Multinuclear mesoionic 1,2,3-triazolylidene complexes: Design, synthesis, and applications

2022 ◽  
Author(s):  
Emmanuel Blas Patricio-Rangel ◽  
Verónica Salazar ◽  
Omar Cortezano-Arellano ◽  
Daniel Mendoza-Espinosa
Keyword(s):  
Metal Complexes ◽  
Organometallic Chemistry ◽  
Design Synthesis ◽  
Fast Growing

The chemistry of multinuclear metal complexes bearing by N-heterocyclic carbene (NHC) ligands, is an area of fast growing interest in modern organometallic chemistry. In particular, complexes supported by mesoionic (MIC)...

N-heterocyclic carbene-metal complexes as bio-organometallic antimicrobial and anticancer drugs, an update (2015–2020)

2020 ◽  
Vol 12 (24) ◽  
pp. 2239-2275
Author(s):  
Siddappa A Patil ◽  
Amy P Hoagland ◽  
Shivaputra A Patil ◽  
Alejandro Bugarin
Keyword(s):  
Metal Complexes ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Therapeutic Agents ◽  
Heterocyclic Carbenes ◽  
Design Synthesis ◽  
Drug Candidates ◽  
The Past ◽  
Simple Variation ◽  
Future Work

N-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical properties of phosphines. NHCs have made a significant impact on the field of coordination and organometallic chemistry because they are easy to prepare and handle and because of their versatility and stability. Importantly, the physicochemical properties of NHCs can be easily fine-tuned by simple variation of substituents on the nitrogen atoms. Over the past few years, various NHC–metal complexes have been extensively used as metal-based drug candidates and catalysts (homogeneous or heterogeneous) for various applications. To help assist future work with these compounds, this review provides a thorough review on the latest information involving some biomedical applications of NHC–metal complexes. Specifically, this article focuses on recent advances in the design, synthesis, characterization and biomedical applications (e.g., antimicrobial and anticancer activity) of various NHC–metal complexes (metal: silver, gold, palladium, rhodium, ruthenium, iridium and platinum) covering work published from 2015 to 2020. It is hoped that the promising discoveries to date will help accelerate studies on the encouraging potential of NHC–metal complexes as a class of effective therapeutic agents.

Association of late transition metal complexes with ethyl 2-(2-(4-chlorophenylcarbamothioyl)hydrazono)propanoate: Design, synthesis and in vitro anticancer studies

2015 ◽  
Vol 430 ◽  
pp. 216-224 ◽  
Author(s):  
Aishakhanam H. Pathan ◽  
Asha K. Ramesh ◽  
Raghavendra P. Bakale ◽  
Ganesh N. Naik ◽  
H.G. Rohit Kumar ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Late Transition Metal ◽  
Design Synthesis ◽  
Late Transition
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