MXene, a class of 2D transition metal carbide/nitride materials, has attracted widespread attention since its first discovery in 2011. Due to its high electronic conductivity, large specific surface area, good mechanical stability, and adjustable surface functional groups, MXene-based nanomaterials have shown great potential in energy storage devices. Meanwhile, zinc-based aqueous energy storage devices became a hotspot recently in energy storage field on account of their high security and low cost. In this review, the research progress on the preparation routes, preserving method, related structure and properties of MXene is first summarized. Followed by is an introduction of the recent state-of-the-art development of MXene-based electrodes for zinc-based aqueous energy storage devices, including zinc ion batteries (ZIBs), zinc-air batteries (ZABs), and zinc-halide batteries (ZHBs). Finally, the major bottleneck and perspectives for MXene-based nanomaterials in zinc-based aqueous energy storage devices are pointed out.