scholarly journals Magic-angle spinning NMR spectroscopy provides insight into the impact of small molecule uptake by G-quartet hydrogels

2020 ◽  
Vol 1 (7) ◽  
pp. 2236-2247
Author(s):  
G. N. Manjunatha Reddy ◽  
Gretchen M. Peters ◽  
Ben P. Tatman ◽  
Teena S. Rajan ◽  
Si Min Kock ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecules ◽  
Small Molecule ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Local Structures ◽  
Angle Spinning ◽  
The Impact ◽  
Insight Into

Compositions, local structures and interactions of medicinally relevant small molecules added to G-quartet hydrogels are characterized using gel-state NMR spectroscopy.

scholarly journals Magic-angle-spinning NMR spectroscopy applied to small molecules and peptides in lipid bilayers

2007 ◽  
Vol 35 (5) ◽  
pp. 991-995 ◽  
Author(s):  
C. Ader ◽  
R. Schneider ◽  
K. Seidel ◽  
M. Etzkorn ◽  
M. Baldus
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecules ◽  
Lipid Bilayers ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Domain Formation ◽  
Structure And Dynamics ◽  
Molecular Complexation ◽  
Angle Spinning ◽  
Insight Into

ssNMR (solid-state NMR) spectroscopy provides increasing possibilities to study the structural and dynamic aspects of biological membranes. Here, we review recent ssNMR experiments that are based on MAS (magic angle spinning) and that provide insight into the structure and dynamics of membrane systems at the atomic level. Such methods can be used to study membrane architecture, domain formation or molecular complexation in a way that is highly complementary to other biophysical methods such as imaging or calorimetry.

scholarly journals Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

PLoS Biology ◽  
2018 ◽  
Vol 16 (5) ◽  
pp. e2006192 ◽  
Author(s):  
Daniel Stöppler ◽  
Alex Macpherson ◽  
Susanne Smith-Penzel ◽  
Nicolas Basse ◽  
Fabien Lecomte ◽  
...  
Keyword(s):  
Small Molecule ◽  
Magic Angle Spinning ◽  
Fc Receptor ◽  
Magic Angle ◽  
Neonatal Fc Receptor ◽  
X Ray ◽  
X Ray Crystallography ◽  
Angle Spinning ◽  
Insight Into

Applications of high resolution magic angle spinning NMR spectroscopy in tumor metabonomics research

2013 ◽  
Vol 32 (9) ◽  
pp. 1024-1027
Author(s):  
Yu LI ◽  
Jing-xia ZHAO ◽  
Gen-jin YANG ◽  
Wei ZHANG ◽  
Zi-yang LOU
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Angle Spinning

Wideline 2H -NMR Spectroscopy and Imaging of Solids

1994 ◽  
Vol 49 (1-2) ◽  
pp. 19-26 ◽  
Author(s):  
B. Blümich
Keyword(s):  
Nmr Spectroscopy ◽  
Excitation Power ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
2H Nmr ◽  
Stochastic Excitation ◽  
2H Nmr Spectroscopy ◽  
Spatially Inhomogeneous ◽  
Recent Developments ◽  
Angle Spinning

Abstract Recent developments, focussing on reduction of the rf excitation power by stochastic excitation, on improvements in sensitivity and excitation bandwidth by magic angle spinning, and on combining wideline spectroscopy with spatial resolution for investigations o f spatially inhomogeneous objects are reviewed.

scholarly journals Sampling Method Affects HR-MAS NMR Spectra of Healthy Caprine Brain Biopsies

Metabolites ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 38
Author(s):  
Annakatrin Häni ◽  
Gaëlle Diserens ◽  
Anna Oevermann ◽  
Peter Vermathen ◽  
Christina Precht
Keyword(s):  
Nmr Spectroscopy ◽  
Sampling Method ◽  
Magic Angle Spinning ◽  
Mas Nmr ◽  
Magic Angle ◽  
1H Nuclear Magnetic Resonance ◽  
Rapid Changes ◽  
Tissue Degradation ◽  
Angle Spinning

The metabolic profiling of tissue biopsies using high-resolution–magic angle spinning (HR-MAS) 1H nuclear magnetic resonance (NMR) spectroscopy may be influenced by experimental factors such as the sampling method. Therefore, we compared the effects of two different sampling methods on the metabolome of brain tissue obtained from the brainstem and thalamus of healthy goats by 1H HR-MAS NMR spectroscopy—in vivo-harvested biopsy by a minimally invasive stereotactic approach compared with postmortem-harvested sample by dissection with a scalpel. Lactate and creatine were elevated, and choline-containing compounds were altered in the postmortem compared to the in vivo-harvested samples, demonstrating rapid changes most likely due to sample ischemia. In addition, in the brainstem samples acetate and inositols, and in the thalamus samples ƴ-aminobutyric acid, were relatively increased postmortem, demonstrating regional differences in tissue degradation. In conclusion, in vivo-harvested brain biopsies show different metabolic alterations compared to postmortem-harvested samples, reflecting less tissue degradation. Sampling method and brain region should be taken into account in the analysis of metabolic profiles. To be as close as possible to the actual situation in the living individual, it is desirable to use brain samples obtained by stereotactic biopsy whenever possible.

Pulsed Field Gradient Selection in Two-Dimensional Magic Angle Spinning NMR Spectroscopy of Dipolar Solids

1998 ◽  
Vol 134 (2) ◽  
pp. 355-359 ◽  
Author(s):  
Tilo Fritzhanns ◽  
Siegfried Hafner ◽  
Dan E. Demco ◽  
Hans W. Spiess ◽  
Frank H. Laukien
Keyword(s):  
Nmr Spectroscopy ◽  
Field Gradient ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Two Dimensional ◽  
Pulsed Field ◽  
Angle Spinning
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