scholarly journals Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition

2020 ◽  
Vol 11 (11) ◽  
pp. 1295-1302
Author(s):  
Kesari Lakshmi Manasa ◽  
Sowjanya Thatikonda ◽  
Dilep Kumar Sigalapalli ◽  
Sowmya Vuppaladadium ◽  
Ganthala Parimala Devi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Proliferative Potential ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Substituted 1

Herein, we have designed and synthesized a library of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone derivatives (10aa–ef) and evaluated for their anti-proliferative potential against a panel of human cancer cell lines.

scholarly journals New imidazo[2,1-b]thiazole-based aryl hydrazones: unravelling their synthesis and antiproliferative and apoptosis-inducing potential

2020 ◽  
Vol 11 (10) ◽  
pp. 1178-1184
Author(s):  
Mohd Adil Shareef ◽  
Ganthala Parimala Devi ◽  
Sunitha Rani Routhu ◽  
C. Ganesh Kumar ◽  
Ahmed Kamal ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Proliferative Potential ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Herein, we have designed and synthesized new imidazo[2,1-b]thiazole-based aryl hydrazones (9a–w) and evaluated their anti-proliferative potential against a panel of human cancer cell lines.

Pyrazole–oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization

2014 ◽  
Vol 12 (40) ◽  
pp. 7993-8007 ◽  
Author(s):  
Ahmed Kamal ◽  
Anver Basha Shaik ◽  
Sowjanya Polepalli ◽  
Vangala Santosh Reddy ◽  
G. Bharath Kumar ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A library of pyrazole–oxadiazole conjugates were synthesized and investigated for their antiproliferative activity in human cancer cell lines.

ChemInform Abstract: Design and Synthesis of C35-Fluorinated Solamins and Their Growth Inhibitory Activities Against Human Cancer Cell Lines.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Naoto Kojima ◽  
Yuki Suga ◽  
Hiromi Hayashi ◽  
Takao Yamori ◽  
Takehiko Yoshimitsu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Growth Inhibitory ◽  
Inhibitory Activities

scholarly journals Design and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIα inhibition

MedChemComm ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 72-79 ◽  
Author(s):  
N. Sankara Rao ◽  
Narayana Nagesh ◽  
V. Lakshma Nayak ◽  
Satish Sunkari ◽  
Ramya Tokala ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Topoisomerase Iiα ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis

A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their in vitro cytotoxicity on selected human cancer cell lines.

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

2015 ◽  
Vol 13 (40) ◽  
pp. 10162-10178 ◽  
Author(s):  
Ahmed Kamal ◽  
Anver Basha Shaik ◽  
Bala Bhaskara Rao ◽  
Irfan Khan ◽  
G. Bharath Kumar ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Antiproliferative Agents ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

A series of pyrazole/isoxazole linked arylcinnamide conjugates were synthesized and investigated for their cytotoxic activity against a panel of four human cancer cell lines. Most of them have shown significant cytotoxicity apart from potential tubulin depolymerization activity.

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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