Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K/AKT pathway

2020 ◽  
Vol 11 (9) ◽  
pp. 7830-7841 ◽  
Author(s):  
Jingdi Zhan ◽  
Zijian Yan ◽  
Mengyao Zhao ◽  
Weihui Qi ◽  
Jian Lin ◽  
...  
Keyword(s):  
Femoral Head ◽  
Avascular Necrosis ◽  
Major Complication ◽  
Akt Pathway ◽  
Clinical Use ◽  
Osteoblast Apoptosis ◽  
Necrosis Of Femoral Head

Steroid-induced avascular necrosis of the femoral head (SANFH) is a major complication of long-term or excessive clinical use of glucocorticoids.

Membrane Microparticles from Patients with Steroid-Induced Avascular Necrosis of Femoral Head Increase the Expression of Fas in Endothelial Cells In Vitro.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3903-3903
Author(s):  
Xi-sheng Weng ◽  
Zhi-hong Wu ◽  
Yi Wei ◽  
Gui-xing Qiu
Keyword(s):  
Endothelial Cells ◽  
Femoral Head ◽  
Avascular Necrosis ◽  
Umbilical Vein ◽  
Cell Types ◽  
High Dose ◽  
Necrosis Of Femoral Head ◽  
Membrane Microparticles

Abstract High-dose or long-term usage of steroid have been suggested to be at great risk of developing avascular necrosis of femoral head (ANFH). A theory proposed to decipher the mechanism behind the development of steroid-induced ANFH involves vascular compromise and cell death. Membrane microparticles (MMPs) are fragments shed from plasma membrane blebs of virtually all cell types when submitted to a number of stress conditions, including apoptosis. It has been reported that high-dose dexamethasone cause dysfunction and apoptosis of endothelial cells; and MMPs isolated from the plasma of patients with myocardial infarction of preclampsia were found to cause damage in isolated arteries in vitro. We hypothesize that MMPs generated after high-dose or long-term administration of steroid facilitates the apoptosis of endothelial cells initiated by steroid, which contributes to the development of ANFH. MMPs were isolated from the blood of 4 healthy individuals, and 5 patients demonstrated to have ANFH by magnetic resonance imaging (MRI) and X-ray. The mean duration and accumulated dose of steroid administration were 8 months and 2000 mg respectively. The 3rd generation of human umbilical vein endothelial cells (HUVEC) was exposed to MMPs (corresponding to 0.2-fold circulating plasma level) prepared above. After 48 hours, part of cells was lysed to make total cell lysate. And the rest were used to prepare mRNA. The expression level of Fas was detected with reverse-transcript PCR and Western Blot. Our results shown that treatment of HUVEC with MMPs from ANFH patient’s blood significantly increases the transcription and expression of Fas, indicating that MMPs derived from patients with steroid-induced ANFH exacerbates high-dose steroid-induced apoptosis of endothelial cells by enhancing the expression of Fas.

Avascular Necrosis of Femoral Head: Findings of Contrast-Enhanced MR Imaging

1995 ◽  
Vol 32 (6) ◽  
pp. 953
Author(s):  
Young Min Kim ◽  
Hee Joong Kim ◽  
Heung Sik Kang ◽  
Chu Wan Kim ◽  
Yong Moon Shin
Keyword(s):  
Femoral Head ◽  
Mr Imaging ◽  
Avascular Necrosis ◽  
Contrast Enhanced ◽  
Necrosis Of Femoral Head

scholarly journals The results of core decompression treatment in patients with avascular necrosis of femoral head in patients at Isfahan City educational hospitals in 2010-2011

2014 ◽  
Vol 3 (1) ◽  
pp. 93 ◽  
Author(s):  
Mehdi Kooskzari ◽  
MehrabiKooshki Ali ◽  
Khalilollah Nazem ◽  
Behnamoon Mahsa ◽  
Mohammadreza Etemadifar
Keyword(s):  
Femoral Head ◽  
Avascular Necrosis ◽  
Core Decompression ◽  
Necrosis Of Femoral Head

scholarly journals Postoperative Collapse of Femoral Head in Patients with Rotational Osteotomy for Non-traumatic Avascular Necrosis of Femoral Head.

1999 ◽  
Vol 48 (1) ◽  
pp. 196-198
Author(s):  
Atsuhiko Wakisaka ◽  
Hiroshi Tanaka ◽  
Kenji Kide ◽  
Toru Moriwaki ◽  
Michio Shinohara ◽  
...  
Keyword(s):  
Femoral Head ◽  
Avascular Necrosis ◽  
Rotational Osteotomy ◽  
Necrosis Of Femoral Head

ROLE OF DASHMOOLADI MAJJA SNEHA (THERAPEUTIC ENEMA) IN AVASCULAR NECROSIS: A CASE STUDY

2021 ◽  
pp. 56-57
Author(s):  
Jakra Priyanka ◽  
Mishra Meenu ◽  
Soni Kamini
Keyword(s):  
Femoral Head ◽  
Avascular Necrosis ◽  
Classical Method ◽  
Symptomatic Relief ◽  
Modern Medicine ◽  
Neck Of Femur ◽  
Glucocorticoid Treatment ◽  
And Function ◽  
Necrosis Of Femoral Head

Introduction:Avascular necrosis is also known as aseptic, osteonecrosis and ischaemic necrosis of bone. There are a multitude of risk factors but over 80% of cases are attributed to glucocorticoid treatment or alcohol excess. Avascular Necrosis of femoral head is the most common type of necrosis, because the artery supplying to neck of femur is very narrow which easily gets injured. In modern medicine there is no specic treatment rather than surgery. In Ayurveda avascular necrosis can be correlated with Asthimajjagatvata. Aim: To assess the efcacy of Dashmooladi Majja Sneha in the management of avascular necrosis. The objective of the treatment includes the preservation of structure and function of hip joint with symptomatic relief. Materials & Methods:The present case study is upon a 32 year old, diagnosed case of avascular necrosis of femoral head with complaints of pain in bilateral sacroiliac joint since one and half years which was associated with difculty in doing normal daily activities such as walking, sitting, squatting along with change in the gait, at the Panchakarma OPD of Govt. Ayurvedic hospital Bhopal. The patient of idiopathic AVN of femoral head was treated with Dashmooladi Majja Sneha, Brihatvata Chintamani Rasa, Amritaristha, Panchtikta Ghrita Guggulu and Shastik Shali Pind Swedan have done as per the classical method for 30 days. Assessment was done after treatment and follow up after 15 days for 2months. Observations: The Ayurvedic therapies and oral medicines yielded complete symptomatic relief from pain, general debility and improvement in the gait. Conclusion: On the basis of the results obtained it can be concluded that Dashmooladi Majja Sneha, Shastik Shali Pind Swedan and some oral medicines can be used as an effective treatment in the management of Avascular Necrosis.

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