Cyanomethylative cyclization of unactivated alkenes with nitriles for the synthesis of cyano-containing ring-fused quinazolin-4(3H)-ones

2022 ◽  
Author(s):  
Han Liu ◽  
Zixian Yang ◽  
Gao Huang ◽  
Jin-Tao Yu ◽  
Changduo Pan
Keyword(s):  
Radical Addition ◽  
Metal Free

The synthesis of cyano-containing ring-fused quinazolin-4(3H)-one derivatives was developed under metal-free conditions. This reaction undergoes radical C(sp3)-H functionalization of alkyl nitriles, cascade radical addition/cyclization with N-alkylated quinazolinones to deliver the...

K2S2O8-mediated metal-free direct P–H/C–H functionalization: a convenient route to benzo[b]phosphole oxides from unactivated alkynes

2016 ◽  
Vol 18 (12) ◽  
pp. 3522-3526 ◽  
Author(s):  
Dumei Ma ◽  
Weizhu Chen ◽  
Gaobo Hu ◽  
Yun Zhang ◽  
Yuxing Gao ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Metal Contamination ◽  
Heavy Metal Contamination ◽  
Radical Addition ◽  
Metal Free ◽  
Internal Alkynes ◽  
Convenient Route

A metal-free and K2S2O8-mediated radical addition/cyclization of internal alkynes leading to benzo[b]phosphole oxides was developed, which eliminates residual heavy metal contamination in the product.

N-Chloroamines as substrates for metal-free photochemical atom-transfer radical addition reactions in continuous flow

2021 ◽  
Author(s):  
Alexander Steiner ◽  
Oscar de Frutos ◽  
Juan A. Rincón ◽  
Carlos Mateos ◽  
Jason Williams ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Radical Addition ◽  
Addition Reactions ◽  
Atom Transfer ◽  
Metal Free ◽  
Atom Transfer Radical Addition

N-Chloroamines have recently seen interest as substrates for atom-transfer radical addition (ATRA) reactions with olefins, to form β-chloroamine products, with complete atom incorporation. We report the development of a fully...

Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature

2019 ◽  
Vol 6 (13) ◽  
pp. 2245-2249 ◽  
Author(s):  
Guibing Wu ◽  
Jingwen Wang ◽  
Chengyu Liu ◽  
Maolin Sun ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Carboxylic Acids ◽  
Room Temperature ◽  
Radical Addition ◽  
Metal Free ◽  
Radical Coupling

A metal-free photoredox catalyzed decarboxylative radical coupling of free-carboxylic acids and glyoxylic oximes was developed to synthesize α,β-diamino acids.

ChemInform Abstract: A Metal-Free Synthesis of Oxindoles by a Radical Addition-Cyclization onto N-Arylacrylamides with Xanthates.

ChemInform ◽  
2015 ◽  
Vol 46 (28) ◽  
pp. no-no
Author(s):  
Shucheng Wang ◽  
Xuhu Huang ◽  
Bowen Li ◽  
Zemei Ge ◽  
Xin Wang ◽  
...  
Keyword(s):  
Radical Addition ◽  
Metal Free

Metal-free synthesis of ketones by visible-light induced aerobic oxidative radical addition of aryl hydrazines to alkenes

2017 ◽  
Vol 19 (13) ◽  
pp. 2941-2944 ◽  
Author(s):  
Ya Ding ◽  
Wenkai Zhang ◽  
Hao Li ◽  
Yunge Meng ◽  
Te Zhang ◽  
...  
Keyword(s):  
Visible Light ◽  
Cost Effective ◽  
Radical Addition ◽  
Metal Free ◽  
Cost Effective Method

A green and cost-effective method has been developed for the conversion of alkenes to ketones under metal-free conditions.

A metal-free synthesis of oxindoles by a radical addition-cyclization onto N-arylacrylamides with xanthates

Tetrahedron ◽  
2015 ◽  
Vol 71 (12) ◽  
pp. 1869-1875 ◽  
Author(s):  
Shucheng Wang ◽  
Xuhu Huang ◽  
Bowen Li ◽  
Zemei Ge ◽  
Xin Wang ◽  
...  
Keyword(s):  
Radical Addition ◽  
Metal Free

Catalytic, metal-free sulfonylcyanation of alkenes via visible light organophotoredox catalysis

2018 ◽  
Vol 54 (25) ◽  
pp. 3162-3165 ◽  
Author(s):  
Jianfeng Sun ◽  
Peng Li ◽  
Lei Guo ◽  
Fang Yu ◽  
Yu-Peng He ◽  
...  
Keyword(s):  
Visible Light ◽  
Radical Addition ◽  
Neutral Group ◽  
Group Transfer ◽  
Metal Free ◽  
Catalytic Metal

A catalytic, redox-neutral group transfer radical addition of olefins with tosyl cyanide via visible light-induced organophotoredox catalysis has been described.

Metal‐free Photochemical Atom Transfer Radical Addition (ATRA) of BrCCl 3 to Alkenes

2020 ◽  
Vol 2021 (1) ◽  
pp. 96-101
Author(s):  
Nikolaos F. Nikitas ◽  
Errika Voutyritsa ◽  
Petros L. Gkizis ◽  
Christoforos G. Kokotos
Keyword(s):  
Radical Addition ◽  
Atom Transfer ◽  
Metal Free ◽  
Atom Transfer Radical Addition
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