Recent research and development of local anesthetic-loaded microspheres

2020 ◽  
Vol 8 (30) ◽  
pp. 6322-6332
Author(s):  
Yi Wei ◽  
Youbin Wu ◽  
Kang Wen ◽  
Nardana Bazybek ◽  
Guanghui Ma
Keyword(s):  
Research And Development ◽  
Local Anesthetic ◽  
Release Rate ◽  
Preparation Method ◽  
High Loading ◽  
Loading Efficiency

This review introduces the recent research and development in local anesthetic-loaded microsphere, as efficient microspheres formulation, the efficient microspheres: optimum preparation method, high loading efficiency, and ideal release rate.

scholarly journals High Loading Efficiency and Controlled Release of Bioactive Immunotherapeutic Proteins Using Vaterite Nanoparticles (Part. Part. Syst. Charact. 7/2021)

2021 ◽  
Vol 38 (7) ◽  
pp. 2170013
Author(s):  
Ghizlane Choukrani ◽  
Jimena Álvarez Freile ◽  
Natasha Ustyanovska Avtenyuk ◽  
Wei Wan ◽  
Kerstin Zimmermann ◽  
...  
Keyword(s):  
Controlled Release ◽  
High Loading ◽  
Loading Efficiency

Design and synthesis of periodic mesoporous organosilica materials with a multi-compartment structure

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89397-89406 ◽  
Author(s):  
Chun Xiang Cynthia Lin ◽  
Siddharth Jambhrunkar ◽  
Pei Yuan ◽  
Chun Hui Clayton Zhou ◽  
George Xiu Song Zhao
Keyword(s):  
Anticancer Drug ◽  
Release Rate ◽  
Slow Release ◽  
Drug Carrier ◽  
High Loading ◽  
Loading Capacity ◽  
Periodic Mesoporous Organosilica ◽  
Design And Synthesis ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Multi-compartment periodic mesoporous organosilica materials show desirable properties as anticancer drug carrier with high loading capacity and slow release rate.

scholarly journals High Loading Efficiency and Controlled Release of Bioactive Immunotherapeutic Proteins Using Vaterite Nanoparticles

2021 ◽  
pp. 2100012
Author(s):  
Ghizlane Choukrani ◽  
Jimena Álvarez Freile ◽  
Natasha Ustyanovska Avtenyuk ◽  
Wei Wan ◽  
Kerstin Zimmermann ◽  
...  
Keyword(s):  
Controlled Release ◽  
High Loading ◽  
Loading Efficiency

Preparation and Performance of Controlled-Release Tablets of Sasanquasaponin-Sodium Alginate-Hydroxypropyl Methyl Cellulose

2014 ◽  
Vol 884-885 ◽  
pp. 494-497
Author(s):  
Xiao Zhou Liu ◽  
Xiao Zhen Liu ◽  
Zhong Fang Lai ◽  
Yue Xing Song ◽  
Li Zhai
Keyword(s):  
Controlled Release ◽  
Sodium Alginate ◽  
Release Rate ◽  
Preparation Method ◽  
Methyl Cellulose ◽  
Zero Order ◽  
Chemical Bonds ◽  
Hydroxypropyl Methyl Cellulose ◽  
And Performance ◽  
Controlled Release Tablets

The controlled-release tablets of sasanquasaponin-sodium alginate-hydroxy-propyl methyl cellulose (SQS-SAL-HPMC) were prepared by using SQS, SAL and HPMC as the main drug and accessories. The effects of the preparation method of the controlled-release powder and the amount of ethanol on release rate respectively were studied. The release rate curve of the data of the prescription of the controlled-release tablets of SQS-SAL-HPMC were fitted as zero order, one order and Higuchi equation. The controlled-release tablet of SQS-SAL-HPMC was characterized by IR techniques. The releasing rate of the controlled-release tablets of SQS-SAL-HPMC are controlled by controlling the preparation method of the controlled-release powder and the amount of ethanol. The controlled- release tablets of SQS-SAL-HPMC release SQS by slowness and constant in 12h. The chemical bonds are formed among SQS, SAL and HPMC.

scholarly journals Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1322
Author(s):  
Bijuli Rabha ◽  
Kaushik Kumar Bharadwaj ◽  
Debabrat Baishya ◽  
Tanmay Sarkar ◽  
Hisham Atan Edinur ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Release Rate ◽  
Brain Cancer ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
In Vitro Cytotoxicity ◽  
Loading Efficiency ◽  
Transmission Electron ◽  
Diphenyl Tetrazolium Bromide

Diosgenin encapsulated PCL-Pluronic nanoparticles (PCL-F68-D-NPs) were developed using the nanoprecipitation method to improve performance in brain cancer (glioblastoma) therapy. The nanoparticles were characterized by dynamic light scattering (DLS)/Zeta potential, Fourier-transform infrared (FTIR) spectra, X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and Transmission electron microscopy (TEM). The encapsulation efficiency, loading efficiency, and yield were calculated. The in vitro release rate was determined, and the kinetic model of diosgenin release was plotted and ascertained. The cytotoxicity was checked by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide)assay against U87-MG cells (glioblastoma cell lines). The obtained nanoparticles demonstrated good size distribution, stability, morphology, chemical, and mechanical properties. The nanoparticles also possessed high encapsulation efficiency, loading efficiency, and yield. The release rate of Diosgenin was shown in a sustained manner. The in vitro cytotoxicity of PCL-F68-D-NPs showed higher toxicity against U87-MG cells than free Diosgenin.

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