Organic small molecule for detection and photodegradation of mitochondrial DNA mutations

2019 ◽  
Vol 7 (39) ◽  
pp. 5947-5955
Author(s):  
Chien-Hui Su ◽  
Jyun-Wei Chen ◽  
Li-Da Chen ◽  
Jui-Chih Chang ◽  
Chin-San Liu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Dna ◽  
Small Molecule ◽  
Reactive Oxygen ◽  
Methyl Blue ◽  
Oxygen Species ◽  
Mitochondrial Localization ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

Mitochondrial localization photosensitizer NV-12P may recognize 8-oxo-dG with PET and FRET mechanism. Furthermore, NV-12P can generate a reactive oxygen species to degrade 8-oxo-dG using a similar mechanism of methyl blue.

Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants

2006 ◽  
Vol 38 (11) ◽  
pp. 1261-1268 ◽  
Author(s):  
Raquel Moreno-Loshuertos ◽  
Rebeca Acín-Pérez ◽  
Patricio Fernández-Silva ◽  
Nieves Movilla ◽  
Acisclo Pérez-Martos ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Dna ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dna Variants ◽  
Species Production ◽  
Mitochondrial Dna Variants

The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species

2011 ◽  
Vol 43 (1) ◽  
pp. 25-29 ◽  
Author(s):  
R. A. P. Costa ◽  
C. D. Romagna ◽  
J. L. Pereira ◽  
N. C. Souza-Pinto
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Dna Damage

scholarly journals Mitochondria, oxidative stress and aging

2014 ◽  
Vol 155 (12) ◽  
pp. 447-452
Author(s):  
András Szarka ◽  
Gábor Bánhegyi ◽  
Balázs Sümegi
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Dna ◽  
Mitochondrial Respiration ◽  
Accelerated Aging ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Vicious Cycle ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Theory Of Aging

The free radical theory of aging was defined in the 1950s. On the base of this theory, the reactive oxygen species formed in the metabolic pathways can play pivotal role in ageing. The theory was modified by defining the mitochondrial respiration as the major cellular source of reactive oxygen species and got the new name mitochondrial theory of aging. Later on the existence of a “vicious cycle” was proposed, in which the reactive oxygen species formed in the mitochondrial respiration impair the mitochondrial DNA and its functions. The formation of reactive oxygen species are elevated due to mitochondrial dysfunction. The formation of mitochondrial DNA mutations can be accelerated by this “vicious cycle”, which can lead to accelerated aging. The exonuclease activity of DNA polymerase γ, the polymerase responsible for the replication of mitochondrial DNA was impaired in mtDNA mutator mouse recently. The rate of somatic mutations in mitochondrial DNA was elevated and an aging phenotype could have been observed in these mice. Surprisingly, no oxidative impairment neither elevated reactive oxygen species formation could have been observed in the mtDNA mutator mice, which may question the existence of the “vicious cycle”. Orv. Hetil., 2014, 155(12), 447–452.

Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes

2011 ◽  
Vol 27 (5) ◽  
pp. 470-479 ◽  
Author(s):  
Octavian Savu ◽  
Vivekananda Gupta Sunkari ◽  
Ileana Ruxandra Botusan ◽  
Jacob Grünler ◽  
Andrej Nikoshkov ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Dna ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death

2013 ◽  
Vol 8 (5) ◽  
pp. 923-929 ◽  
Author(s):  
Drew J. Adams ◽  
Zarko V. Boskovic ◽  
Jimmy R. Theriault ◽  
Alex J. Wang ◽  
Andrew M. Stern ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Small Molecule ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Small Molecule Enhancers
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