Sustainable Entrepreneurship and Innovation. Addressing the Grand Challenges through Radical Change and Open Innovation.

Sustainable Entrepreneurship and Innovation are essential tools in the transition towards a more fair, healthy, and sustainable society. This chapter gives an overview of the two decades of research on the topic and discusses the current state of its application. It shows that the current literature lacks a more profound theoretical and practical investigation. Nevertheless, these gaps may be covered soon, as the number of publications in this area is growing. Additionally, the chapter explores the importance of a radical approach, open innovation strategies, and collaboration to foster sustainable entrepreneurship and innovation and tackle the Grand Challenges of modern society.

A farewell to the lone hero researcher: team research and writing

Criminology have long celebrated the lone hero researcher. Doing and writing up research in solitude has been the key to academic success and institutional promotions. However, the social sciences in general have increasingly moved towards more collaborative ways of doing research, and co-authorship has become more common. In this study, we summarize and discuss the pros and cons of working in teams when doing qualitative research. Drawing upon our own experiences from Mexico and Norway, we argue for a radical approach to team research and co-authorship, which we describe as team writing. Most importantly, we suggest opening up to include stakeholders and community partners, thus challenging the borders between researchers and those researched. This is arguably particularly important for research done in the academic, geographical and topical periphery of criminology. Team research and writing answers some of the critique of power inequality, representativity and lack of diversity in contemporary academic research. We also believe that team research, and writing, can make criminological research more multifaceted, reflexive, and thus better.

Cascade Approaches Towards the Synthesis of Daphnioldhanin A Alkaloid

<p>Daphnioldhanin A 1.6 is a recent alkaloid obtained from Daphyniphyllum plants. The core structure as shown consists of a 5,5,7 tricyclic ring system, which is a challenging ring system and to date has not been reported in any other natural product. This project focussed on using two cascade approaches in forming this ring system, namely radical addition and cyclisation cascade and carbene cycloaddition cyclisation cascade CCCC. Using the radical approach would require a 5-endo trig cyclisation, which is disfavoured by Baldwin's rules, but has been reported in systems which have an hetereoatom (carbonyl, nitrogen or sulfur) incorporated in the ring. In our case, the 5-endo trig cyclisation is needed in an all carbon containing ring, and preliminary modelling studies have shown that the energy for the 4-exo trig cyclisation product is higher than that of the 5-endo trig cyclisation product. Therefore, the radical approach if successful will eventuate in a novel 5-endo trig cyclisation in an all carbon system. However, due to stability issues with the radical precursors this method had to be abandoned and attention focused on the CCCC approach. For the CCCC approach, rhodium catalysed cascade cyclisation is intended on diazo compound 1.22. The presence of the intramolecular double bond enhances the second cyclisation to occur which will form the 5 and 7-membered ring simultaneously along with oxo-bridge resulting in the functionalised pentacyclic ring system which would be very similar to the proposed 5,5,7 core of Daphnioldhanin A. The desired diazo compound could not synthesised due to failure in forming the anhydride for the acid and future work would be focussed on forming acid derivatives in order to form the diazo compound 1.22 before using rhodium catalysed cyclisation to form the functionalised pentacyclic compound.</p>

