Enaminones in the mannich reaction. Part 2. Further investigations of internal mannich reactions

1979 ◽  
pp. 1593 ◽  
Author(s):  
Ibrahim Chaaban ◽  
John V. Greenhill ◽  
Pervez Akhtar
Keyword(s):  
Mannich Reaction ◽  
Mannich Reactions ◽  
The Mannich Reaction

New tartrate based cyclic phosphoric acids as organocatalysts in Mannich reactions

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Tuvshinjargal Budragchaa ◽  
Michael Abraham ◽  
Wolfgang Schöfberger ◽  
Alexander Roller ◽  
Michael Widhalm
Keyword(s):  
Crystal Structure ◽  
Dft Calculations ◽  
Structure Analysis ◽  
Mannich Reaction ◽  
Structural Variation ◽  
Crystal Structure Analysis ◽  
Mannich Reactions ◽  
Optimization Study ◽  
The Mannich Reaction ◽  
Phosphoric Acids

Abstract Cyclic phosphoric acids have attracted much attention as chiral organocatalysts. While binaphthol based ligands have been extensively used in various transformations, the analogous TADDOL-type ligands are less explored. A library of seventeen cyclic phosphoric acids with structural variation of the TADDOL backbone were synthesized and an optimization study of the Mannich reaction of aromatic N-(2-hydroxyphenyl)imines with 2,2-dimethyl-1-methoxy-silylenolate was performed. Enantioselectivities between 96% (S) and 70% (R) were observed and a rationalisation, based on crystal structure analysis and DFT calculations, is provided.

In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

2017 ◽  
Vol 15 (21) ◽  
pp. 4527-4530 ◽  
Author(s):  
Taichi Kano ◽  
Chihiro Homma ◽  
Keiji Maruoka
Keyword(s):  
Mannich Reaction ◽  
Aldol Reaction ◽  
Quaternary Carbon ◽  
Mannich Reactions ◽  
The Mannich Reaction ◽  
In Situ Generation

Mannich reactions of β-dicarbonyls with in situ generated less accessible Boc-imines from aldehydes were achieved.

scholarly journals Recent advances and prospects in the Zn-catalysed Mannich reaction

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9098-9111
Author(s):  
Salahudeen Shamna ◽  
C. M. A. Afsina ◽  
Rose Mary Philip ◽  
Gopinathan Anilkumar
Keyword(s):  
Carbonyl Compound ◽  
Secondary Amine ◽  
Mannich Reaction ◽  
Mannich Base ◽  
Mannich Reactions ◽  
Recent Advances ◽  
Primary Secondary Amine

Amino alkylation of an acidic α-proton of a carbonyl by formaldehyde and a primary/secondary amine or ammonia, affording a β-amino-carbonyl compound also known as a Mannich base is a valuable reaction. We focus on recent advances in Zn catalysed Mannich reactions.

The Mannich Reaction Between Aromatic Ketones, Aromatic Aldehydes and Aromatic Amines

Synthesis ◽  
1991 ◽  
Vol 1991 (09) ◽  
pp. 717-718 ◽  
Author(s):  
Yi Lin ◽  
Lei Huangshu ◽  
Zou Junhua ◽  
Xu Xiujuan
Keyword(s):  
Mannich Reaction ◽  
Aromatic Amines ◽  
Aromatic Aldehydes ◽  
Aromatic Ketones ◽  
The Mannich Reaction
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