scholarly journals Spatial Heterogeneity of Low-Grade Gliomas at the Capillary Level: A PET Study on Tumor Blood Flow and Amino Acid Uptake

2007 ◽  
Vol 48 (7) ◽  
pp. 1047-1052 ◽  
Author(s):  
M. T. Wyss ◽  
S. Hofer ◽  
M. Hefti ◽  
E. Bartschi ◽  
C. Uhlmann ◽  
...  
Keyword(s):  
Blood Flow ◽  
Amino Acid ◽  
Spatial Heterogeneity ◽  
Amino Acid Uptake ◽  
Low Grade ◽  
Acid Uptake ◽  
Tumor Blood Flow ◽  
Low Grade Gliomas

High amino acid uptake in a low-grade desmoplastic infantile ganglioglioma in a 14-year-old patient

1998 ◽  
Vol 21 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Burkhard Woesler ◽  
Torsten Kuwerte ◽  
Gerhard Kurlemann ◽  
Carlo Morgenroth ◽  
Stefan Probst-Cousin ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Uptake ◽  
Low Grade ◽  
Acid Uptake ◽  
Desmoplastic Infantile Ganglioglioma ◽  
High Amino Acid

Blood flow and net amino acid uptake by the lactating mammary gland: effect of starvation

1985 ◽  
Vol 13 (5) ◽  
pp. 876-877 ◽  
Author(s):  
JUAN R. VIÑA ◽  
ARGIMIRO RODRIGUEZ ◽  
JUAN B. MONTORO ◽  
ANTONIO IRADI ◽  
INMACULADA R. PUERTES ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

Direct infusion of a variant of insulin-like growth factor-I into the skin of sheep and effects on local blood flow, amino acid utilization and cell replication

1993 ◽  
Vol 139 (3) ◽  
pp. 463-472 ◽  
Author(s):  
P. M. Harris ◽  
B. W. McBride ◽  
M. P. Gurnsey ◽  
B. R. Sinclair ◽  
J. Lee
Keyword(s):  
Blood Flow ◽  
Amino Acid ◽  
Growth Factor ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Amino Acid Utilization ◽  
Igf I ◽  
Growth Factor I

ABSTRACT In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum. An artery and vein on the abdominal flank of each animal, as well as the saphenous artery, were catheterized so that infusion of isotopically labelled amino acids, with or without IGF-I, could be used to determine amino acid uptake by arteriovenous difference in combination with blood flow determined by dye dilution. Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased. Numbers of cells replicating in the bulbs of wool follicles in the IGF-I-infused area and in the skin on the contralateral side of each animal were measured after labelling with 5-bromo-2′-deoxyuridine. IGF-I caused a significant increase in the skin blood flow (P<0·05), utilization of oxygen (P<0·05), uptake of cysteine (P<0·05) and phenylalanine (P<0·001), and the rate of utilization of cysteine (P<0·05) for protein synthesis. IGF-I increased amino acid uptake regardless of whether the skin was in negative or positive amino acid balance prior to infusion. During the recovery period amino acid utilization by skin returned towards preinfusion levels. No effects of IGF-I were found on replicating cell numbers in the bulbs of wool follicles. Journal of Endocrinology (1993) 139, 463–472

scholarly journals Molecular Imaging of Brain Tumor-Associated Epilepsy

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1049
Author(s):  
Csaba Juhász ◽  
Sandeep Mittal
Keyword(s):  
Brain Tumor ◽  
Amino Acid ◽  
Brain Tumors ◽  
Treatment Strategies ◽  
Amino Acid Uptake ◽  
Seizure Outcome ◽  
Acid Uptake ◽  
Positron Emission ◽  
Oncology Practice ◽  
Glioneuronal Tumors

Epilepsy is a common clinical manifestation and a source of significant morbidity in patients with brain tumors. Neuroimaging has a pivotal role in neuro-oncology practice, including tumor detection, differentiation, grading, treatment guidance, and posttreatment monitoring. In this review, we highlight studies demonstrating that imaging can also provide information about brain tumor-associated epileptogenicity and assist delineation of the peritumoral epileptic cortex to optimize postsurgical seizure outcome. Most studies focused on gliomas and glioneuronal tumors where positron emission tomography (PET) and advanced magnetic resonance imaging (MRI) techniques can detect metabolic and biochemical changes associated with altered amino acid transport and metabolism, neuroinflammation, and neurotransmitter abnormalities in and around epileptogenic tumors. PET imaging of amino acid uptake and metabolism as well as activated microglia can detect interictal or peri-ictal cortical increased uptake (as compared to non-epileptic cortex) associated with tumor-associated epilepsy. Metabolic tumor volumes may predict seizure outcome based on objective treatment response during glioma chemotherapy. Advanced MRI, especially glutamate imaging, can detect neurotransmitter changes around epileptogenic brain tumors. Recently, developed PET radiotracers targeting specific glutamate receptor types may also identify therapeutic targets for pharmacologic seizure control. Further studies with advanced multimodal imaging approaches may facilitate development of precision treatment strategies to control brain tumor-associated epilepsy.

scholarly journals Polyribonucleotide Synthesis and Bacterial Amino Acid Uptake: the Work of Leon A. Heppel

2007 ◽  
Vol 282 (18) ◽  
pp. e13-e15
Author(s):  
Nicole Kresge ◽  
Robert D. Simoni ◽  
Robert L. Hill
Keyword(s):  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake

scholarly journals Amino Acid Transporters on the Guard of Cell Genome and Epigenome

Cancers ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 125
Author(s):  
Uğur Kahya ◽  
Ayşe Sedef Köseer ◽  
Anna Dubrovska
Keyword(s):  
Amino Acid ◽  
Cancer Metabolism ◽  
Tumor Imaging ◽  
Redox Homeostasis ◽  
Amino Acid Uptake ◽  
Metabolic Reprogramming ◽  
Tumor Evolution ◽  
Amino Acid Transporters ◽  
Acid Uptake ◽  
Growth And Survival

Tumorigenesis is driven by metabolic reprogramming. Oncogenic mutations and epigenetic alterations that cause metabolic rewiring may also upregulate the reactive oxygen species (ROS). Precise regulation of the intracellular ROS levels is critical for tumor cell growth and survival. High ROS production leads to the damage of vital macromolecules, such as DNA, proteins, and lipids, causing genomic instability and further tumor evolution. One of the hallmarks of cancer metabolism is deregulated amino acid uptake. In fast-growing tumors, amino acids are not only the source of energy and building intermediates but also critical regulators of redox homeostasis. Amino acid uptake regulates the intracellular glutathione (GSH) levels, endoplasmic reticulum stress, unfolded protein response signaling, mTOR-mediated antioxidant defense, and epigenetic adaptations of tumor cells to oxidative stress. This review summarizes the role of amino acid transporters as the defender of tumor antioxidant system and genome integrity and discusses them as promising therapeutic targets and tumor imaging tools.

scholarly journals Studies on Aromatic Amino Acid Uptake by Rat Brain in Vivo

1962 ◽  
Vol 237 (3) ◽  
pp. 803-806
Author(s):  
Gordon Guroff ◽  
Sidney Udenfriend
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Aromatic Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake
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