Blood flow and net amino acid uptake by the lactating mammary gland: effect of starvation

1985 ◽  
Vol 13 (5) ◽  
pp. 876-877 ◽  
Author(s):  
JUAN R. VIÑA ◽  
ARGIMIRO RODRIGUEZ ◽  
JUAN B. MONTORO ◽  
ANTONIO IRADI ◽  
INMACULADA R. PUERTES ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

Control of amino acid uptake by the lactating mammary gland of the rat

1981 ◽  
Vol 9 (5) ◽  
pp. 392-392 ◽  
Author(s):  
JUAN R. VIÑA ◽  
JUAN B. MONTORO ◽  
INMACULADA R. PUERTES ◽  
JOSE VIÑA
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

Are the γ-glutamyl-amino acids signals for the amino acid uptake by lactating mammary gland?

1986 ◽  
Vol 14 (2) ◽  
pp. 311-312 ◽  
Author(s):  
JUAN R. VIÑA ◽  
INMACULADA R. PUERTES ◽  
JUAN B. MONTORO ◽  
ARGIMIRO RODRIGUEZ ◽  
JOSÉ VIÑA
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

scholarly journals Role of prolactin in amino acid uptake by the lactating mammary gland of the rat

FEBS Letters ◽  
1981 ◽  
Vol 126 (2) ◽  
pp. 250-252 ◽  
Author(s):  
José Viña ◽  
Inmaculada R. Puertes ◽  
Guillermo T. Saez ◽  
Juan R. Viña
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

scholarly journals Effect of premature weaning on amino acid uptake by the mammary gland of lactating rats

1981 ◽  
Vol 200 (3) ◽  
pp. 705-708 ◽  
Author(s):  
J R Viña ◽  
I R Puertes ◽  
J Viña
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Mammary Glands ◽  
Acid Uptake ◽  
Gamma Glutamyltransferase ◽  
Gamma Glutamyl ◽  
Lactating Mammary Gland

1. Arteriovenous differences of amino acids across the lactating mammary gland were measured in normal rats and weaned for 4, 5 and 24h. 2. Uptake of amino acids by mammary glands of rats weaned for 5h or more was significantly lower than that of controls. This was not reversed by injection of prolactin. 3. By using ‘unilaterally weaned’ rats we showed that milk accumulation plays an important role in amino acid uptake by mammary gland. 4. gamma-Glutamyltransferase activity was significantly lower in ‘weaned’ glands than in ‘normal’ glands. This provides further support for the hypothesis of the function of the gamma-glutamyl cycle in the mammary gland in vivo.

scholarly journals Involvement of γ-glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat

1981 ◽  
Vol 194 (1) ◽  
pp. 99-102 ◽  
Author(s):  
J Viña ◽  
I R Puertes ◽  
J M Estrela ◽  
J R Viña ◽  
J L Galbis
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Reduced Glutathione ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Gamma Glutamyltransferase ◽  
Lactating Mammary Gland ◽  
High Concentrations

1. Arteriovenous differences of amino acids across the lactating mammary gland have been measured in normal rats and in rats injected with serine–borate (an inhibitor of gamma-glutamyltransferase). 2. Comparison of the arteriovenous differences show that gamma-glutamyltransferase is involved in amino-acid uptake by the gland. 3. Reduced-glutathione content of isolated acini incubated with high concentrations of amino acids was lower than that of the controls. 4. High concentrations of amino acids had no effect on reduced-glutathione content of isolated acini when serine–borate was added to the incubation medium. 5. The findings provide evidence for the functioning of the gamma-glutamyl cycle in the lactating mammary gland in vivo.

Gamma-Glutamyl-Amino Acids as Signals for the Hormonal Regulation of Amino Acid Uptake by the Mammary Gland of the Lactating Rat

Neonatology ◽  
1985 ◽  
Vol 48 (4) ◽  
pp. 250-256 ◽  
Author(s):  
Juan R. Viña ◽  
Inmaculada R. Puertes ◽  
Juan B. Montoro ◽  
Guillermo T. Saez ◽  
José Viña
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Hormonal Regulation ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Gamma Glutamyl

Plasma amino acid uptake by the mammary gland of the lactating sow.

1997 ◽  
Vol 75 (5) ◽  
pp. 1266 ◽  
Author(s):  
N L Trottier ◽  
C F Shipley ◽  
R A Easter
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Plasma Amino Acid ◽  
Acid Uptake ◽  
Lactating Sow

scholarly journals Spatial Heterogeneity of Low-Grade Gliomas at the Capillary Level: A PET Study on Tumor Blood Flow and Amino Acid Uptake

2007 ◽  
Vol 48 (7) ◽  
pp. 1047-1052 ◽  
Author(s):  
M. T. Wyss ◽  
S. Hofer ◽  
M. Hefti ◽  
E. Bartschi ◽  
C. Uhlmann ◽  
...  
Keyword(s):  
Blood Flow ◽  
Amino Acid ◽  
Spatial Heterogeneity ◽  
Amino Acid Uptake ◽  
Low Grade ◽  
Acid Uptake ◽  
Tumor Blood Flow ◽  
Low Grade Gliomas

Direct infusion of a variant of insulin-like growth factor-I into the skin of sheep and effects on local blood flow, amino acid utilization and cell replication

1993 ◽  
Vol 139 (3) ◽  
pp. 463-472 ◽  
Author(s):  
P. M. Harris ◽  
B. W. McBride ◽  
M. P. Gurnsey ◽  
B. R. Sinclair ◽  
J. Lee
Keyword(s):  
Blood Flow ◽  
Amino Acid ◽  
Growth Factor ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Amino Acid Utilization ◽  
Igf I ◽  
Growth Factor I

ABSTRACT In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum. An artery and vein on the abdominal flank of each animal, as well as the saphenous artery, were catheterized so that infusion of isotopically labelled amino acids, with or without IGF-I, could be used to determine amino acid uptake by arteriovenous difference in combination with blood flow determined by dye dilution. Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased. Numbers of cells replicating in the bulbs of wool follicles in the IGF-I-infused area and in the skin on the contralateral side of each animal were measured after labelling with 5-bromo-2′-deoxyuridine. IGF-I caused a significant increase in the skin blood flow (P<0·05), utilization of oxygen (P<0·05), uptake of cysteine (P<0·05) and phenylalanine (P<0·001), and the rate of utilization of cysteine (P<0·05) for protein synthesis. IGF-I increased amino acid uptake regardless of whether the skin was in negative or positive amino acid balance prior to infusion. During the recovery period amino acid utilization by skin returned towards preinfusion levels. No effects of IGF-I were found on replicating cell numbers in the bulbs of wool follicles. Journal of Endocrinology (1993) 139, 463–472

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