2D/2D Bi2WO6/Protonated g-C3N4 Step-scheme Heterojunctions for Enhancing Photodegradation of 17β-Estradiol: Promotional Role of Electrostatic Interaction

2022 ◽  
Author(s):  
Yashi Qing ◽  
Yanxiang Li ◽  
Dan Hu ◽  
Zhiwei Guo ◽  
Yujie Yang ◽  
...  
Keyword(s):  
Human Health ◽  
Electrostatic Interaction ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
17Β Estradiol

17β-Estradiol (E2) is a type of endocrine disrupting chemicals (EDCs) with the strongest estrogenic activity which poses a huge threat to the ecosystems and human health even at extremely low...

scholarly journals Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

2020 ◽  
Vol 17 (16) ◽  
pp. 5664 ◽  
Author(s):  
Chao Zhang ◽  
Tiziana Schilirò ◽  
Marta Gea ◽  
Silvia Bianchi ◽  
Angelo Spinello ◽  
...  
Keyword(s):  
Competitive Inhibition ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Binding Mode ◽  
Inhibition Mechanism ◽  
Aromatase Activity ◽  
Docking Simulations ◽  
Potential Binding ◽  
Endocrine Disrupting ◽  
17Β Estradiol

The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradiol, thiacloprid and imidacloprid induced an estrogenic activity at the highest concentrations tested with a relative potency of 5.4 × 10−10 and 3.7 × 10−9, respectively. Molecular dynamics and docking simulations predicted the potential binding sites and the binding mode of the three pesticides on the structure of the two key targets, providing a rational for their mechanism as EDCs. The results demonstrate that the three pesticides are potential EDCs as glyphosate acts as an aromatase inhibitor, whereas imidacloprid and thiacloprid can interfere with estrogen induced signaling.

scholarly journals The Role of Metabolism in the Estrogenic Activity of Endocrine-Disrupting Chemicals

Estrogen ◽  
2019 ◽  
Author(s):  
Darja Gramec Skledar ◽  
Lucija Peterlin Mašič
Keyword(s):  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

scholarly journals The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case?control study in rural Sicily

2007 ◽  
Vol 30 (1) ◽  
pp. 3-13 ◽  
Author(s):  
P. Carbone ◽  
F. Giordano ◽  
F. Nori ◽  
A. Mantovani ◽  
D. Taruscio ◽  
...  
Keyword(s):  
Case Control Study ◽  
Endocrine Disrupting Chemicals ◽  
Population Based ◽  
Case Control ◽  
Endocrine Disrupting ◽  
Control Study

Endocrine disrupting chemicals in wild freshwater fishes: Species, tissues, sizes and human health risks

2019 ◽  
Vol 244 ◽  
pp. 462-468 ◽  
Author(s):  
Xinyi Zhou ◽  
Zhaoguang Yang ◽  
Zhoufei Luo ◽  
Haipu Li ◽  
Guoyao Chen
Keyword(s):  
Human Health ◽  
Health Risks ◽  
Endocrine Disrupting Chemicals ◽  
Freshwater Fishes ◽  
Human Health Risks ◽  
Endocrine Disrupting

In vitro estrogenic activity of representative endocrine disrupting chemicals mixtures at environmentally relevant concentrations

Chemosphere ◽  
2019 ◽  
Vol 215 ◽  
pp. 396-403 ◽  
Author(s):  
Hui Yu ◽  
Daniel J. Caldwell ◽  
Rominder P. Suri
Keyword(s):  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

scholarly journals Epidemiological Approaches to the Effects of Endocrine Disrupting Chemicals on Human Health

2000 ◽  
Vol 21 (6) ◽  
pp. 361-367 ◽  
Author(s):  
MASAHARU YAMAMOTO ◽  
HIROTO NAKADAIRA ◽  
KAZUTOSHI NAKAMURA ◽  
KAZUO ENDOH
Keyword(s):  
Human Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

Assessing Estrogenic Activities of Selected Endocrine Disrupting Chemicals and their Combination Effects

2013 ◽  
Vol 765-767 ◽  
pp. 2944-2948 ◽  
Author(s):  
Xiao Ling Shao ◽  
Wen Qi Zhong ◽  
Xiao Yan Ma ◽  
Ang Gao ◽  
Xiang Yang Wu ◽  
...  
Keyword(s):  
Binary Systems ◽  
Endocrine Disrupting Chemicals ◽  
Concentration Addition ◽  
Multicomponent Mixtures ◽  
Yeast Two Hybrid ◽  
Yeast Two Hybrid System ◽  
Endocrine Disrupting ◽  
17Β Estradiol ◽  
Ethylhexyl Phthalate ◽  
Two Hybrid

