An Oxidant- and Catalyst-Free Electrooxidative Cross-Coupling Approach to 3-Tetrahydroisoquinoline Substituted Coumarins

2021 ◽  
Author(s):  
Yanyan Kong ◽  
Jung Keun Kim ◽  
Yabo Li ◽  
Jianye Zhang ◽  
Mengmeng Huang ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Fast Method ◽  
Catalyst Free ◽  
Dehydrogenative Coupling ◽  
Coupling Approach ◽  
Substituted Coumarins

A direct electrooxidative cross-dehydrogenative-coupling (CDC) reaction between N-aryl-tetrahydroisoquinolines and 4-hydroxycoumarins has been developed. This protocol provides a green, mild and fast method to construct 3-tetrahydroisoquinoline substituted coumarins in the absence...

Copper-catalyzed acyloxylation of the C(sp3)–H bond adjacent to an oxygen by a cross-dehydrogenative coupling approach

RSC Advances ◽  
2014 ◽  
Vol 4 (92) ◽  
pp. 50795-50800 ◽  
Author(s):  
Kammari Bal Raju ◽  
Bejjanki Naveen Kumar ◽  
Kommu Nagaiah
Keyword(s):  
Benzyl Alcohol ◽  
Cross Coupling ◽  
Benzyl Alcohols ◽  
Dehydrogenative Coupling ◽  
New Strategy ◽  
Coupling Approach ◽  
Direct Use

We demonstrated a dehydrogenative cross coupling between a benzyl alcohol and C(sp3)–H bond for the construction of a C–O bond. This method reveals a new strategy for the direct use of benzyl alcohols in the synthesis of esters with the use of copper as a catalyst and TBHP as an oxidant.

Transition-Metal-Free Synthetic Strategies for the Cross-Coupling Reactions in Water: A Green Approach

2020 ◽  
Vol 07 ◽  
Author(s):  
Tanmay Chatterjee ◽  
Nilanjana Mukherjee
Keyword(s):  
Transition Metal ◽  
Organic Solvents ◽  
Aqueous Media ◽  
Cross Coupling ◽  
Transition Metal Catalysts ◽  
Synthetic Methods ◽  
Coupling Reactions ◽  
Organic Transformations ◽  
Green Approach ◽  
Dehydrogenative Coupling

Abstract: A natural driving force is always working behind the synthetic organic chemists towards the development of ‘green’ synthetic methodologies for the synthesis of useful classes of organic molecules having potential applications. The majority of the essential classes of organic transformations, including C-C and C-X (X = heteroatom) bond-forming crosscoupling reactions, cross dehydrogenative-coupling (CDC) mostly rely on the requirement of transition-metal catalysts and hazardous organic solvents. Hence, the scope in developing green synthetic strategies by avoiding the use of transitionmetal catalysts and hazardous organic solvents for those important and useful classes of organic transformations is very high. Hence, several attempts are made so far. Water being the most abundant, cheap, and green solvent in the world; numerous synthetic methods have been developed in an aqueous medium. In this review, the development of transitionmetal- free green synthetic strategies for various important classes of organic transformations such as C-C and C-X bondforming cross-coupling, cross dehydrogenative-coupling, and oxidative-coupling in an aqueous media is discussed.

scholarly journals A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes

2021 ◽  
Author(s):  
F. Wieland Goetzke ◽  
Alexander M. L. Hell ◽  
Lucy van Dijk ◽  
Stephen P. Fletcher
Keyword(s):  
Cross Coupling ◽  
Coupling Approach ◽  
Catalytic Asymmetric

Atmospheric oxidative catalyst-free cross-dehydrogenative coupling of aldehydes with N -hydroxyimides

2017 ◽  
Vol 58 (18) ◽  
pp. 1742-1746 ◽  
Author(s):  
Xiaohe Xu ◽  
Pingping Li ◽  
Yingyi Huang ◽  
Chuo Tong ◽  
YiYan Yan ◽  
...  
Keyword(s):  
Catalyst Free ◽  
Dehydrogenative Coupling

Direct C–H cross-coupling approach to heteroaryl coumarins

2012 ◽  
Vol 10 (13) ◽  
pp. 2692 ◽  
Author(s):  
Minsik Min ◽  
Bomi Kim ◽  
Sungwoo Hong
Keyword(s):  
Cross Coupling ◽  
Coupling Approach

Ir-catalyzed selective dehydrogenative cross-coupling of aryls with o-carboranes via a mixed directing-group strategy

2020 ◽  
Vol 56 (51) ◽  
pp. 7001-7004 ◽  
Author(s):  
Yu Chen ◽  
Yangjian Quan ◽  
Zuowei Xie
Keyword(s):  
Cross Coupling ◽  
Group Strategy ◽  
Dehydrogenative Coupling ◽  
Directing Group

Ir-catalyzed highly selective B–H/C–H cross dehydrogenative coupling between o-carboranes and (hetero)aryls has been achieved using a mixed directing-group strategy.

scholarly journals Aryne Reaction and Cross-coupling Approach for the Synthesis of Diverse N-Arylphenylalanine Derivatives

2020 ◽  
Vol 49 (7) ◽  
pp. 809-812
Author(s):  
Tsuneyuki Kobayashi ◽  
Takamitsu Hosoya ◽  
Suguru Yoshida
Keyword(s):  
Cross Coupling ◽  
Coupling Approach

Radical alkylation of C(sp3)–H bonds with diacyl peroxides under catalyst-free conditions

2019 ◽  
Vol 55 (98) ◽  
pp. 14813-14816 ◽  
Author(s):  
Hao Tian ◽  
Wentao Xu ◽  
Yuxiu Liu ◽  
Qingmin Wang
Keyword(s):  
Alkyl Radical ◽  
Cross Coupling ◽  
Catalyst Free ◽  
Alkylation Reactions

Herein, we describe a protocol for alkylation reactions of C(sp3)–H bonds with diacyl peroxides by means of a process involving cross-coupling between an alkyl radical and an α-aminoalkyl radical.

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