Why and how are peptide-lipid interactions utilised for self-defence?

2001 ◽  
Vol 29 (3) ◽  
pp. A56-A56
Author(s):  
K. Matsuzaki
Keyword(s):  
Lipid Interactions ◽  
Self Defence

Why and how are peptide-lipid interactions utilized for self defence?

2001 ◽  
Vol 29 (4) ◽  
pp. 598-601 ◽  
Author(s):  
K. Matsuzaki
Keyword(s):  
Supramolecular Complex ◽  
Effective Mechanism ◽  
Bacterial Membranes ◽  
Lipid Interactions ◽  
Peptide Molecule ◽  
Transport Of Ions ◽  
Β Sheets ◽  
Micro Organisms ◽  
Microbial Action ◽  
Self Defence

Animals defend themselves against invading pathogenic micro-organisms by utilizing cationic anti-microbial peptides, which rapidly kill various micro-organisms without exerting toxicity against the host. Physicochemical peptide-lipid interactions provide attractive mechanisms for innate immunity. Many of these peptides form amphipathic secondary structures (α-helices and β-sheets) which can selectively interact with anionic bacterial membranes by electrostatic interaction. Rapid, peptide-induced membrane permeabilization is an effective mechanism of anti-microbial action. Magainin 2 from frog skin forms a dynamic peptide-lipid supramolecular-complex pore that allows mutually coupled transmembrane transport of ions and lipids. The peptide molecule is internalized upon the disintegration of the pore. Several anti-microbial peptides are known to work synergistically.

War, Aggression and Self-Defence

2017 ◽  
Author(s):  
Yoram Dinstein
Keyword(s):  
Self Defence

When Self-Defence Fails

2017 ◽  
Author(s):  
Elizabeth A. Sheehy ◽  
Julie Stubbs ◽  
Julia Tolmie
Keyword(s):  
Self Defence

scholarly journals The relationship between protein-protein and protein-lipid interactions and the immunological properties of bovine prothrombin and several of its fragments.

1982 ◽  
Vol 257 (4) ◽  
pp. 1836-1844
Author(s):  
D.A. Madar ◽  
M.M. Sarasua ◽  
H.C. Marsh ◽  
L.G. Pedersen ◽  
K.E. Gottschalk ◽  
...  
Keyword(s):  
Immunological Properties ◽  
Lipid Interactions ◽  
The Relationship
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