Peroxide-mediated site-specific C–H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free conditions

2020 ◽  
Vol 18 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Shengzhou Jin ◽  
Hua Yao ◽  
Sen Lin ◽  
Xiaoqing You ◽  
Yao Yang ◽  
...  
Keyword(s):  
Site Specific ◽  
Metal Free

An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is described.

A Synthetic Method for Site‐Specific Functionalized Polypeptides: Metal‐Free, Highly Active, and Selective at Room Temperature

2020 ◽  
Vol 60 (2) ◽  
pp. 889-895
Author(s):  
Wei Zhao ◽  
Yanfeng Lv ◽  
Ji Li ◽  
Zihao Feng ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Room Temperature ◽  
Synthetic Method ◽  
Site Specific ◽  
Metal Free ◽  
Highly Active

A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms

2020 ◽  
Vol 22 (3) ◽  
pp. 669-672 ◽  
Author(s):  
Shuai Shi ◽  
Ruining Li ◽  
Liangming Rao ◽  
Zhankui Sun
Keyword(s):  
Visible Light ◽  
Functional Group ◽  
Site Specific ◽  
Metal Free ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Radical Approach

Visible light induced desulfurization–deuteration method was developed using D2O as the source of deuterium atoms. This radical approach features mild conditions, broad substrate scope, highly efficient D-incorporation and excellent functional group compatibility.

scholarly journals A Synthetic Method for Site‐Specific Functionalized Polypeptides: Metal‐Free, Highly Active, and Selective at Room Temperature

2020 ◽  
Vol 133 (2) ◽  
pp. 902-908
Author(s):  
Wei Zhao ◽  
Yanfeng Lv ◽  
Ji Li ◽  
Zihao Feng ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Room Temperature ◽  
Synthetic Method ◽  
Site Specific ◽  
Metal Free ◽  
Highly Active

Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition

2018 ◽  
Vol 16 (11) ◽  
pp. 1823-1827 ◽  
Author(s):  
Rongzhen Chen ◽  
Jin-Tao Yu ◽  
Jiang Cheng
Keyword(s):  
Conjugate Addition ◽  
Site Specific ◽  
Metal Free ◽  
Type Radical

The metal-free C2-functionalization of chromones with alcohols and ethers via radical sp3 C–H activation was developed.

Metal-Free Site-Specific Hydroxyalkylation of Imidazo[1,2-a]pyridines with Alcohols through Radical Reaction

2019 ◽  
Vol 21 (9) ◽  
pp. 3436-3440 ◽  
Author(s):  
Shengzhou Jin ◽  
Bo Xie ◽  
Sen Lin ◽  
Cong Min ◽  
Ruihong Deng ◽  
...  
Keyword(s):  
Radical Reaction ◽  
Site Specific ◽  
Metal Free

Site-Specific Cleavage of RNA by a Metal-Free Artificial Nuclease Attached to Antisense Oligonucleotides

2006 ◽  
Vol 128 (24) ◽  
pp. 8063-8067 ◽  
Author(s):  
Claudio Gnaccarini ◽  
Sascha Peter ◽  
Ute Scheffer ◽  
Stefan Vonhoff ◽  
Sven Klussmann ◽  
...  
Keyword(s):  
Antisense Oligonucleotides ◽  
Site Specific ◽  
Metal Free ◽  
Artificial Nuclease

The Shadow Widths of Very Small Particles are Formed Independently of the Metal Cap Build Up on the Particle

1981 ◽  
Vol 39 ◽  
pp. 568-569
Author(s):  
George C. Ruben
Keyword(s):  
Gold Particle ◽  
Film Surface ◽  
Small Particles ◽  
Geometric Process ◽  
Metal Free ◽  
Shadow Area

The formation of shadows behind small particles has been thought to be a geometric process (GP) where the metal cap build up on the particle creates a shadow width the same size as or larger than the particle. This GP cannot explain why gold particle shadow widths are generally larger than the gold particle and may have no appreciable metal cap build up (fig. 1). Ruben and Telford have suggested that particle shadow widths are formed by the width dependent deflection of shadow metal (SM) lateral to and infront of the particle. The trajectory of the deflected SM is determined by the incoming shadow angle (45°). Since there can be up to 1.4 times (at 45°) more SM directly striking the particle than the film surface, a ridge of metal nuclei lateral to and infront of the particle can be formed. This ridge in turn can prevent some SM from directly landing in the metal free shadow area. However, the SM that does land in the shadow area (not blocked by the particle or its ridge) does not stick and apparently surface migrates into the SM film behind the particle.

Large-cluster and combined fluorescent and gold immunoprobes

1996 ◽  
Vol 54 ◽  
pp. 892-893
Author(s):  
Richard D. Powell ◽  
James F. Hainfeld ◽  
Carol M. R. Halsey ◽  
David L. Spector ◽  
Shelley Kaurin ◽  
...  
Keyword(s):  
Metal Cluster ◽  
Sulfonyl Chloride ◽  
Gel Filtration ◽  
Cross Linking ◽  
Site Specific ◽  
Fab Fragments ◽  
Cluster Label ◽  
Covalently Linked ◽  
Texas Red ◽  
Fold Excess

Two new types of covalently linked, site-specific immunoprobes have been prepared using metal cluster labels, and used to stain components of cells. Combined fluorescein and 1.4 nm “Nanogold” labels were prepared by using the fluorescein-conjugated tris (aryl) phosphine ligand and the amino-substituted ligand in the synthesis of the Nanogold cluster. This cluster label was activated by reaction with a 60-fold excess of (sulfo-Succinimidyl-4-N-maleiniido-cyclohexane-l-carboxylate (sulfo-SMCC) at pH 7.5, separated from excess cross-linking reagent by gel filtration, and mixed in ten-fold excess with Goat Fab’ fragments against mouse IgG (obtained by reduction of F(ab’)2 fragments with 50 mM mercaptoethylamine hydrochloride). Labeled Fab’ fragments were isolated by gel filtration HPLC (Superose-12, Pharmacia). A combined Nanogold and Texas Red label was also prepared, using a Nanogold cluster derivatized with both and its protected analog: the cluster was reacted with an eight-fold excess of Texas Red sulfonyl chloride at pH 9.0, separated from excess Texas Red by gel filtration, then deprotected with HC1 in methanol to yield the amino-substituted label.

Recent advancement in the electrocatalytic synthesis of ammonia

Nanoscale ◽  
2020 ◽  
Vol 12 (15) ◽  
pp. 8065-8094 ◽  
Author(s):  
Xudong Wen ◽  
Jingqi Guan
Keyword(s):  
Metal Oxide ◽  
Oxide Catalysts ◽  
Single Atom ◽  
Metal Oxide Catalysts ◽  
Metal Free ◽  
Recent Advancement ◽  
Nanocomposite Catalysts

Different kinds of electrocatalysts used in NRR electrocatalysis (including single atom catalysts, metal oxide catalysts, nanocomposite catalysts, and metal free catalysts) are introduced.

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