Cascade Approaches Towards the Synthesis of Daphnioldhanin A Alkaloid

<p>Daphnioldhanin A 1.6 is a recent alkaloid obtained from Daphyniphyllum plants. The core structure as shown consists of a 5,5,7 tricyclic ring system, which is a challenging ring system and to date has not been reported in any other natural product. This project focussed on using two cascade approaches in forming this ring system, namely radical addition and cyclisation cascade and carbene cycloaddition cyclisation cascade CCCC. Using the radical approach would require a 5-endo trig cyclisation, which is disfavoured by Baldwin's rules, but has been reported in systems which have an hetereoatom (carbonyl, nitrogen or sulfur) incorporated in the ring. In our case, the 5-endo trig cyclisation is needed in an all carbon containing ring, and preliminary modelling studies have shown that the energy for the 4-exo trig cyclisation product is higher than that of the 5-endo trig cyclisation product. Therefore, the radical approach if successful will eventuate in a novel 5-endo trig cyclisation in an all carbon system. However, due to stability issues with the radical precursors this method had to be abandoned and attention focused on the CCCC approach. For the CCCC approach, rhodium catalysed cascade cyclisation is intended on diazo compound 1.22. The presence of the intramolecular double bond enhances the second cyclisation to occur which will form the 5 and 7-membered ring simultaneously along with oxo-bridge resulting in the functionalised pentacyclic ring system which would be very similar to the proposed 5,5,7 core of Daphnioldhanin A. The desired diazo compound could not synthesised due to failure in forming the anhydride for the acid and future work would be focussed on forming acid derivatives in order to form the diazo compound 1.22 before using rhodium catalysed cyclisation to form the functionalised pentacyclic compound.</p>

Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-10B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug

Boron neutron capture therapy (BNCT) is a powerful and selective anti-cancer therapy utilizing 10B-enriched boron drugs. However, clinical advancement of BCNT is hampered by the insufficient loading of B-10 drugs throughout the solid tumor. Furthermore, the preparation of boron drugs for BNCT relies on the use of the costly B-10 enriched precursor. To overcome these challenges, polymer-coated boron carbon oxynitride (BCNO) nanoparticles, with ~30% of boron, were developed with enhanced biocompatibility, cell uptake, and tumoricidal effect via BNCT. Using the ALTS1C1 cancer cell line, the IC50 of the PEG@BCNO, bare, PEI@BCNO were determined to be 0.3 mg/mL, 0.1 mg/mL, and 0.05 mg/mL, respectively. As a proof-of-concept, the engineered non-10B enriched polymer-coated BCNO exhibited excellent anti-tumor effect via BNCT due to their high boron content per nanoparticle and due to the enhanced cellular internalization and retention compared to small molecular 10B-BPA drug. The astrocytoma ALTS1C1 cells treated with bare, polyethyleneimine-, and polyethylene glycol-coated BCNO exhibited an acute cell death of 24, 37, and 43%, respectively, upon 30 min of neutron irradiation compared to the negligible cell death in PBS-treated and non-irradiated cells. The radical approach proposed in this study addresses the expensive and complex issues of B-10 isotope enrichment process; thus, enabling the preparation of boron drugs at a significantly lower cost, which will facilitate the development of boron drugs for BNCT.

Glimmers of hope: a global Green New Deal is feasible

In light of limited international climate policy efforts, many are pessimistic about effective climate change mitigation. However, there is still a chance for a global Green New Deal which would reduce both socio-economic inequalities and greenhouse gas emissions. Unfolding feedbacks between technological, behavioral, and political changes provide an opportunity for transforming our societies. Yet, a Green New Deal in line with the green growth paradigm seems politically more feasible than a radical approach that rests upon a de-growth paradigm.

Diana, the Challenger: A Feminist Figure of Power and Salvation in Hollywood Feminist Fantasy Wonder Woman (2017)

Jenkins (2017) Wonder Woman is a portrayal of the traditional role of feminism, in which masculine traits including courage, strength, leadership, independence, and assertiveness are used to overwhelm male-dominant society, while manhood as a masculine trait is challenged by a woman constantly striving for power and authority. Marriage is shown as a failed philosophy in the movie, while men are shown just a minimal need to procreate. ‘Wonder Woman’ has an extensive gay male and lesbian fan base. This task approaches Wonder Woman with a semiotic and cultural examination to perceive how her character is comprised of some syntagmas that empower this sort of identification like same-sex society, battling bigotry, discovering one's place, and flourishing in transformation. The analysis shows that the virtue of fighting for peace in Diana has been compromised with the amalgamation of feminists’ radical approach. She has been presented as a female rebellion, while the rightful cause of the caretaker feminists has been degenerated by the amalgamating of bad feminism with good feminism. Keywords: masculine traits, male-dominant society, feminism, syntagmas, same-sex society, female rebellion