Analysis and modelling of signal transduction pathways in systems biology

2003 ◽  
Vol 31 (6) ◽  
pp. 1503-1509 ◽  
Author(s):  
K.-H. Cho ◽  
O. Wolkenhauer
Keyword(s):  
Signal Transduction ◽  
Systems Biology ◽  
Dynamic Systems ◽  
Biological Networks ◽  
Systems Approach ◽  
Life Sciences ◽  
Dynamic Modelling ◽  
Signal Transduction Pathways ◽  
Physical Sciences ◽  
Functional Relationships

There is general agreement that a systems approach is needed for a better understanding of causal and functional relationships that generate the dynamics of biological networks and pathways. These observations have been the basis for efforts to get the engineering and physical sciences involved in life sciences. The emergence of systems biology as a new area of research is evidence for these developments. Dynamic modelling and simulation of signal transduction pathways is an important theme in systems biology and is getting growing attention from researchers with an interest in the analysis of dynamic systems. This paper introduces systems biology in terms of the analysis and modelling of signal transduction pathways. Focusing on mathematical representations of cellular dynamics, a number of emerging challenges and perspectives are discussed.

Beacon Editor: Capturing Signal Transduction Pathways Using the Systems Biology Graphical Notation Activity Flow Language

2017 ◽  
Vol 24 (12) ◽  
pp. 1226-1229 ◽  
Author(s):  
Haitham Elmarakeby ◽  
Mostafa Arefiyan ◽  
Elijah Myers ◽  
Song Li ◽  
Ruth Grene ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Systems Biology ◽  
Signal Transduction Pathways ◽  
Graphical Notation

A dynamic systems approach to the life sciences

2009 ◽  
pp. 235-253 ◽  
Author(s):  
Alan Fogel ◽  
Stanley Greenspan ◽  
Barbara J. King ◽  
Robert Lickliter ◽  
Pedro Reygadas ◽  
...  
Keyword(s):  
Dynamic Systems ◽  
Systems Approach ◽  
Life Sciences

Systems and Control Theory for Medical Systems Biology

2009 ◽  
pp. 11-26
Author(s):  
Peter Wellstead ◽  
Sree Sreenath ◽  
Kwang-Hyun Cho
Keyword(s):  
Systems Biology ◽  
Control Theory ◽  
Systems Approach ◽  
Life Sciences ◽  
Medical Application ◽  
Medical Systems ◽  
Reference Base ◽  
Systems And Control ◽  
History Of ◽  
And Control

In this chapter the authors describe systems and control theory concepts for systems biology and the corresponding implications for medicine. The context for a systems approach to the life sciences is outlined, followed by a brief history of systems and control theory. The technical aspects of systems and control theory are then described in a way oriented toward their biological and medical application. This description is then used as a reference base against which to indicate specific areas where systems and control theory aspects of systems biology have strong medical implications. Specifically, two systems biology projects are described as examples of where methods from systems and control theory play an important role.

scholarly journals Approximations and their consequences for dynamic modelling of signal transduction pathways

2007 ◽  
Vol 207 (1) ◽  
pp. 40-57 ◽  
Author(s):  
Thomas Millat ◽  
Eric Bullinger ◽  
Johann Rohwer ◽  
Olaf Wolkenhauer
Keyword(s):  
Signal Transduction ◽  
Dynamic Modelling ◽  
Signal Transduction Pathways

Signal-regulated oxidation of proteins via MICAL

2020 ◽  
Vol 48 (2) ◽  
pp. 613-620
Author(s):  
Clara Ortegón Salas ◽  
Katharina Schneider ◽  
Christopher Horst Lillig ◽  
Manuela Gellert
Keyword(s):  
Signal Transduction ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Redox Regulation ◽  
Signal Transduction Pathways ◽  
Cellular Functions ◽  
Intracellular Signals ◽  
Amino Acid Side Chains ◽  
Specific Receptors ◽  
Sulfur Containing

Processing of and responding to various signals is an essential cellular function that influences survival, homeostasis, development, and cell death. Extra- or intracellular signals are perceived via specific receptors and transduced in a particular signalling pathway that results in a precise response. Reversible post-translational redox modifications of cysteinyl and methionyl residues have been characterised in countless signal transduction pathways. Due to the low reactivity of most sulfur-containing amino acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail before, the discovery and characterisation of MICAL proteins evinced the first examples of specific oxidases in signal transduction. This article provides an overview of the functions of MICAL proteins in the redox regulation of cellular functions.

A Dynamic Systems Approach to Personality

2001 ◽  
Vol 6 (3) ◽  
pp. 172-176 ◽  
Author(s):  
Lawrence A. Pervin
Keyword(s):  
Dynamic Systems ◽  
Systems Approach ◽  
Biological Processes ◽  
Recent Advances ◽  
Dynamic View ◽  
The Future ◽  
History Of

David Magnusson has been the most articulate spokesperson for a holistic, systems approach to personality. This paper considers three concepts relevant to a dynamic systems approach to personality: dynamics, systems, and levels. Some of the history of a dynamic view is traced, leading to an emphasis on the need for stressing the interplay among goals. Concepts such as multidetermination, equipotentiality, and equifinality are shown to be important aspects of a systems approach. Finally, attention is drawn to the question of levels of description, analysis, and explanation in a theory of personality. The importance of the issue is emphasized in relation to recent advances in our understanding of biological processes. Integrating such advances into a theory of personality while avoiding the danger of reductionism is a challenge for the future.

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