scholarly journals Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions

RSC Advances ◽  
2021 ◽  
Vol 11 (39) ◽  
pp. 24466-24473
Author(s):  
Reagan L. Mohlala ◽  
E. Mabel Coyanis ◽  
Manuel A. Fernandes ◽  
Moira L. Bode
Keyword(s):  
Benzimidazole Derivatives ◽  
One Pot ◽  
Catalyst Free ◽  
Benzodiazepine Derivatives

Reaction of benzimidazole derivatives with an isocyanide and acetone led to tricyclic benzodiazepine derivatives or dihydroquinoxalines depending on the nature of the substituents R1 and R2.

Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex

2020 ◽  
Author(s):  
José Tiago Menezes Correia ◽  
Gustavo Piva da Silva ◽  
Camila Menezes Kisukuri ◽  
Elias André ◽  
Bruno Pires ◽  
...  
Keyword(s):  
Electron Donor ◽  
Functional Group ◽  
Photoexcited Electron ◽  
One Pot ◽  
Quaternary Centers ◽  
Metal Free ◽  
Acceptor Complex ◽  
Catalyst Free ◽  
Donor Acceptor ◽  
Radical Cascade

A metal- and catalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a SET event involving a photoexcited electron-donor-aceptor complex between NHPI ester and Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne. <a>The method provides an operationally simple, robust and step-economical approach to the construction of diversely functionalized dihydroquinolinones bearing quaternary-centers. A sequential one-pot hydroalkylation-isomerization approach is also allowed giving access to a family of quinolinones. A wide substrate scope and high functional group tolerance was observed in both approaches</a>.

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Biological Screening ◽  
Elemental Analyses ◽  
Characterization Studies

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Catalyst-free synthesis of phenanthridines via electrochemical coupling of 2-isocyanobiphenyls and amines

2021 ◽  
Vol 45 (14) ◽  
pp. 6367-6378
Author(s):  
Bhanwar Kumar Malviya ◽  
Karandeep Singh ◽  
Pradeep K. Jaiswal ◽  
Manvika Karnatak ◽  
Ved Prakash Verma ◽  
...  
Keyword(s):  
One Pot ◽  
Metal Free ◽  
Catalyst Free ◽  
Electrochemical Coupling

One pot metal-free synthesis of phenanthridines and amides under electrochemical conditions.

Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes

2021 ◽  
Author(s):  
Xing Li ◽  
Pingan Zhai ◽  
Yongsheng Fang ◽  
Wenhui Li ◽  
Honghong Chang ◽  
...  
Keyword(s):  
One Pot ◽  
Catalyst Free ◽  
Practical Strategy ◽  
Three Component Reaction

A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described.

Efficient construction of 5H‐1,4‐benzodiazepine derivatives by a catalyst‐free direct aerobic oxidative annulation strategy

ChemSusChem ◽  
2021 ◽  
Author(s):  
Qing Xu ◽  
Qi Wang ◽  
Xiaolan Zhang ◽  
Feng Han ◽  
Jianping Liu
Keyword(s):  
Catalyst Free ◽  
Efficient Construction ◽  
Benzodiazepine Derivatives

One-pot, catalyst-free synthesis of novel dihydropyrano[2,3-e]indole derivatives

2021 ◽  
Vol 33 ◽  
pp. 100693
Author(s):  
Visarapu Malathi ◽  
Shantholla Shivani ◽  
K Bhaskar ◽  
Vinod G. Ugale ◽  
Pannala Padmaja ◽  
...  
Keyword(s):  
Indole Derivatives ◽  
One Pot ◽  
Catalyst Free

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

Organocatalyzed One-Pot Synthesis of Substituted 1,5-Benzodiazepine and Benzimidazole Derivatives

2010 ◽  
Vol 40 (11) ◽  
pp. 1685-1693 ◽  
Author(s):  
Papori Goswami ◽  
Babulal Das
Keyword(s):  
Benzimidazole Derivatives ◽  
One Pot ◽  
One Pot Synthesis

ChemInform Abstract: The Thiocarbonyl “S” Is Softer than Thiolate “S”: A Catalyst-Free One-Pot Synthesis of Isothiocyanates in Water.

ChemInform ◽  
2010 ◽  
Vol 41 (32) ◽  
pp. no-no
Author(s):  
Latonglila Jamir ◽  
Abdur Rezzak Ali ◽  
Harisadhan Ghosh ◽  
Francis A. S. Chipem ◽  
Bhisma K. Patel
Keyword(s):  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis
Sign in / Sign up

Export Citation Format

Share Document