scholarly journals Chitosan-covered liposomes as a promising drug transporter: nanoscale investigations

RSC Advances ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 1503-1516
Author(s):  
Lemaalem Mohammed ◽  
Hadrioui Nourddine ◽  
El Fassi Saad ◽  
Derouiche Abdelali ◽  
Ridouane Hamid
Keyword(s):  
Membrane Structure ◽  
Molar Fraction ◽  
Drug Transporter ◽  
Liposome Membrane ◽  
Structure And Dynamics

In this paper, we studied the graft chitosan conformation and its influence on the liposome membrane structure and dynamics as a function of the grafting molar-fraction.

Pressure effects on lipid membrane structure and dynamics

2011 ◽  
Vol 164 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Nicholas J. Brooks ◽  
Oscar Ces ◽  
Richard H. Templer ◽  
John M. Seddon
Keyword(s):  
Membrane Structure ◽  
Lipid Membrane ◽  
Pressure Effects ◽  
Structure And Dynamics

scholarly journals Mitotane directly interacts with lipid membranes and alters membrane structure and dynamics

2015 ◽  
Author(s):  
Peter Muller ◽  
Stephan Theisgen ◽  
Andreas Schirbel ◽  
Silviu Sbiera ◽  
Ivan Haralampiev ◽  
...  
Keyword(s):  
Lipid Membranes ◽  
Membrane Structure ◽  
Structure And Dynamics

scholarly journals Surface Roughness and Palmitoylation of Transmembrane Helices Influence Membrane Structure and Dynamics

2019 ◽  
Vol 116 (3) ◽  
pp. 89a
Author(s):  
Adéla Melcrová ◽  
Marie Olšinová ◽  
Marek Cebecauer ◽  
Lukasz Cwiklik
Keyword(s):  
Surface Roughness ◽  
Membrane Structure ◽  
Transmembrane Helices ◽  
Structure And Dynamics

scholarly journals Structure and Dynamics of Glycosphingolipids in Lipid Bilayers: Insights from Molecular Dynamics Simulations

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ronak Y. Patel ◽  
Petety V. Balaji
Keyword(s):  
Molecular Dynamics ◽  
Lipid Bilayers ◽  
Membrane Structure ◽  
Lipid Membrane ◽  
Biological Membranes ◽  
Md Simulations ◽  
Atomic Level ◽  
Structure And Dynamics ◽  
Hydrogen Bonding Interactions ◽  
Dynamics Simulations

Glycolipids are important constituents of biological membranes, and understanding their structure and dynamics in lipid bilayers provides insights into their physiological and pathological roles. Experimental techniques have provided details into their behavior at model and biological membranes; however, computer simulations are needed to gain atomic level insights. This paper summarizes the insights obtained from MD simulations into the conformational and orientational dynamics of glycosphingolipids and their exposure, hydration, and hydrogen-bonding interactions in membrane environment. The organization of glycosphingolipids in raft-like membranes and their modulation of lipid membrane structure are also reviewed.

MOLECULAR DYNAMICS SIMULATION ON THE STRUCTURE AND DYNAMICS OF WATER IN THE 1-BUTYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE/WATER MIXTURE

2010 ◽  
Vol 09 (03) ◽  
pp. 573-584 ◽  
Author(s):  
GUOCAI TIAN ◽  
JIAN LI
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Pure Water ◽  
Molar Fraction ◽  
Blue Shift ◽  
Dynamics Simulation ◽  
Water Molecules ◽  
Water Mixture ◽  
Structure And Dynamics ◽  
Hydrogen Bond Interactions

The micro-structure, and IR spectrum of water molecules in 1-butyl-3-methylimi- dazolium tetrafluoroborate( [Bmim]BF4 )/water mixture with different concentrations (x1 = 25.0%, 50.0%, 75.0%, and 90.0%) were studied with molecular dynamics simulation at room temperature. It was shown that water molecules tend to be isolated from each other in mixtures with more ions than water molecules in pure water. With the increase of the molar fraction of water in the mixture, the rotation bands and the bending bands of water display red shift from 566.2 to 651.4 cm-1 and from 1638.4 to 1683.2 cm-1 respectively, whereas the O–H stretch bands show blue shift from 3519.8 to 3452 cm-1, which agree well with the experimental results. This suggests that the molecules are hindered and their motions are difficult and slow, due to the hydrogen-bond interactions and the inharmonic interactions between the inter- or intra-molecular modes of water molecules.

scholarly journals Effects of Antibacterial Peptide F1 on Bacterial Liposome Membrane Integrity

2021 ◽  
Vol 8 ◽  
Author(s):  
Qun Wang ◽  
Bo Peng ◽  
Mingyue Song ◽  
Abdullah ◽  
Jun Li ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Membrane Structure ◽  
Bacterial Membrane ◽  
Phospholipid Membranes ◽  
Phospholipid Membrane ◽  
Gram Positive ◽  
Liposome Membrane ◽  
Gram Negative ◽  
Bacterial Membranes ◽  
Gram Positive Bacteria

Previous studies from our lab have shown that the antimicrobial peptide F1 obtained from the milk fermentation by Lactobacillus paracasei FX-6 derived from Tibetan kefir was different from common antimicrobial peptides; specifically, F1 simultaneously inhibited the growth of Gram-negative and Gram-positive bacteria. Here, we present follow-on work demonstrating that after the antimicrobial peptide F1 acts on either Escherichia coli ATCC 25922 (E. coli) or Staphylococcus aureus ATCC 63589 (S. aureus), their respective bacterial membranes were severely deformed. This deformation allowed leakage of potassium and magnesium ions from the bacterial membrane. The interaction between the antimicrobial peptide F1 and the bacterial membrane was further explored by artificially simulating the bacterial phospholipid membranes and then extracting them. The study results indicated that after the antimicrobial peptide F1 interacted with the bacterial membranes caused significant calcein leakage that had been simulated by different liposomes. Furthermore, transmission electron microscopy observations revealed that the phospholipid membrane structure was destroyed and the liposomes presented aggregation and precipitation. Quartz Crystal Microbalance with Dissipation (QCM-D) results showed that the antimicrobial peptide F1 significantly reduced the quality of liposome membrane and increased their viscoelasticity. Based on the study's findings, the phospholipid membrane particle size was significantly increased, indicating that the antimicrobial peptide F1 had a direct effect on the phospholipid membrane. Conclusively, the antimicrobial peptide F1 destroyed the membrane structure of both Gram-negative and Gram-positive bacteria by destroying the shared components of their respective phospholipid membranes which resulted in leakage of cell contents and subsequently cell death.

Effects of lipid supplementation of culture media on cell growth, antibody production, membrane structure and dynamics in two hybridomas

1996 ◽  
Vol 48 (1-2) ◽  
pp. 161-173 ◽  
Author(s):  
Sandrine Savonnière ◽  
Nezha Zeghari ◽  
Laurent Miccoli ◽  
Sylvaine Muller ◽  
michel Maugras ◽  
...  
Keyword(s):  
Cell Growth ◽  
Antibody Production ◽  
Membrane Structure ◽  
Culture Media ◽  
Structure And Dynamics ◽  
Lipid Supplementation
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