scholarly journals Magic-angle-spinning NMR spectroscopy applied to small molecules and peptides in lipid bilayers

2007 ◽  
Vol 35 (5) ◽  
pp. 991-995 ◽  
Author(s):  
C. Ader ◽  
R. Schneider ◽  
K. Seidel ◽  
M. Etzkorn ◽  
M. Baldus
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecules ◽  
Lipid Bilayers ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Domain Formation ◽  
Structure And Dynamics ◽  
Molecular Complexation ◽  
Angle Spinning ◽  
Insight Into

ssNMR (solid-state NMR) spectroscopy provides increasing possibilities to study the structural and dynamic aspects of biological membranes. Here, we review recent ssNMR experiments that are based on MAS (magic angle spinning) and that provide insight into the structure and dynamics of membrane systems at the atomic level. Such methods can be used to study membrane architecture, domain formation or molecular complexation in a way that is highly complementary to other biophysical methods such as imaging or calorimetry.

scholarly journals Magic-angle spinning NMR spectroscopy provides insight into the impact of small molecule uptake by G-quartet hydrogels

2020 ◽  
Vol 1 (7) ◽  
pp. 2236-2247
Author(s):  
G. N. Manjunatha Reddy ◽  
Gretchen M. Peters ◽  
Ben P. Tatman ◽  
Teena S. Rajan ◽  
Si Min Kock ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecules ◽  
Small Molecule ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Local Structures ◽  
Angle Spinning ◽  
The Impact ◽  
Insight Into

Compositions, local structures and interactions of medicinally relevant small molecules added to G-quartet hydrogels are characterized using gel-state NMR spectroscopy.

scholarly journals Probing Structure and Dynamics of Protein Assemblies by Magic Angle Spinning NMR Spectroscopy

2013 ◽  
Vol 46 (9) ◽  
pp. 2047-2058 ◽  
Author(s):  
Si Yan ◽  
Christopher L. Suiter ◽  
Guangjin Hou ◽  
Huilan Zhang ◽  
Tatyana Polenova
Keyword(s):  
Nmr Spectroscopy ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Protein Assemblies ◽  
Structure And Dynamics ◽  
Angle Spinning

Tethered or Adsorbed Supported Lipid Bilayers in Nanotubes Characterized by Deuterium Magic Angle Spinning NMR Spectroscopy

Langmuir ◽  
2005 ◽  
Vol 21 (8) ◽  
pp. 3226-3228 ◽  
Author(s):  
Olivier Wattraint ◽  
Dror E. Warschawski ◽  
Catherine Sarazin
Keyword(s):  
Nmr Spectroscopy ◽  
Lipid Bilayers ◽  
Magic Angle Spinning ◽  
Supported Lipid Bilayers ◽  
Magic Angle ◽  
Angle Spinning

Determination of Membrane Protein Structure and Dynamics by Magic-Angle-Spinning Solid-State NMR Spectroscopy†

2005 ◽  
Vol 127 (37) ◽  
pp. 12965-12974 ◽  
Author(s):  
Ovidiu C. Andronesi ◽  
Stefan Becker ◽  
Karsten Seidel ◽  
Henrike Heise ◽  
Howard S. Young ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Membrane Protein Structure ◽  
Structure And Dynamics ◽  
Angle Spinning ◽  
Protein Structure And Dynamics

scholarly journals Ellagitannin–Lipid Interaction by HR-MAS NMR Spectroscopy

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 373
Author(s):  
Valtteri Virtanen ◽  
Susanna Räikkönen ◽  
Elina Puljula ◽  
Maarit Karonen
Keyword(s):  
Nmr Spectroscopy ◽  
Lipid Bilayers ◽  
Membrane Lipids ◽  
Nuclear Overhauser Effect ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Relaxation Rates ◽  
Lipid Mixture ◽  
Nuclear Overhauser ◽  
Angle Spinning

Ellagitannins have antimicrobial activity, which might be related to their interactions with membrane lipids. We studied the interactions of 12 different ellagitannins and pentagalloylglucose with a lipid extract of Escherichia coli by high-resolution magic angle spinning NMR spectroscopy. The nuclear Overhauser effect was utilized to measure the cross relaxation rates between ellagitannin and lipid protons. The shifting of lipid signals in 1H NMR spectra of ellagitannin–lipid mixture due to ring current effect was also observed. The ellagitannins that showed interaction with lipids had clear structural similarities. All ellagitannins that had interactions with lipids had glucopyranose cores. In addition to the central polyol, the most important structural feature affecting the interaction seemed to be the structural flexibility of the ellagitannin. Even dimeric and trimeric ellagitannins could penetrate to the lipid bilayers if their structures were flexible with free galloyl and hexahydroxydiphenoyl groups.

Applications of high resolution magic angle spinning NMR spectroscopy in tumor metabonomics research

2013 ◽  
Vol 32 (9) ◽  
pp. 1024-1027
Author(s):  
Yu LI ◽  
Jing-xia ZHAO ◽  
Gen-jin YANG ◽  
Wei ZHANG ◽  
Zi-yang LOU
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Angle Spinning
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