Stimuli-responsive metal–organic framework nanoparticles for controlled drug delivery and medical applications

2021 ◽  
Vol 50 (7) ◽  
pp. 4541-4563
Author(s):  
Zhixin Zhou ◽  
Margarita Vázquez-González ◽  
Itamar Willner
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Controlled Drug Delivery ◽  
Medical Applications ◽  
Stimuli Responsive ◽  
Metal Organic ◽  
Organic Framework

Different chemical, physical, and biomarker triggers to unlock the metal–organic framework nanoparticles and release the drugs loaded in the particles will be addressed.

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Ailing Feng ◽  
Yanni Wang ◽  
Jinzi Ding ◽  
Rong Xu ◽  
Xiaodong Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Direct Assembly ◽  
Metal Organic ◽  
Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

2018 ◽  
Vol 6 (1) ◽  
pp. 1801526 ◽  
Author(s):  
Wen Cai ◽  
Junqing Wang ◽  
Chengchao Chu ◽  
Wei Chen ◽  
Chunsheng Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Stimuli Responsive ◽  
Responsive Systems ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2038-2051 ◽  
Author(s):  
Weicong Liu ◽  
Ying Pan ◽  
Weiwei Xiao ◽  
Hongjia Xu ◽  
Dong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Review Article ◽  
The Body ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Stimulus Responsive ◽  
Recent Developments ◽  
Metal Organic ◽  
Organic Framework

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

β-Cyclodextrin-based Metal-Organic Framework as a Carrier for Zero-order Drug Delivery

2021 ◽  
pp. 129766
Author(s):  
Yanyi Li ◽  
Haobin Huang ◽  
Chongwei Ding ◽  
Xiaoping Zhou ◽  
Hong Li
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Zero Order ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Polymers

2021 ◽  
Vol 5 (4) ◽  
pp. 101
Author(s):  
Menglian Wei ◽  
Yu Wan ◽  
Xueji Zhang
Keyword(s):  
Metal Organic Framework ◽  
Chemical Properties ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Reversible Phase Transition ◽  
Metal Organic ◽  
External Stimuli ◽  
Organic Framework

Metal-organic framework (MOF) based stimuli-responsive polymers (coordination polymers) exhibit reversible phase-transition behavior and demonstrate attractive properties that are capable of altering physical and/or chemical properties upon exposure to external stimuli, including pH, temperature, ions, etc., in a dynamic fashion. Thus, their conformational change can be imitated by the adsorption/desorption of target analytes (guest molecules), temperature or pressure changes, and electromagnetic field manipulation. MOF-based stimuli responsive polymers have received great attention due to their advanced optical properties and variety of applications. Herein, we summarized some recent progress on MOF-based stimuli-responsive polymers (SRPs) classified by physical and chemical responsiveness, including temperature, pressure, electricity, pH, metal ions, gases, alcohol and multi-targets.

Cytotoxicity of a metal–organic framework: Drug delivery

2017 ◽  
Vol 77 ◽  
pp. 68-71 ◽  
Author(s):  
Aiqing Ma ◽  
Zhidong Luo ◽  
Chuying Gu ◽  
Baohong Li ◽  
Jianqiang Liu
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework
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