Yeast two-hybrid system was used to investigate the estrogenic activities of 13 kinds of representative endocrine disrupting chemicals (EDCs) and their combinary effects. Results show that the order of estrogenic potencies for these chemicals is: 17α-ethynylestradiol>diethylstilbestrol >17β-estradiol>estrone>estriol>branchedp-nonylphenol>4-t-octylphenol>bisphenol A>diethyl phthalate>4-n-nonylphenol>di-(2-ethylhexyl) phthalate>dibutyl phthalate>dimethyl phthalate. The mixture effects of multiple EDCs were compared to those obtained from individual chemicals, using the model of concentration addition. Results reveal that the estrogenicities of multicomponent mixtures of more than three (including three) of EDCs follow antagonistic effects, while there is no definite conclusion for binary systems. The less than additive effects were also confirmed in the spiked experiments conducted in the extracts of real water samples.

scholarly journals Hypothetical roadmap towards endometriosis: prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota and subclinical infections

2020 ◽  
Vol 26 (2) ◽  
pp. 214-246 ◽  
Author(s):  
Pilar García-Peñarrubia ◽  
Antonio J Ruiz-Alcaraz ◽  
María Martínez-Esparza ◽  
Pilar Marín ◽  
Francisco Machado-Linde
Keyword(s):  
Prenatal Exposure ◽  
Genital Tract ◽  
Endocrine Disrupting Chemicals ◽  
Active Role ◽  
Faecal Microbiota ◽  
Clinical Progression ◽  
Anogenital Distance ◽  
Endocrine Disrupting ◽  
Microbial Infections

Abstract BACKGROUND Endometriosis is a gynaecological hormone-dependent disorder that is defined by histological lesions generated by the growth of endometrial-like tissue out of the uterus cavity, most commonly engrafted within the peritoneal cavity, although these lesions can also be located in distant organs. Endometriosis affects ~10% of women of reproductive age, frequently producing severe and, sometimes, incapacitating symptoms, including chronic pelvic pain, dysmenorrhea and dyspareunia, among others. Furthermore, endometriosis causes infertility in ~30% of affected women. Despite intense research on the mechanisms involved in the initial development and later progression of endometriosis, many questions remain unanswered and its aetiology remains unknown. Recent studies have demonstrated the critical role played by the relationship between the microbiome and mucosal immunology in preventing sexually transmitted diseases (HIV), infertility and several gynaecologic diseases. OBJECTIVE AND RATIONALE In this review, we sought to respond to the main research question related to the aetiology of endometriosis. We provide a model pointing out several risk factors that could explain the development of endometriosis. The hypothesis arises from bringing together current findings from large distinct areas, linking high prenatal exposure to environmental endocrine-disrupting chemicals with a short anogenital distance, female genital tract contamination with the faecal microbiota and the active role of genital subclinical microbial infections in the development and clinical progression of endometriosis. SEARCH METHODS We performed a search of the scientific literature published until 2019 in the PubMed database. The search strategy included the following keywords in various combinations: endometriosis, anogenital distance, chemical pollutants, endocrine-disrupting chemicals, prenatal exposure to endocrine-disrupting chemicals, the microbiome of the female reproductive tract, microbiota and genital tract, bacterial vaginosis, endometritis, oestrogens and microbiota and microbiota–immune system interactions. OUTCOMES On searching the corresponding bibliography, we found frequent associations between environmental endocrine-disrupting chemicals and endometriosis risk. Likewise, recent evidence and hypotheses have suggested the active role of genital subclinical microbial infections in the development and clinical progression of endometriosis. Hence, we can envisage a direct relationship between higher prenatal exposure to oestrogens or estrogenic endocrine-disrupting compounds (phthalates, bisphenols, organochlorine pesticides and others) and a shorter anogenital distance, which could favour frequent postnatal episodes of faecal microbiota contamination of the vulva and vagina, producing cervicovaginal microbiota dysbiosis. This relationship would disrupt local antimicrobial defences, subverting the homeostasis state and inducing a subclinical inflammatory response that could evolve into a sustained immune dysregulation, closing the vicious cycle responsible for the development of endometriosis. WIDER IMPLICATIONS Determining the aetiology of endometriosis is a challenging issue. Posing a new hypothesis on this subject provides the initial tool necessary to design future experimental, clinical and epidemiological research that could allow for a better understanding of the origin of this disease. Furthermore, advances in the understanding of its aetiology would allow the identification of new therapeutics and preventive actions.

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