scholarly journals Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases

Nanoscale ◽  
2021 ◽  
Author(s):  
Xinyue Chen ◽  
Russell Hughes ◽  
Nic Mullin ◽  
Rhoda J Hawkins ◽  
Ingunn Holen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Atomic Force Microscopy ◽  
Mechanical Characterization ◽  
Metastatic Cancer ◽  
Force Microscopy ◽  
Atomic Force ◽  
Cancer Metastases ◽  
Intact Sample ◽  
Dependent Processes

Mechanically dependent processes are essential in cancer metastases. However, reliable mechanical characterization of metastatic cancer remains challenging whilst maintaining the tissue complexity and an intact sample. Using atomic force microscopy,...

scholarly journals Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases

2021 ◽  
Author(s):  
Xinyue Chen ◽  
Russell Hughes ◽  
Nic Mullin ◽  
Rhoda J Hawkins ◽  
Ingunn Holen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
Metastatic Cancer ◽  
Metastatic Breast ◽  
Metastatic Tumour ◽  
Force Microscopy ◽  
Atomic Force ◽  
Cancer Metastases

Mechanically dependent processes are essential in cancer metastases. However, reliable mechanical characterisation of metastatic cancer remains challenging whilst maintaining the tissue complexity and an intact sample. Using atomic force microscopy, we quantified the micro-mechanical properties of relatively intact metastatic breast tumours and their surrounding bone microenvironment isolated from mice, and compared with other breast cancer models both ex vivo and in vitro. A unique mechanical distribution of extremely low elastic modulus and viscosity was identified on metastatic tumours, which were significantly more compliant than both 2D in vitro cultured cancer cells and subcutaneous tumour explants. The presence of mechanically distinct metastatic tumour did not result in alterations of the mechanical properties of the surrounding microenvironment at meso-scale distances (> 200 μm). These findings demonstrate the utility of atomic force microscopy in studies of complex tissues and provide new insights into the mechanical properties of cancer metastases in bone.

scholarly journals Mechanical Characterization of Microengineered Epithelial Cysts by Using Atomic Force Microscopy

2017 ◽  
Vol 112 (2) ◽  
pp. 398-409 ◽  
Author(s):  
Yusheng Shen ◽  
Dongshi Guan ◽  
Daniela Serien ◽  
Shoji Takeuchi ◽  
Penger Tong ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Mechanical Characterization ◽  
Force Microscopy ◽  
Atomic Force ◽  
Epithelial Cysts

Mechanical characterization of polymeric thin films by atomic force microscopy based techniques

2012 ◽  
Vol 405 (5) ◽  
pp. 1463-1478 ◽  
Author(s):  
Daniele Passeri ◽  
Marco Rossi ◽  
Emanuela Tamburri ◽  
Maria Letizia Terranova
Keyword(s):  
Thin Films ◽  
Atomic Force Microscopy ◽  
Mechanical Characterization ◽  
Polymeric Thin Films ◽  
Force Microscopy ◽  
Atomic Force
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