The combined effect of Covid-19 and neighbourhood deprivation on two dimensions of subjective well-being: Empirical evidence from England

Objectives The Covid-19 pandemic is hitting societies hard, and people living in disadvantaged circumstances are among the most affected. We investigate the combined effects of the Covid-19 crisis and living in a deprived neighbourhood on two dimensions of subjective well-being: hedonic (i.e. mental health) and evaluative (i.e. life satisfaction) subjective well-being. Methods We use longitudinal data from the Understanding Society UK panel. We combine data gathered in the main survey between 2015 and 2019 with very recent data from the Covid-19 online survey between April and July 2020. Leveraging a sample of nearly 9,600 English individuals, we first run a set of cross-sectional OLS regressions to analyse changes over time in the relationship between neighbourhood deprivation and subjective well-being. Then, as our main model of interest, we use a fixed effect difference-in-differences model to provide more robust evidence. Results Since the beginning of the crisis, both levels of hedonic and evaluative well-being have decreased as a result of the pandemic and lockdown. However, for those living in more deprived neighbourhoods the level of hedonic well-being decreased more than for those living in better areas. We found no such difference for evaluative well-being. Conclusion Our results highlight the importance of reducing neighbourhood inequalities as the spatial clustering of disadvantages has increased by the pandemic.

Feature Design Assessment of the Ship Fire Alarm System

Damages and misfortunes caused by fire on ships have recently accelerated the creation of new approaches, development, and building the security and unchanging quality of the fire detection framework. Simultaneously, with the growing interest in better early fire detection and prevention, numerous frameworks are being created for the detection of progress, with control calculations having the task of carefully preparing and identifying true/false signals from fire or flames or the true alarm from false alarms. By utilizing the assistance provided by innovation, transport owners are more likely to service groups and fleets of ships and reduce potential fire accident costs. This article provides an overview of recent methodologies and technology for early detection of ship fires, as well as an enhanced approach for evaluating the Human-Machine-Interface (HMI) function of an alarming ship using a machine operating simulator called DMS-2017B. The DMS-2017B machinery operation simulator can unify the noise environment to avoid the influence of environmental differences on cabin experimental results. Compared to conventional Binomial Testing, a ship simulator coupled with the theory of affordance that provides a more realistic and operable way to assess the feature design of ship fire alarm and the threshold of some influence factors can also be used. According to the quantitative analysis of experimental results based on the ordered logit model, the function of the ship fire alarm would be improved significantly by adding recorded broadcasting and replacing static symbols with flashing symbols. Increasing sound pressure is also an effective way of doing this, but an auditory threshold is present. Above 75 dB, this effect will fade down, along with noise pollution. However, the effect difference between continuous alarm and square wave pulse alarm is negligible. The conclusion can provide some guidance for the design of a ship fire alarm. An appropriate design is expected to facilitate the efficiency of handling accidents and guiding evacuation.

Publication speed in pharmacy practice journals: A comparative analysis

Background Scholarly publishing system relies on external peer review. However, the duration of publication process is a major concern for authors and funding bodies. Objective To evaluate the duration of the publication process in pharmacy practice journals compared with other biomedical journals indexed in PubMed. Methods All the articles published from 2009 to 2018 by the 33 pharmacy practice journals identified in Mendes et al. study and indexed in PubMed were gathered as study group. A comparison group was created through a random selection of 3000 PubMed PMIDs for each year of study period. Articles with publication dates outside the study period were excluded. Metadata of both groups of articles were imported from PubMed. The duration of editorial process was calculated with three periods: acceptance lag (days between ‘submission date’ and ‘acceptance date’), lead lag (days between ‘acceptance date’ and ‘online publication date’), and indexing lag (days between ‘online publication date’ and ‘Entry date’). Null hypothesis significance tests and effect size measures were used to compare these periods between both groups. Results The 33 pharmacy practice journals published 26,256 articles between 2009 and 2018. Comparison group random selection process resulted in a pool of 23,803 articles published in 5,622 different journals. Acceptance lag was 105 days (IQR 57–173) for pharmacy practice journals and 97 days (IQR 56–155) for the comparison group with a null effect difference (Cohen’s d 0.081). Lead lag was 13 (IQR 6–35) and 23 days (IQR 9–45) for pharmacy practice and comparison journals, respectively, which resulted in a small effect. Indexing lag was 5 days (IQR 2–46) and 4 days (IQR 2–12) for pharmacy practice and control journals, which also resulted in a small effect. Slight positive time trend was found in pharmacy practice acceptance lag, while slight negative trends were found for lead and indexing lags for both groups. Conclusions Publication process duration of pharmacy practice journals is similar to a general random sample of articles from all disciplines.

