The emerging role of MS in structure elucidation of protein–nucleic acid complexes
2008 ◽
Vol 36
(4)
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pp. 723-731
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Keyword(s):
Developments in MS enable us to apply this technique to non-covalent complexes, defining their stoichiometry, subunit interactions and architectural organization. We illustrate the application of this non-covalent MS approach to uncovering the overall topological arrangements of subunits and interactions within RNA–protein complexes studied in our laboratory over the last 5 years. These studies exemplify the emerging role and potential of MS as a complementary structural biology methodology and demonstrate its unique niche in investigations of dynamic or heterogeneous protein–nucleic acid complexes, which are not accessible to classical high-resolution structural biology techniques.
1981 ◽
Vol 6
◽
pp. 137-139
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Keyword(s):
2006 ◽
Vol 273
(7)
◽
pp. 1463-1475
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2011 ◽
Vol 46
(2)
◽
pp. 152-164
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2004 ◽
Vol 279
(24)
◽
pp. 24907-24910
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2008 ◽
pp. 279-291
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