Stimulus-responsive conformational transformation of peptide with cell penetrating motif for triggered cytotoxicity

2020 ◽  
Vol 44 (45) ◽  
pp. 19734-19741
Author(s):  
Jeonghun Lee ◽  
Eun-Taex Oh ◽  
Ye-eun Joo ◽  
Ha Gyeong Kim ◽  
Heon Joo Park ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Disulfide Bond ◽  
Conformational Transformation ◽  
Intracellular Uptake ◽  
Selective Cytotoxicity ◽  
Intramolecular Disulfide Bond ◽  
Stimulus Responsive ◽  
Cell Penetrating ◽  
A Cell

A modified KLA peptide with an intramolecular disulfide bond and a cell penetrating sequence is developed for enhanced intracellular uptake and triggered selective cytotoxicity towards cancer cells by stimulus-responsive conformational transformation.

A Cell-Penetrating Peptide Targeting AAC-11 Specifically Induces Cancer Cells Death

2016 ◽  
Vol 76 (18) ◽  
pp. 5479-5490 ◽  
Author(s):  
Léonard Jagot-Lacoussiere ◽  
Ewa Kotula ◽  
Bruno O. Villoutreix ◽  
Heriberto Bruzzoni-Giovanelli ◽  
Jean-Luc Poyet
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell ◽  
Peptide Targeting ◽  
Cells Death

Abstract 4220: A cell-penetrating nucleolytic lupus autoantibody damages DNA and is toxic to BRCA2-deficient cancer cells

2014 ◽  
Author(s):  
Philip W. Noble ◽  
Melissa R. Young ◽  
Richard H. Weisbart ◽  
James E. Hansen
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating ◽  
A Cell

scholarly journals Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide

2014 ◽  
Vol 5 (7) ◽  
pp. 809-814 ◽  
Author(s):  
Anna Leonidova ◽  
Vanessa Pierroz ◽  
Luke A. Adams ◽  
Nicholas Barlow ◽  
Stefano Ferrari ◽  
...  
Keyword(s):  
Cell Penetrating ◽  
A Cell

18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells

2012 ◽  
Vol 39 (8) ◽  
pp. 1202-1212 ◽  
Author(s):  
Susan Richter ◽  
Vincent Bouvet ◽  
Melinda Wuest ◽  
Ralf Bergmann ◽  
Joerg Steinbach ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cell Uptake ◽  
Cell Penetrating Peptide ◽  
Human Cancer Cells ◽  
Cell Penetrating
Sign in / Sign up

Export Citation Format

Share Document