Efficacy and safety of levilimab in combination with methotrexate in subjects with rheumatoid arthritis: Results of phase II AURORA study

Levilimab (LVL) is a monoclonal antibody against the interleukin-6 receptor (IL6R). The article presents data obtained during 56 weeks of the AURORA phase II study.Objective: to evaluate the efficacy safety and immunogenicity of LVL in methotrexate (MTX) resistant patients with active rheumatoid arthritis (RA).Materials and methods. 105 patients with active RA were randomized in a 1:1:1 ratio into two LVL or placebo groups. LVL was administered subcutaneously at a dose of 162 mg every week (QW) or every other week (Q2W). All patients received MTX. After evaluating the primary endpoint of 20% improvement in ACR criteria (ACR20) at week 12, patients in the placebo group were switched to LVL Q2W. The study duration was 56 weeks. The frequency, profile, degree and severity of adverse events were determined in each group for safety assessment. The immunogenicity of LVL was determined by the proportion of patients with identified binding and neutralizing antidrug antibodies. Results. LVL in both regimens was superior to placebo. At week 12, the incidence of ACR20 achievement was 77.1% (LVL QW), 57.1% (LVL Q2W), and 17.1% (placebo) with 95% confidence intervals [37.53; 82.54] (p<0.0001) and [19.08; 68.42] (p=0.003) for the effect difference between LVL and placebo groups. The clinical response, more pronounced in the LVL QW group, persisted until week 52 with an increase in the proportion of patients with ACR50/70, low activity and RA remission. The most common treatment-related adverse events were laboratory abnormalities (predominantly grade 1–2) such as neutropenia, elevated alanine aminotransferase, aspartate aminotransferase levels, hypercholesterolemia, and elevated triglyceride levels. Antidrug antibodies were not identified.Conclusion. In MTX-resistant patients with active RA, the efficacy of both LVL regimens at a dose of 162 mg in combination with MTX was significantly superior to MT monotherapy. LVL QW lead to highest treatment response. LVL has been shown to be well tolerated and low immunogenicity. LVL safety profile is similar to IL6R inhibitors.

Per-protocol analysis of the ZINC trial for HIV disease among alcohol users

Background The Zinc for INflammation and Chronic disease in HIV (ZINC) trial randomized person who live with HIV (PLWH) who engage in heavy drinking to either daily zinc supplementation or placebo. The primary outcome was change in the Veterans Aging Cohort Study (VACS) index, a predictor of mortality, between baseline and 18 months. Because adherence and follow-up were suboptimal, the intention-to-treat analysis, which was not statistically significant, may have underestimated the effect of the zinc supplementation. Objective We estimated the per-protocol effect of zinc versus placebo in the ZINC trial (i.e., the effect that would have been observed if all participants had had high adherence and none was lost to follow-up). Methods Adherence was measured as the self-reported percentage of pills taken in the previous 6 weeks and assessed at all post-baseline visits. We used inverse probability weighting to estimate and compare the change in the VACS index at 18 months in the zinc and placebo groups, had all the trial participants had high adherence (i.e., cumulative adherence ≥80% at 18 months). To examine trends by level of adherence, we rerun the analyses using thresholds for high adherence of 70% and 90% of average self-reported pill coverage. Results The estimated (95% confidence interval) change in the VACS index was − 2.16 (− 8.07, 3.59) and 5.84 (0.73, 11.80) under high adherence and no loss to follow-up in the zinc and placebo groups, respectively. The per-protocol effect estimate of the mean difference in the change between the zinc and placebo groups was − 8.01 (− 16.42, 0.01), somewhat larger than the intention-to-treat effect difference in change (− 4.68 (− 9.62, 0.25)), but it was still not statistically significant. The mean difference in the change between individuals in the zinc and placebo groups was − 4.07 (− 11.5, 2.75) and −12.34 (− 20.14, −4.14) for high adherence defined as 70% and 90% of pill coverage, respectively. Conclusions Overall, high adherence to zinc was associated with a lower VACS score, but confidence intervals were wide and crossed 0. Further studies with a larger sample size are needed to quantify the benefits of zinc supplementation in this population. Trial registration ClinicalTrials.gov NCT01934803. Registered on August 30, 2013

