Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a sulfonyl moiety as potent dual inhibitors of PLK1 and BRD4

2021 ◽  
Author(s):  
Fei Chen ◽  
Yu Wang ◽  
Zhanfeng Gao ◽  
Shihui Wang ◽  
Jiuyu Liu ◽  
...  
Keyword(s):  
Single Molecule ◽  
Therapeutic Strategy ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Effective Therapeutic Strategy ◽  
Dual Inhibitors ◽  
Simultaneous Inhibition ◽  
Synthesis And Biological Evaluation

The simultaneous inhibition of PLK1 and BRD4 by a single molecule could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and...

Design, synthesis and biological evaluation of novel pteridinone derivatives as potent dual inhibitors of PLK1 and BRD4

2020 ◽  
Vol 44 (38) ◽  
pp. 16477-16490
Author(s):  
Yinliang Qi ◽  
Le Xu ◽  
Zhiwei Li ◽  
Ping Gong ◽  
Tao Hu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Single Molecule ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Simultaneous Inhibition ◽  
Synthesis And Biological Evaluation

To develop novel simultaneous inhibition of PLK1 and BRD4 bromodomain by a single molecule, three series of novel pteridinone derivatives were designed, synthesized and evaluated for their biological activity.

scholarly journals Design, Synthesis and Biological Evaluation of Novel Phenylsulfonylurea Derivatives as PI3K/mTOR Dual Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1553
Author(s):  
Bingbing Zhao ◽  
Fei Lei ◽  
Caolin Wang ◽  
Binliang Zhang ◽  
Zunhua Yang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Correction: Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 4927-4927
Author(s):  
Vegard Torp Lien ◽  
Margrethe Konstanse Kristiansen ◽  
Solveig Pettersen ◽  
Mads Haugland Haugen ◽  
Stefan Krauss ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation

Correction for ‘Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation’ by Vegard Torp Lien et al., RSC Adv., 2019, 9, 37092–37100.

Sign in / Sign up

Export Citation Format

Share Document