Development of 2-deoxystreptamine-nucleobase conjugates for the inhibition of oncogenic miRNAs production

2022 ◽  
Author(s):  
Thi Phuong Anh Tran ◽  
Sylvain Poulet ◽  
Mélanie Pernak ◽  
Anita Rayar ◽  
Stephane Azoulay ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Rna Targeting ◽  
Oncogenic Mirnas

The discovery of new original scaffolds for selective RNA targeting is one of the main challenges of current medicinal chemistry since therapeutically relevant RNAs represent potential targets for a number...

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
A Henrici ◽  
R Montalbano ◽  
K Quint ◽  
M Ocker ◽  
P Di Fazio
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Down Regulation ◽  
Liver Cancer Cells ◽  
Oncogenic Mirnas

An Advance In Medicinal Chemistry

1952 ◽  
Vol 8 (5) ◽  
pp. 81-84
Author(s):  
Howard A. Sumner
Keyword(s):  
Medicinal Chemistry

SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates and Sulfonamides from S(VI) Fluorides

2020 ◽  
Author(s):  
Subham Mahapatra ◽  
Cristian P. Woroch ◽  
Todd W. Butler ◽  
Sabrina N. Carneiro ◽  
Sabrina C. Kwan ◽  
...  
Keyword(s):  
Room Temperature ◽  
Medicinal Chemistry ◽  
Mild Conditions ◽  
Broad Array

<p><br></p> <p>A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide, and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight the application of this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds. </p>

Sign in / Sign up

Export Citation Format

Share Document