by the International Conference on Harmonization, the U.S. Pharmacopeia, and AOAC INTERNATIONAL, which includes accuracy, precision, range, limits, robustness, and system suitability parameters. Levetiracetam and caffeine were detected in about 7 min using the conventional column, whereas less than 5 min was required when the monolithic column was used. Calibration plots had r values close to unity in the range of 0.88.0 g/mL. Assay of levetiracetam in a tablet formulation was demonstrated as an application to real samples.

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