Naphthalene-facilitated self-assembly of Gd-chelate as a novel T2 MRI contrast agent for visualization of stem cell transplants

2021 ◽  
Author(s):  
Yanhui Zhang ◽  
Hailu Zhang ◽  
Dehua Huang ◽  
Bo Tan ◽  
Chengxing Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Contrast Agent ◽  
Self Assembly ◽  
Mri Contrast Agent ◽  
Peptide Sequence ◽  
Mri Contrast ◽  
L929 Cells ◽  
Cell Transplants ◽  
Stem Cell Transplants ◽  
T2 Mri

Naphthalene is coupled with DOTA via a peptide sequence to yield an amphipathic MRI probe Nap-CFGKTG-DOTA-Gd (Nap-Gd) that can self-assemble into nanofibers. Incubation of NSCs, hMSCs and L929 cells in...

scholarly journals A chronic 1 year assessment of MRI contrast agent-labelled neural stem cell transplants in stroke

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. T133-T142 ◽  
Author(s):  
M. Modo ◽  
J.S. Beech ◽  
T.J. Meade ◽  
S.C.R. Williams ◽  
J. Price
Keyword(s):  
Stem Cell ◽  
Contrast Agent ◽  
Neural Stem Cell ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Cell Transplants ◽  
Stem Cell Transplants

Cobalt ferrite nanowhiskers as T2 MRI contrast agent

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17223-17227 ◽  
Author(s):  
M. Ravichandran ◽  
Goldie Oza ◽  
S. Velumani ◽  
Jose Tapia Ramirez ◽  
Francisco Garcia-Sierra ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Cobalt Ferrite ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
One Dimensional ◽  
One Step ◽  
T2 Mri

A novel, one-step synthesis of one-dimensional cobalt ferrite nanowhiskers (CfW) is reported.

scholarly journals Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 86779-86783 ◽  
Author(s):  
M. Borges ◽  
S. Yu ◽  
A. Laromaine ◽  
A. Roig ◽  
S. Suárez-García ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Coordination Polymer ◽  
Contrast Agent ◽  
Polymer Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Agent Based ◽  
Iron Coordination ◽  
T2 Mri

A novel dual T1/T21H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed.

Cell-assembled (Gd-DOTA)i-triphenylphosphonium (TPP) nanoclusters as a T2 contrast agent reveal in vivo fates of stem cell transplants

Nano Research ◽  
2018 ◽  
Vol 11 (3) ◽  
pp. 1625-1641 ◽  
Author(s):  
Yanhui Zhang ◽  
Hongyan Zhang ◽  
Binbin Li ◽  
Hailu Zhang ◽  
Bo Tan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Contrast Agent ◽  
Cell Transplants ◽  
Stem Cell Transplants

scholarly journals PS224. Porcine Mesenchymal Stem Cell Labeling with MRI Contrast Agent Ferex

2011 ◽  
Vol 53 (6) ◽  
pp. 87S-88S
Author(s):  
Mehrnoosh Shahrivar ◽  
Daniel K. Han ◽  
Karen Briley-Saebo ◽  
Andrew Tye ◽  
Michael L. Marin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Cell Labeling ◽  
Mri Contrast

A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent

2014 ◽  
Vol 2 (32) ◽  
pp. 5295-5301 ◽  
Author(s):  
Weiren Cheng ◽  
Reshmi Rajendran ◽  
Wei Ren ◽  
Liuqun Gu ◽  
Yong Zhang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Side Effects ◽  
Contrast Agent ◽  
Self Assembly ◽  
Mri Contrast Agent ◽  
Synthetic Approach ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Low Cytotoxicity

A biodegradable novel polydisulfide MRI contrast agent forming self-assembly in aqueous solution with a low cytotoxicity and a higherr1is promising for producing better MRI imaging with fewer side effects.

scholarly journals New Class of Efficient T2 Magnetic Resonance Imaging Contrast Agent: Carbon-Coated Paramagnetic Dysprosium Oxide Nanoparticles

2020 ◽  
Vol 13 (10) ◽  
pp. 312
Author(s):  
Huan Yue ◽  
Ji Ae Park ◽  
Son Long Ho ◽  
Mohammad Yaseen Ahmad ◽  
Hyunsil Cha ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Magnetic Moments ◽  
Negative Contrast ◽  
Mri Contrast Agents ◽  
Proton Spin ◽  
Mri Contrast Agent ◽  
Water Proton ◽  
Dysprosium Oxide ◽  
Mri Contrast ◽  
T2 Mri

Nanoparticles are considered potential candidates for a new class of magnetic resonance imaging (MRI) contrast agents. Negative MRI contrast agents require high magnetic moments. However, if nanoparticles can exclusively induce transverse water proton spin relaxation with negligible induction of longitudinal water proton spin relaxation, they may provide negative contrast MR images despite having low magnetic moments, thus acting as an efficient T2 MRI contrast agent. In this study, carbon-coated paramagnetic dysprosium oxide (DYO@C) nanoparticles (core = DYO = DyxOy; shell = carbon) were synthesized to explore their potential as an efficient T2 MRI contrast agent at 3.0 T MR field. Since the core DYO nanoparticles have an appreciable (but not high) magnetic moment that arises from fast 4f-electrons of Dy(III) (6H15/2), the DYO@C nanoparticles exhibited an appreciable transverse water proton spin relaxivity (r2) with a negligible longitudinal water proton spin relaxivity (r1). Consequently, they acted as a very efficient T2 MRI contrast agent, as proven from negative contrast enhancements seen in the in vivo T2 MR images.

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