Interrogation of Solution Conformation of Complex Macrocyclic Peptides Utilizing a Combined SEC-HDX-MS, Circular Dichroism, and NMR Workflow

The Analyst ◽  
2022 ◽  
Author(s):  
Donovon Adpressa ◽  
Mikhail Reibarkh ◽  
Yuan Jiang ◽  
Josep Sauri ◽  
Alexey A. Makarov
Keyword(s):  
Circular Dichroism ◽  
Bound States ◽  
Peptide Conformation ◽  
Solution Conformation ◽  
Macrocyclic Peptides ◽  
Hdx Ms ◽  
Circular Dichroïsm ◽  
Potential Therapeutics

Recent technological and synthetic advances have led to a resurgence in the exploration of peptides as potential therapeutics. Understanding peptide conformation in both free and protein-bound states remains one of...

Enhanced Circular Dichroism and Chiral Sensing with Bound States in the Continuum

2019 ◽  
Author(s):  
Kirill Koshelev ◽  
Yasaman Jahani ◽  
Andreas Tittl ◽  
Hatice Altug ◽  
Yuri Kivshar
Keyword(s):  
Circular Dichroism ◽  
Bound States ◽  
Chiral Sensing ◽  
Circular Dichroïsm ◽  
The Continuum

Determination of the absolute configuration and solution conformation of the antifungal agents ketoconazole, itraconazole, and miconazole with vibrational circular dichroism

Chirality ◽  
2005 ◽  
Vol 17 (S1) ◽  
pp. S101-S108 ◽  
Author(s):  
David Dunmire ◽  
Teresa B. Freedman ◽  
Laurence A. Nafie ◽  
Christine Aeschlimann ◽  
John G. Gerber ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Absolute Configuration ◽  
Antifungal Agents ◽  
Vibrational Circular Dichroism ◽  
Solution Conformation ◽  
The Absolute ◽  
Circular Dichroïsm

Determination of the Atropisomeric Stability and Solution Conformation of Asymmetrically Substituted Biphenyls by Means of Vibrational Circular Dichroism (VCD)

2005 ◽  
Vol 88 (8) ◽  
pp. 2302-2314 ◽  
Author(s):  
Teresa B. Freedman ◽  
Xiaolin Cao ◽  
Laurence A. Nafie ◽  
Monica Kalbermatter ◽  
Anthony Linden ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Vibrational Circular Dichroism ◽  
Solution Conformation ◽  
Circular Dichroïsm

Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism

Chirality ◽  
2003 ◽  
Vol 15 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Teresa B. Freedman ◽  
Xiaolin Cao ◽  
Regina V. Oliveira ◽  
Quezia B. Cass ◽  
Laurence A. Nafie
Keyword(s):  
Circular Dichroism ◽  
Absolute Configuration ◽  
Vibrational Circular Dichroism ◽  
Solution Conformation ◽  
The Absolute ◽  
Circular Dichroïsm
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