scholarly journals Construction of all-carbon quaternary stereocenters by catalytic asymmetric conjugate addition to cyclic enones in natural product synthesis

2020 ◽  
Vol 7 (22) ◽  
pp. 3815-3841
Author(s):  
Zhuo Wang
Keyword(s):  
Natural Product ◽  
Conjugate Addition ◽  
Natural Product Synthesis ◽  
Cyclic Enones ◽  
Catalytic Asymmetric ◽  
Quaternary Stereocenters

This review discusses the construction of all-carbon quaternary stereocenters using catalytic asymmetric conjugate addition and its application in natural product synthesis.

Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B

2014 ◽  
Vol 12 (31) ◽  
pp. 5883-5890 ◽  
Author(s):  
Jeffrey Buter ◽  
Renée Moezelaar ◽  
Adriaan J. Minnaard
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Conjugate Addition ◽  
Natural Product Synthesis ◽  
Conjugate Additions ◽  
Arylboronic Acids ◽  
Cyclic Enones ◽  
Palladium Catalyzed

Palladium catalyzed asymmetric conjugate addition of ortho-substituted arylboronic acids to cyclic enones and its application in natural product synthesis.

scholarly journals Catalytic Asymmetric Intramolecular Darzens Reaction of 2-Halomalonate Derivatives

2019 ◽  
Vol 14 (10) ◽  
pp. 1934578X1988440
Author(s):  
Kenichi Kobayashi ◽  
Kosaku Tanaka ◽  
Momoko Suzuki ◽  
Hiroshi Kogen
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Phase Transfer ◽  
Building Blocks ◽  
Natural Product Synthesis ◽  
Darzens Reaction ◽  
Phase Transfer Catalysts ◽  
Catalytic Asymmetric

A catalytic asymmetric intramolecular Darzens reaction of 2-halomalonate derivatives was developed for the enantioselective preparation of chiral building blocks for epoxide-containing natural products. Among the screened catalysts, some phase-transfer catalysts gave the desired epoxide in moderate enantioselectivity, albeit in low yield. The epoxide product would be useful as versatile chiral building blocks for natural product synthesis.

Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

2015 ◽  
Vol 32 (11) ◽  
pp. 1584-1601 ◽  
Author(s):  
Rong Long ◽  
Jun Huang ◽  
Jianxian Gong ◽  
Zhen Yang
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Pharmacological Activities ◽  
Direct Construction ◽  
Quaternary Stereocenters ◽  
Biological And Pharmacological Activities

Molecules containing vicinal all-carbon quaternary stereocenters are found in many secondary metabolites, and they exhibit a variety of biological and pharmacological activities.

A catalytic route to acyclic chiral building blocks: Applications of the catalytic asymmetric conjugate addition of organozinc reagents to cyclic enones

2001 ◽  
Vol 41 (4) ◽  
pp. 221-230 ◽  
Author(s):  
Richard B. C. Jagt ◽  
Rosalinde Imbos ◽  
Robert Naasz ◽  
Adriaan J. Minnaard ◽  
Ben L. Feringa
Keyword(s):  
Conjugate Addition ◽  
Building Blocks ◽  
Cyclic Enones ◽  
Catalytic Asymmetric ◽  
Organozinc Reagents
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