One-pot Synthesis of 3-Substituted-3-Hydroxyindolin-2-ones: Three Component Coupling of N-Protected isatin, Aryne Precursor and 1, 3-Cyclodione under Metal-free Conditions

2021 ◽  
Author(s):  
Hemanta Hazarika ◽  
Babulal Das ◽  
Kangkana Chutia ◽  
Pranjal Gogoi
Keyword(s):  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Three Components ◽  
Three Component Coupling

An aryne-based synthetic protocol has been developed for the synthesis of 3-substituted-3-hydroxy-indolin-2-ones. A wide variety of 3-hydroxyindolin-2-ones were synthetized in good yields under metal-free conditions via three components coupling of...

One-Pot Synthesis of α-Halo β-Amino Acid Derivatives via the Difunctional Coupling of Ethyl α-Diazoacetate with Silyl Halides and N,O-Acetals or Aromatic Tertiary Amines

Synthesis ◽  
2020 ◽  
Vol 52 (12) ◽  
pp. 1823-1832 ◽  
Author(s):  
Norio Sakai ◽  
Kazuki Sasaki ◽  
Hiroki Suzuki ◽  
Yohei Ogiwara
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Amino Acid Esters ◽  
Tertiary Amines ◽  
One Pot ◽  
Metal Free ◽  
Reaction Intermediate ◽  
One Pot Synthesis ◽  
Acid Esters ◽  
Three Component Coupling

The difunctionalization of ethyl α-diazoacetate (EDA) using silyl halides as a nucleophile and N,O-acetals as an electrophile under metal-free conditions is described. This process undergoes a novel three-component coupling (3-CC) reaction using EDA, which leads to a one-pot preparation of α-halo β-amino acid esters. Also, this protocol could be adapted to accept an electrophile composed of aromatic tertiary amines. In both 3-CC reactions, the key reaction intermediate is an iminium intermediate that can be easily and effectively generated either from N,O-acetals or from aromatic tertiary amines.

One-pot synthesis of bio-based polycarbonates from dimethyl carbonate and isosorbide under metal-free condition

2020 ◽  
Vol 22 (14) ◽  
pp. 4550-4560
Author(s):  
Wenjuan Fang ◽  
Zhencai Zhang ◽  
Zifeng Yang ◽  
Yaqin Zhang ◽  
Fei Xu ◽  
...  
Keyword(s):  
Dimethyl Carbonate ◽  
One Pot ◽  
Free Condition ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Synthetic Strategy

A synthetic strategy for bio-based polycarbonate was developed via one-pot polymerization of renewable monomer isosorbide and dimethyl carbonate using eco-friendly organo-catalysts.

ChemInform Abstract: I2Promoted Domino Oxidative Cyclization for One-Pot Synthesis of 2-Acylbenzothiazoles via Metal-Free sp3C-H Functionalization.

ChemInform ◽  
2012 ◽  
Vol 43 (52) ◽  
pp. no-no
Author(s):  
Yan-Ping Zhu ◽  
Mi Lian ◽  
Feng-Cheng Jia ◽  
Mei-Cai Liu ◽  
Jing-Jing Yuan ◽  
...  
Keyword(s):  
Oxidative Cyclization ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

ChemInform Abstract: Transition Metal Free Intramolecular S-Arylation: One-Pot Synthesis of Thiochromen-4-ones.

ChemInform ◽  
2014 ◽  
Vol 45 (13) ◽  
pp. no-no
Author(s):  
T. A. Jenifer Vijay ◽  
Kebbahalli N. Nandeesh ◽  
Goravanahalli M. Raghavendra ◽  
Kanchugarakoppal S. Rangappa ◽  
Kempegowda Mantelingu
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

scholarly journals Brønsted acid-catalyzed metal-free one-pot synthesis of benzimidazoles via [4+1] heteroannulation of ortho-phenylenediamines with β-oxodithioesters

ARKIVOC ◽  
2017 ◽  
Vol 2018 (2) ◽  
pp. 81-89
Author(s):  
Abhijeet Srivastava ◽  
Gaurav Shukla ◽  
Dhananjay Yadav ◽  
Maya Shankar Singh
Keyword(s):  
Bronsted Acid ◽  
Brønsted Acid ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Brönsted Acid ◽  
Acid Catalyzed

ChemInform Abstract: Three-Component Coupling of Acylphosphonates and Two Carbonyl Compounds Promoted by Low-Valent Samariums: One-Pot Synthesis of β-Hydroxyphosphonates.

ChemInform ◽  
2010 ◽  
Vol 31 (18) ◽  
pp. no-no
Author(s):  
Ken Takaki ◽  
Yuichiro Itono ◽  
Akihiro Nagafuji ◽  
Yoji Naito ◽  
Tetsuya Shishido ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
One Pot ◽  
One Pot Synthesis ◽  
Low Valent ◽  
Three Component Coupling

One-pot synthesis of thioesters with sodium thiosulfate as a sulfur surrogate under transition metal-free conditions

2018 ◽  
Vol 16 (11) ◽  
pp. 1871-1881 ◽  
Author(s):  
Yen-Sen Liao ◽  
Chien-Fu Liang
Keyword(s):  
Transition Metal ◽  
Sodium Thiosulfate ◽  
Sulfur Source ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

We have developed a one-pot reaction to provide thioester derivativesviasodium thiosulfate as a sulfur source under transition metal-free conditions.

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