Highly regioselective ring-opening of epoxides with amines: a metal- and solvent-free protocol for the synthesis of β-amino alcohols

2020 ◽  
Vol 56 (15) ◽  
pp. 2256-2259
Author(s):  
Dong Li ◽  
Jing Wang ◽  
Shibo Yu ◽  
Silei Ye ◽  
Wenjie Zou ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ring Opening ◽  
Amino Alcohols ◽  
Solvent Free ◽  
Ring Opening Reaction ◽  
Ring Opening Of Epoxides

We herein report a metal- and solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines.

Synthesis of β-amino alcohols using MgO as a new catalyst under solvent-free conditions

2008 ◽  
Vol 86 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Mona Hosseini-Sarvari
Keyword(s):  
Ring Opening ◽  
Amino Alcohols ◽  
Solvent Free ◽  
Aliphatic Amines ◽  
Solvent Free Conditions ◽  
Ring Opening Of Epoxides ◽  
High Yields ◽  
Aromatic And Aliphatic Amines

MgO catalyzed efficiently the ring opening of epoxides with a range of aromatic and aliphatic amines to produce β-substituted alcohols in high yields under solvent-free conditions. Exclusive trans stereoselectivity is observed for cyclic epoxide.Key words: MgO, β-amino alcohols, solvent-free, epoxide, amine.

A solvent free method for preparation of β-amino alcohols by ring opening of epoxides with amines using MCM-22 as a catalyst

2016 ◽  
Vol 524 ◽  
pp. 50-55 ◽  
Author(s):  
Thangaraj Baskaran ◽  
Akanksha Joshi ◽  
Gunda Kamalakar ◽  
Ayyamperumal Sakthivel
Keyword(s):  
Ring Opening ◽  
Amino Alcohols ◽  
Solvent Free ◽  
Ring Opening Of Epoxides

An efficient method for regioselective ring opening of epoxides by amines under microwave irradiation using Bi(NO3)3·5H2O as a catalyst

2017 ◽  
Vol 41 (7) ◽  
pp. 2668-2671 ◽  
Author(s):  
Shobha Bansal ◽  
Yogendra Kumar ◽  
Parveen Pippal ◽  
Dipak K. Das ◽  
Panchanan Pramanik ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Ring Opening ◽  
Amino Alcohols ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Highly Efficient ◽  
Ring Opening Of Epoxides ◽  
Nucleophilic Ring Opening

Bi(NO3)3·5H2O a highly efficient environmentally benign catalyst, is used for the nucleophilic ring opening of epoxides with aromatic, aliphatic and heteroaromatic amines under solvent free microwave conditions to afford the corresponding β-amino alcohols in good to excellent yields with high regioselectivity.

scholarly journals Regioselective Ring Opening of Epoxides with Amines Using Silica-bonded S-sulfonic Acid under Solvent-free Conditions

2017 ◽  
Vol 56 (4) ◽  
Author(s):  
Mahmood Tajbakhsh ◽  
Rahman Hosseinzadeh ◽  
Parizad Rezaee ◽  
Heshmatollah Alinezhad
Keyword(s):  
Ring Opening ◽  
Sulfonic Acid ◽  
Room Temperature ◽  
Amino Alcohols ◽  
Solvent Free ◽  
High Yield ◽  
Reusable Catalyst ◽  
Solvent Free Conditions ◽  
Ring Opening Of Epoxides

Silica-bonded S-sulfonic acid (SBSSA) was used as a recyclable and reusable catalyst for the synthesis of β-amino alcohols. Several amines were reacted with epoxides to afford regioselective β-amino alcohols in high yield under solvent-free conditions at room temperature.

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