scholarly journals Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions

2019 ◽  
Vol 10 (45) ◽  
pp. 10481-10492 ◽  
Author(s):  
Marco Potowski ◽  
Florian Losch ◽  
Elena Wünnemann ◽  
Janina K. Dahmen ◽  
Silvia Chines ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Dna Sequences ◽  
Solid Phase ◽  
Alder Reaction ◽  
Solid Support ◽  
Diels Alder ◽  
Dna Oligonucleotides ◽  
Compound Libraries ◽  
Diels Alder Reaction ◽  
Selection Of

DNA-encoded compound libraries are widely used in drug discovery. Screening of catalysts for compatibility with solid phase-coupled DNA sequences guided the selection of encoded reactions, exemplified by a Zn(II)-mediated aza-Diels–Alder reaction.

Solid-Phase Organic Synthesis of Dexoxadrol Analogues

2013 ◽  
Vol 66 (1) ◽  
pp. 93 ◽  
Author(s):  
Michael Sax ◽  
Bernhard Wünsch
Keyword(s):  
Solid Phase ◽  
Alder Reaction ◽  
Solid Support ◽  
Diels Alder ◽  
Piperidine Ring ◽  
Phase Synthesis ◽  
Diels Alder Reaction ◽  
Conjugate Reduction ◽  
Solid Phase Organic Synthesis ◽  
Danishefsky's Diene

A solid-phase synthesis of dexoxadrol analogues like-13 and unlike-13 bearing an oxo group in the 4-position of the piperidine ring has been developed using aminomethyl substituted polystyrene resin as solid support. The synthesis comprises a hetero-Diels–Alder reaction of imine 7b with Danishefsky’s diene 8 in the presence of the Lewis acid Yb(OTf)3 and a conjugate reduction of the double bond of 9b with LiBHEt3 and BF3. The cleavage of the product from the solid support was performed with 1-chloroethyl chloroformate. All transformations on the solid support and additionally the cleavage reaction had to be compatible with the large and acid labile acetalic 1,3-dioxolane moiety in 2-position of the piperidine ring. The oxodexoxadrol derivative 12 was obtained in an overall yield of 17 %.

Stereoselective Aza Diels−Alder Reaction on Solid Phase:  A Facile Synthesis of Hexahydrocinnoline Derivatives

2007 ◽  
Vol 9 (2) ◽  
pp. 263-266 ◽  
Author(s):  
Alexandros Kiriazis ◽  
Tobias Rüffer ◽  
Sirkku Jäntti ◽  
Heinrich Lang ◽  
Jari Yli-Kauhaluoma
Keyword(s):  
Solid Phase ◽  
Alder Reaction ◽  
Diels Alder ◽  
Facile Synthesis ◽  
Diels Alder Reaction

Thermally reliable, recyclable and malleable solid–solid phase-change materials through the classical Diels–Alder reaction for sustainable thermal energy storage

2019 ◽  
Vol 7 (38) ◽  
pp. 21802-21811 ◽  
Author(s):  
Bo Wu ◽  
Yi Wang ◽  
Zhimeng Liu ◽  
Yuan Liu ◽  
Xiaowei Fu ◽  
...  
Keyword(s):  
Renewable Energy ◽  
Energy Storage ◽  
Phase Change Materials ◽  
Solid Phase ◽  
Alder Reaction ◽  
Diels Alder ◽  
Energy Capture ◽  
Diels Alder Reaction ◽  
Renewable Energy Storage ◽  
Capture Capacity

DC-PCMs are facilely fabricated for renewable energy storage, and can be fully recycled and reshaped without sacrificing the energy-capture capacity.

scholarly journals Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

2018 ◽  
Vol 14 ◽  
pp. 318-324 ◽  
Author(s):  
Imane Nekkaa ◽  
Márta Palkó ◽  
István M Mándity ◽  
Ferenc Fülöp
Keyword(s):  
Efficient Method ◽  
Continuous Flow ◽  
Reaction Times ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Selection Of

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels–Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.

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