scholarly journals The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex

2015 ◽  
Vol 468 (2) ◽  
pp. 345-352 ◽  
Author(s):  
Venkatadri Kolla ◽  
Koumudi Naraparaju ◽  
Tiangang Zhuang ◽  
Mayumi Higashi ◽  
Sriharsha Kolla ◽  
...  
Keyword(s):  
Dna Binding ◽  
Histone Deacetylase ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Dna Binding Domain ◽  
Nurd Complex ◽  
Chromatin Remodelling Complex ◽  
Functional Differences ◽  
Domain Protein ◽  
Novel Protein

Chromodomain helicase DNA-binding protein 5 (CHD5) is localized exclusively in nucleus and forms nucleosome remodelling histone deacetylase (NuRD) complex with metastasis-associated protein (MTA)1/2, GATAD2A, histone deacetylase (HDAC)1/2, retinoblastoma-binding protein (RBBP)4/7 and methyl DNA-binding domain protein (MBD)3. Novel protein associations with CHD5–NuRD may account for the functional differences compared with CHD4–NuRD.

scholarly journals Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

2012 ◽  
Vol 288 (6) ◽  
pp. 4103-4115 ◽  
Author(s):  
Michaeline L. Hebron ◽  
Irina Lonskaya ◽  
Kaydee Sharpe ◽  
Puwakdandawe P. K. Weerasinghe ◽  
Norah K. Algarzae ◽  
...  
Keyword(s):  
Dna Binding ◽  
Histone Deacetylase ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Histone Deacetylase 6

scholarly journals Crystal Structure of the Chromodomain Helicase DNA-binding Protein 1 (Chd1) DNA-binding Domain in Complex with DNA

2011 ◽  
Vol 286 (49) ◽  
pp. 42099-42104 ◽  
Author(s):  
Amit Sharma ◽  
Katherine R. Jenkins ◽  
Annie Héroux ◽  
Gregory D. Bowman
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Binding Domain ◽  
Dna Binding Domain

The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein

1989 ◽  
Vol 9 (9) ◽  
pp. 4091-4095 ◽  
Author(s):  
C Buchman ◽  
P Skroch ◽  
J Welch ◽  
S Fogel ◽  
M Karin
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Regulatory Gene ◽  
Point Mutations ◽  
Dna Binding Protein ◽  
Binding Activity ◽  
Dna Binding Domain ◽  
Yeast Saccharomyces Cerevisiae ◽  
Dna Binding Activity ◽  
Yeast Strains

CUP2 is a regulatory gene controlling expression of CUP1, which encodes the Cu-binding yeast metallothionein. CUP2, which is identical to the ACE1 gene, encodes a Cu-regulated DNA-binding protein. The CUP2 protein contains a cysteine-rich DNA-binding domain dependent on Cu+ and Ag+ ions which bind the cysteine residues and direct the refolding of the metal-free apoprotein. CUP2 mutant alleles from Cu-sensitive yeast strains have point mutations affecting the DNA-binding activity. These results establish CUP2 as the primary sensor of intracellular Cu+ in the yeast Saccharomyces cerevisiae, functioning as a Cu+-regulated transcriptional activator.

scholarly journals Tomato MBD5, a methyl CpG binding domain protein, physically interacting with UV-damaged DNA binding protein-1, functions in multiple processes

2015 ◽  
Vol 210 (1) ◽  
pp. 208-226 ◽  
Author(s):  
Yuxiang Li ◽  
Heng Deng ◽  
Min Miao ◽  
Huirong Li ◽  
Shengxiong Huang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Binding Domain ◽  
Multiple Processes ◽  
Domain Protein ◽  
Damaged Dna
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