scholarly journals The Eyes Absent proteins in development and in developmental disorders

2021 ◽  
Author(s):  
Upendra Kumar Soni ◽  
Kaushik Roychoudhury ◽  
Rashmi S. Hegde
Keyword(s):  
Signaling Pathways ◽  
Cell Fate ◽  
Protein Tyrosine Phosphatase ◽  
Developmental Disorders ◽  
Tyrosine Phosphatase ◽  
Molecular Signaling ◽  
Eyes Absent ◽  
Multiple Organs ◽  
Transcriptional Regulatory ◽  
Broad Overview

The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation, morphogenesis and tissue homeostasis in different contexts. Aberrant EYA levels or activity are associated with numerous syndromic and non-syndromic developmental disorders, as well as cancers. Commensurate with the multiplicity of biochemical activities carried out by the EYA proteins, they impact upon a range of cellular signaling pathways. Here, we provide a broad overview of the roles played by EYA proteins in development, and highlight the molecular signaling pathways known to be linked with EYA-associated organ development and developmental disorders.

The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Jiajia Zhang ◽  
Ning Wu ◽  
Dayong Shi
Keyword(s):  
Signaling Pathways ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Mammalian Target Of Rapamycin ◽  
Eukaryotic Cell ◽  
Target Of Rapamycin ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Transduction Mechanisms ◽  
Specific Proteins

Background: The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes. Methodology: We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer. Results: We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases. Conclusion: There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.

scholarly journals The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth

2018 ◽  
Vol 17 (8) ◽  
pp. 1659-1669 ◽  
Author(s):  
Yuhua Wang ◽  
Ram Naresh Pandey ◽  
Stephen Riffle ◽  
Hemabindu Chintala ◽  
Kathryn A. Wikenheiser-Brokamp ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Phosphatase Activity ◽  
Tumor Angiogenesis ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Eyes Absent ◽  
Protein Tyrosine

scholarly journals eyes absent in the cockroach panoistic ovaries regulates proliferation and differentiation through ecdysone signalling

2019 ◽  
Author(s):  
S. Ramos ◽  
F. Chelemen ◽  
V. Pagone ◽  
N. Elshaer ◽  
P. Irles ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Ovarian Follicle ◽  
Tyrosine Phosphatase ◽  
Follicle Cells ◽  
Eyes Absent ◽  
Transcription Cofactor ◽  
Proliferation And Differentiation ◽  
Follicle Maturation ◽  
Germinal Cells ◽  
Steroidogenic Genes

AbstractEyes absent (Eya), is a protein structurally conserved from hydrozoans to humans, for which two basic roles have been reported: it can act as a transcription cofactor and as a protein tyrosine phosphatase. Eya was discovered in the fly Drosophila melanogaster in relation to its function in eye development, and the same function was later reported in other insects. Eya is also involved in insect oogenesis, although studies in this sense are limited to D. melanogaster, which has meroistic ovaries, and where eya mutations abolish gonad formation.In the present work we studied the function of eya in the panoistic ovary of the cockroach Blattella germanica. We show that eya is essential for correct development of panoistic ovaries. In B. germanica, eya acts at different level and in a distinct way in the germarium and the vitellarium. In the germarium, eya contributes to maintain the correct number of somatic and germinal cells by regulating the expression of steroidogenic genes in the ovary. In the vitellarium, eya facilitates follicle cells proliferation and contributes to regulate the cell program, in the context of basal ovarian follicle maturation. Thus, eya-depleted females of B. germanica arrest the growth and maturation of basal ovarian follicles and become sterile.

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