Demonstration of the Control of Rabbit Skeletal-Muscle Phosphorylase Kinase Activity in vivo by Adenosine 3′5′-Cyclic Monophosphate-Dependent Protein Kinase

1974 ◽  
Vol 2 (5) ◽  
pp. 931-932 ◽  
Author(s):  
STEPHEN J. YEAMAN ◽  
PHILIP COHEN
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Kinase Activity ◽  
Rabbit Skeletal Muscle ◽  
Phosphorylase Kinase ◽  
Dependent Protein Kinase ◽  
Cyclic Monophosphate ◽  
Dependent Protein ◽  
Muscle Phosphorylase

scholarly journals Phosphorylation of the inhibitory subunit of troponin in perfused hearts of mice deficient in phosphorylase kinase. Evidence for the phosphorylation of troponin by adenosine 3′:5′-phosphate-dependent protein kinase in vivo

1977 ◽  
Vol 168 (2) ◽  
pp. 307-310 ◽  
Author(s):  
P J England
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Kinase Activity ◽  
Troponin I ◽  
Protein Kinase Activity ◽  
Phosphorylase Kinase ◽  
Dependent Protein Kinase ◽  
Parallel Increase ◽  
Dependent Protein

When hearts from control and phosphorylase kinase-deficient (I strain) mice were perfused with 0.1 micrometer-DL-isoprenaline, there was a parallel increase in contraction, cyclic AMP concentration and troponin I phosphorylation. However, there was no increase in phosphorylase a in the I-strain hearts, whereas the control hearts showed a large increase. Assays of I-strain heart extracts showed a normal cyclic AMP-dependent protein kinase activity but no phosphorylase kinase activity. It is concluded that troponin I is phosphorylated in intact hearts by protein kinase and not phosphorylase kinase.

Effect of Epinephrine and Insulin on Adenosine 3'5'-Cyclic Monophosphate - Dependent Protein Kinase in Human Skeletal Muscle In Vivo

1978 ◽  
Vol 10 (03) ◽  
pp. 208-213 ◽  
Author(s):  
A. Roch-Norlund ◽  
R. Horn ◽  
K. Gautvik ◽  
E. Walaas ◽  
O. Walaas
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Human Skeletal Muscle ◽  
Dependent Protein Kinase ◽  
Cyclic Monophosphate ◽  
Dependent Protein

scholarly journals The phosphorylation of troponin I from cardiac muscle

1975 ◽  
Vol 149 (3) ◽  
pp. 525-533 ◽  
Author(s):  
H A Cole ◽  
S V Perry
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Cardiac Muscle ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Phosphorylase Kinase ◽  
Dependent Protein Kinase ◽  
Dependent Protein

1. Troponin I isolated from fresh cardiac muscle by affinity chromatography contains about 1.9 mol of covalently bound phosphate/mol. Similar preparations of white-skeletal-muscle troponin I contain about 0.5 mol of phosphate/mol. 2. A 3':5'-cyclic AMP-dependent protein kinase and a protein phosphatase are associated with troponin isolated from cardiac muscle. 3. Bovine cardiac 3':5'-cyclic AMP-dependent protein kinase catalyses the phosphorylation of cardiac troponin I 30 times faster than white-skeletal-muscle troponin I. 4. Troponin I is the only component of cardiac troponin phosphorylated at a significant rate by the endogenous or a bovine cardiac 3':5'-cyclic AMP-dependent protein kinase. 5. Phosphorylase kinase catalyses the phosphorylation of cardiac troponin I at similar or slightly faster rates than white-skeletal-muscle troponin I. 6. Troponin C inhibits the phosphorylation of cardiac and skeletal troponin I catalysed by phosphorylase kinase and the phosphorylation of white skeletal troponin I catalysed by 3':5'-cyclic AMP-dependent protein kinase; the phosphorylation of cardiac troponin I catalysed by the latter enzyme is not inhibited.

Generation, characterization and ELISA of monospecific antibodies against the subunits of a Ca2+-dependent protein kinase and a Ca2+-transport ATPase from rabbit skeletal muscle

1984 ◽  
Vol 70 (2) ◽  
pp. 193-209 ◽  
Author(s):  
Hannelore Böhm ◽  
Jörg K.H. Petersen-Von Gehr ◽  
Horst P. Neubauer ◽  
Franz E. Mehnert ◽  
Herbert P. Jennissen
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Rabbit Skeletal Muscle ◽  
Dependent Protein Kinase ◽  
Transport Atpase ◽  
Dependent Protein ◽  
Monospecific Antibodies
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