An innovative reversed-phase monolithic column modified with 4-vinylbiphenyl and ionic liquid stationary phases for capillary electrochromatography

2019 ◽  
Vol 43 (30) ◽  
pp. 12013-12019 ◽  
Author(s):  
Xiangju Mao ◽  
Lu Liu ◽  
Fang Xiao ◽  
Wenshan Ni ◽  
Xintao Cheng
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrochromatography ◽  
Monolithic Column ◽  
Stationary Phases ◽  
Reversed Phase ◽  
Electrochromatographic Separation

A poly(VBP-co-EDMA-co-IL) monolithic column was used for electrochromatographic separation.

A reversed-phase/hydrophilic bifunctional interaction mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases for capillary electrochromatography

The Analyst ◽  
2019 ◽  
Vol 144 (14) ◽  
pp. 4386-4394 ◽  
Author(s):  
Zhenkun Mao ◽  
Changjun Hu ◽  
Zhentao Li ◽  
Zilin Chen
Keyword(s):  
Quaternary Ammonium ◽  
Capillary Electrochromatography ◽  
Mixed Mode ◽  
Monolithic Column ◽  
Stationary Phases ◽  
Reversed Phase

A novel RPLC/HILIC mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases is synthesized for capillary electrochromatography.

Ionic-Liquid-Modified, Hybrid Silica Monolithic Column for Capillary Electrochromatography

2011 ◽  
Vol 39 (6) ◽  
pp. 827-832 ◽  
Author(s):  
Rui FENG ◽  
Min SHEN ◽  
Ming-Ming WANG ◽  
Hao CHEN ◽  
Zhao-Rui ZENG
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrochromatography ◽  
Monolithic Column ◽  
Hybrid Silica

Application of Mobile Phases Containing Ionic Liquid for HPLC Analysis of Selected Isoquinoline Alkaloids

2017 ◽  
Vol 100 (6) ◽  
pp. 1652-1659 ◽  
Author(s):  
Anna Petruczynik ◽  
Justyna Misiurek ◽  
Tomasz Tuzimski ◽  
Monika Waksmundzka-Hajnos
Keyword(s):  
Ionic Liquid ◽  
Stationary Phases ◽  
Reversed Phase ◽  
System Efficiency ◽  
Organic Modifier ◽  
Optimal Conditions ◽  
Retention Behavior ◽  
Isoquinoline Alkaloids ◽  
Mobile Phases ◽  
Chemical Groups

Abstract An HPLC procedure on a polar reversed-phase column with mobile phases containing ionic liquid (IL) was developed for the analysis of selected alkaloids from different chemical groups. We aimed to obtain optimal conditions for the separation of alkaloids because widely used silica-based stationary phases exhibit a silanol effect, rendering analysis of basic analytes extremely difficult. Retention, separation selectivity, peak symmetry, and system efficiency were examined in various eluent systems containing different concentrations of IL and acetonitrile. The obtained results revealed substantial influence from the concentrations of IL, the organic modifier, and temperature on the retention behavior of the investigated alkaloids. The most selective and efficient chromatographic systems were applied for the analysis of several alkaloids in a plant extract.

scholarly journals Reversed-Phase HPLC Analysis of Levetiracetam in Tablets Using Monolithic and Conventional C18 Silica Columns

2010 ◽  
Vol 93 (4) ◽  
pp. 1077-1085 ◽  
Author(s):  
Nafiz O Can ◽  
Goksel Arli
Keyword(s):  
Monolithic Column ◽  
Stationary Phases ◽  
Internal Standard ◽  
Reversed Phase ◽  
Hplc Method ◽  
Array Detector ◽  
Pharmaceutical Tablets ◽  
System Suitability ◽  
Development And Validation

Abstract Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed using a single analytical procedure with two different types of stationary phases, conventional Phenomenex Gemini C18 (100 4.6 mm, 5 m) and Merck Chromolith Performance RP18e (100 4.6 mm, macropore size 2 mm, micropore size 13 nm) monolithic silica. Five-microliter aliquots of samples were injected into the system and eluted using wateracetonitrile (90 + 10, v/v) mobile phase pumped at the rate of 1 mL/min. The analyte peaks were detected at 200 nm using a diode array detector with adequate resolution. Validation studies were performed using the method recommended by the International Conference on Harmonization, the U.S. Pharmacopeia, and AOAC INTERNATIONAL, which includes accuracy, precision, range, limits, robustness, and system suitability parameters. Levetiracetam and caffeine were detected in about 7 min using the conventional column, whereas less than 5 min was required when the monolithic column was used. Calibration plots had r values close to unity in the range of 0.88.0 g/mL. Assay of levetiracetam in a tablet formulation was demonstrated as an application to real samples.

A novel C18 reversed phase organic–silica hybrid cationic monolithic capillary column with an ionic liquid as an organic monomer via a “one-pot” approach for capillary electrochromatography

RSC Advances ◽  
2014 ◽  
Vol 4 (30) ◽  
pp. 15518-15525 ◽  
Author(s):  
Guozhen Fang ◽  
Hailong Qian ◽  
Qiliang Deng ◽  
Xuqin Ran ◽  
Yukun Yang ◽  
...  
Keyword(s):  
Capillary Electrochromatography ◽  
Capillary Column ◽  
Monolithic Column ◽  
Reversed Phase ◽  
One Pot ◽  
Organic Silica ◽  
Hybrid Monolithic Column ◽  
Monolithic Capillary Column ◽  
Silica Hybrid ◽  
Organic Monomer

A novel IL hybrid monolithic column with great potential in separation has been fabricated via a “one-pot” approach for capillary electrochromatography

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