Gelatin methacryloyl hydrogels functionalized with endothelin-1 for angiogenesis and full-thickness wound healing

Natural polymer hydrogels widely emerged as wound dressings, but they had not enough bioactivity to accelerate angiogenesis and re-epithelialization. Herein, we firstly constructed a therapeutic system in which endothelin-1 (ET-1)...

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Fabrication of sliver nanoparticles/polyvinyl alcohol/gelatin ternary nanofiber mats for wound healing application

Journal of Biomaterials Applications ◽

10.1177/0885328220927317 ◽

2020 ◽

Vol 35 (2) ◽

pp. 287-298

Author(s):

Somaya Amer ◽

Noha Attia ◽

Samir Nouh ◽

Mahmoud El-Kammar ◽

Ahmed Korittum ◽

...

Keyword(s):

Wound Healing ◽

Polyvinyl Alcohol ◽

Wound Dressings ◽

Full Thickness ◽

Microbial Invasion ◽

Thickness Skin ◽

Nanofiber Mats ◽

Full Thickness Wound

Purpose In this study, we aimed to determine the regenerative and antimicrobial impact of the electrospun nanofiber mats, with/without silver nanoparticles (AgNPs), on full-thickness skin wounds in rabbits. Methods Polyvinyl alcohol was combined with gelatin to provide biocompatible electrospun binary nanofiber mats. AgNPs were added to the polyvinyl alcohol/gelatin mixture to obtain ternary nanofiber-AgNPs mats. Binary and ternary nanofiber mats were characterized by scanning electron microscopy before being applied as wound dressings in vivo. Subsequently, wound healing was evaluated. Results Both nanofiber/nanofiber-AgNPs mats improved the microscopic quality of the healed skin, albeit without obvious acceleration of the healing rate. As well, both types of nanofiber mats were able to combat microbial invasion into the wound bed. Conclusions Both binary polyvinyl alcohol/gelatin and ternary polyvinyl alcohol/gelatin/AgNPs nanofiber mats developed in the present study depicted similar regenerative and antimicrobial potential when applied as full-thickness wound dressing. However, in comparison to the binary nanofiber mats, no obvious synergistic effect was observed after loading nanofibers with AgNPs.

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Generation of Nano-pores in Silk Fibroin Films Using Silk Nanoparticles for Full-Thickness Wound Healing

Biomacromolecules ◽

10.1021/acs.biomac.0c01411 ◽

2021 ◽

Vol 22 (2) ◽

pp. 546-556

Author(s):

Jian Liu ◽

Ran Huang ◽

Gang Li ◽

David L. Kaplan ◽

Zhaozhu Zheng ◽

...

Keyword(s):

Wound Healing ◽

Silk Fibroin ◽

Full Thickness ◽

Full Thickness Wound

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A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization, extracellular matrix deposition, and nerve regeneration

Biomaterials Science ◽

10.1039/d1bm00357g ◽

2021 ◽

Author(s):

Hao Li ◽

Mengna Li ◽

Pei Liu ◽

Kai-Yang Wang ◽

Haoyu Fang ◽

...

Keyword(s):

Extracellular Matrix ◽

Wound Healing ◽

Full Thickness ◽

Matrix Deposition ◽

Chitosan Hydrochloride ◽

Reconstructive Microsurgery ◽

Extracellular Matrix Deposition ◽

Advanced Biomaterials ◽

Native Skin ◽

Full Thickness Wound

Due to the native skin limitations and the complexity of reconstructive microsurgery, advanced biomaterials are urgently required to promote wound healing for severe skin defects caused by accidents and disasters....

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