The Impact of the Livestock Friendly Designation on the Nebraska Cattle Industry: A Difference-in-Difference with Staggered Treatment Analysis

In 2003, the Nebraska Legislature enacted the Livestock Friendly County designation program to promote the livestock industry in the state. Forty-nine of the state’s 93 counties received the designation at staggered years. Our paper estimates the causal effect of the program on the state’s cattle industry using a fixed effect difference-in-difference model that accounts for self-selection and staggered designation. Results indicate that the program does not appear to have a statewide effect on livestock expansion, but it is effective in some crop reporting districts. We offer some hypotheses on why this may be the case and draw some policy implications.

Pegaruh Penambahan Sari Wortel Terhadap Pembuatan Yogurt ditinjau dari fisik kimia dan organoleptik

Yoghurt was one form of beverage products from milk processing that utilizes microbes in the fermentation of fresh milk into a semi-solid emulsion product with a more acidic taste. The aim of this research was to know the effect of carrot juice and optimal addition were: color, organoleptic quality (aroma, texture, color and taste), vitamin C, WHC of yoghurt. The materials used were fresh milk, carrot juice, starter plain yoghurt. The method used in this research is experimental method with Randomized Completely Block Design of 5 treatments namely the addition of carrot juice in yoghurt with concentration 0%, 10%, 15%, 20%, and 25% of milk volume (1000 ml), with each treatment was done with 4 blocks. The data analysis used variance analysis, followed by Duncan Multiple Range Test. The results showed that the addition of carrot juice 20% in the manufacture of yoghurt with different concentrations gave a very significant effect difference (P<0.01) on the lightness (L*), yellowness (b*), vitamin C and WHC as well as a real effect (P <0,05) to the redness color (a*) and not not give significant effect (P>0,05) to pH, syneresis and lactic acid bacteria. The result showed that the concentration of adding carrot juice is 20%, which results in the best quality yogurt drink with the following average values of vitamin C; 15.13%, color; 59.95 (L), 19.30 (a *), 25.85 (b *), WHC; 25% and organoleptic; 3.75 (aroma), 3.98 (color), 3.40 (taste) 4.44 (texture), pH; 4.75Keyword: carrot juice, physical quality, yoghurt

Restaurant proactive philanthropic activities and customer loyalty: a scenario-based study during the COVID-19 pandemic period

PurposeThis study aims to (1) examine the effect of customer awareness of restaurant philanthropic activities on customer loyalty; (2) investigate the mediating roles of customer social benevolence trust, perceived restaurant reputation and affective commitment on the relationship between their awareness of restaurant philanthropic activities and customer loyalty; and (3) test the path effect differences between the directed and general philanthropic activities during the COVID-19 pandemic period.Design/methodology/approachThis study used online scenario-based surveys to collect data. Based on 293 useable surveys, partial least squares structural equation modeling was applied for data analysis.FindingsThis study finds that customer awareness of restaurant philanthropic activities positively relates to customer loyalty. Moreover, customer social benevolence trust, perceived restaurant reputation and affective commitment have positive mediating effects on the relationship between their awareness of restaurant philanthropic activities and customer loyalty. There is no significant path effect difference between the directed and general philanthropic activities.Practical implicationsThis study suggests that restaurant decision-makers should conduct either directed or general philanthropic activities as a marketing tool to sustain customers during the COVID-19 recovery.Originality/valueThis study is the first study that discusses the marketing role of corporate philanthropy in the restaurant industry during the COVID-19 pandemic and stresses the importance of proactive strategic donations that helps restaurants' recovery.