Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture
Keyword(s):
The incorporation and metabolism of both vesicle- and LDL (low-density lipoprotein)- derived [3H]cholesterol by LDL-receptor-negative fibroblasts were studied. Independent of the cholesterol source, free [3H]cholesterol was readily incorporated into the cells and was available for esterification. 7-Oxocholesterol stimulated both [3H]cholesterol incorporation, by increasing the exchange rate, and the subsequent esterification of it irrespective of the source of exogenous [3H]cholesterol. The 7-oxocholesterol-stimulated esterification of exogenously derived LDL free [3H]cholesterol was progesterone-sensitive and energy-requiring.
1978 ◽
Vol 253
(11)
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pp. 3852-3856
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1987 ◽
Vol 145
(1)
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pp. 350-356
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1975 ◽
Vol 55
(4)
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pp. 783-793
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2017 ◽
Vol 97
(3)
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pp. 1211-1228
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