A Michael addition reaction-based fluorescent probe for malononitrile detection and its applications in aqueous solution, living cells and zebrafish

The Analyst ◽  
2021 ◽  
Vol 146 (7) ◽  
pp. 2221-2228
Author(s):  
Liangping Tu ◽  
Jian Liu ◽  
Zichang Zhang ◽  
Qingrong Qi ◽  
Shun Yao ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Fluorescent Probe ◽  
Michael Addition ◽  
Addition Reaction ◽  
Living Cells ◽  
Sensitive Detection ◽  
Michael Addition Reaction ◽  
Sensing Mechanism

A fluorescent probe Hcy-DCV with a new sensing mechanism for quick and sensitive detection of malononitrile was developed.

A simple but effective fluorescent probe for the detection of bisulfite

2017 ◽  
Vol 41 (10) ◽  
pp. 3986-3990 ◽  
Author(s):  
Jing Luo ◽  
Guangjie Song ◽  
Xujiao Xing ◽  
Shili Shen ◽  
Yanqing Ge ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction

A simple but effective fluoresecent probe for the detection of bisulfite based on Michael addition reaction.

scholarly journals A Flavone Fluorescent Probe for Cysteine Detection

2019 ◽  
Vol 31 (12) ◽  
pp. 2909-2914
Author(s):  
Saleh N. Al-Busafi ◽  
Salma M. Al-Kindi ◽  
Fakhr Eldin O. Suliman ◽  
Aliya A. Al-Kalbani
Keyword(s):  
Amino Acids ◽  
Fluorescent Probe ◽  
1H Nmr ◽  
Michael Addition ◽  
Addition Reaction ◽  
Fluorescence Emission ◽  
Selective Detection ◽  
Michael Addition Reaction ◽  
Uv Visible ◽  
The Michael Addition

A new blue-emitting fluorescent probe 1 based on flavone structure was prepared for the selective detection of cysteine. The probe was prepared through three synthetic steps from commercially available starting materials. Selective detection of cysteine by probe 1 in the presence of other non-thiol amino acids was established by UV-visible and fluorescent experiments. A remarkable fluorescence emission was observed at 469 nm when cysteine was mixed with probe 1. The Michael addition reaction of cysteine to probe-1 was confirmed by 1H NMR technique.

Biomimic modification of graphene oxide

2015 ◽  
Vol 39 (10) ◽  
pp. 8172-8178 ◽  
Author(s):  
Lihua Fu ◽  
Yingge Shi ◽  
Ke Wang ◽  
Ping Zhou ◽  
Meiying Liu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Graphene Oxide ◽  
Michael Addition ◽  
Addition Reaction ◽  
Synthetic Polymer ◽  
Michael Addition Reaction ◽  
Modified Graphene Oxide ◽  
Modified Graphene

Synthetic polymer modified graphene oxide was prepared via combination of mussel inspired chemistry and Michael addition reaction in aqueous solution.

Cupin Variants as Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes

2019 ◽  
Author(s):  
Nobutaka Fujieda ◽  
Miho Yuasa ◽  
Yosuke Nishikawa ◽  
Genji Kurisu ◽  
Shinobu Itoh ◽  
...  
Keyword(s):  
Michael Addition ◽  
In Silico ◽  
Addition Reaction ◽  
Single Point ◽  
Point Mutations ◽  
Unsaturated Ketone ◽  
Michael Addition Reaction ◽  
Beta Barrel ◽  
Cupin Superfamily ◽  
Single Point Mutations

Cupin superfamily proteins (TM1459) work as a macromolecular ligand framework with a double-stranded beta-barrel structure ligating to a Cu ion through histidine side chains. Variegating the first coordination sphere of TM1459 revealed that H52A and H54A/H58A mutants effectively catalyzed the diastereo- and enantio-selective Michael addition reaction of nitroalkanes to an α,β-unsaturated ketone. Moreover, in silico substrate docking signified C106N and F104W single-point mutations, which inverted the diastereoselectivity of H52A and further improved the stereoselectivity of H54A/H58A, respectively.

Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones

Synthesis ◽  
2021 ◽  
Author(s):  
Azim Ziyaei Halimehjani ◽  
Petr Beier ◽  
Maryam Khalili Foumeshi ◽  
Ali Alaei ◽  
Blanka Klepetářová
Keyword(s):  
Amino Acids ◽  
Carbon Disulfide ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Addition Reaction ◽  
Primary Amines ◽  
Oxidation Reactions ◽  
Michael Addition Reaction ◽  
Synthetic Utility ◽  
Reaction Proceeds

AbstractThiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeds via a domino alkylation/intramolecular Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions.

Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones via dual α′,α′-C(sp3)–H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones

2018 ◽  
Vol 16 (48) ◽  
pp. 9461-9471 ◽  
Author(s):  
Jiayong Zhang ◽  
Zhiwei Miao
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction

A sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones afforded cyclopentanone-fused spiro-pyrazolones catalyzed by DPPB via dual α′,α′-C(sp3)–H bifunctionalization.

scholarly journals A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells

Sensors ◽  
2017 ◽  
Vol 17 (2) ◽  
pp. 405 ◽  
Author(s):  
Zi-Hua Zheng ◽  
Zhi-Ke Li ◽  
Lin-Jiang Song ◽  
Qi-Wei Wang ◽  
Qing-Fei Huang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Aqueous Media ◽  
Living Cells ◽  
Sensitive Detection ◽  
Cyanide Ion
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