Puerarin protects differentiated PC12 cells from H2O2-induced apoptosis through the PI3K/Akt signalling pathway

2012 ◽  
Vol 36 (5) ◽  
pp. 419-426 ◽  
Author(s):  
Qin Zhang ◽  
Wei‑dong Huang ◽  
Xue‑ying Lv ◽  
Yun‑mei Yang
Keyword(s):  
Pc12 Cells ◽  
Signalling Pathway ◽  
Differentiated Pc12 Cells ◽  
Induced Apoptosis

Neuroprotection by new ligustrazine-cinnamon acid derivatives on CoCl2-induced apoptosis in differentiated PC12 cells

2018 ◽  
Vol 77 ◽  
pp. 360-369 ◽  
Author(s):  
Penglong Wang ◽  
Rui Zhao ◽  
Wenqiang Yan ◽  
Xinyu Zhang ◽  
Huazheng Zhang ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Differentiated Pc12 Cells ◽  
Induced Apoptosis

scholarly journals Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons

2000 ◽  
Vol 20 (1) ◽  
pp. 196-204 ◽  
Author(s):  
Takashi Kanamoto ◽  
Monica Mota ◽  
Kohsuke Takeda ◽  
Lee L. Rubin ◽  
Kohei Miyazono ◽  
...  
Keyword(s):  
Map Kinase ◽  
Pc12 Cells ◽  
Neuronal Apoptosis ◽  
Sympathetic Neurons ◽  
Active Form ◽  
P38 Map Kinase ◽  
Differentiated Pc12 Cells ◽  
Mitogen Activated Protein ◽  
Induced Apoptosis

ABSTRACT We have previously shown that nerve growth factor (NGF) withdrawal-induced death requires the activity of the small GTP-binding protein Cdc42 and that overexpression of an active form of Cdc42 is sufficient to mediate neuronal apoptosis via activation of the c-Jun pathway. Recently, a new mitogen-activated protein (MAP) kinase kinase kinase, apoptosis signal-regulating kinase 1 (ASK1) which activates both the c-Jun N-terminal kinase (JNK) and p38 MAP kinase pathways and plays pivotal roles in tumor necrosis factor- and Fas-induced apoptosis, has been identified. Therefore, we investigated the role of ASK1 in neuronal apoptosis by using rat pheochromocytoma (PC12) neuronal cells and primary rat sympathetic neurons (SCGs). Overexpression of ASK1-ΔN, a constitutively active mutant of ASK1, activated JNK and induced apoptosis in differentiated PC12 cells and SCG neurons. Moreover, in differentiated PC12 cells, NGF withdrawal induced a four- to fivefold increase in the activity of endogenous ASK1. Finally, expression of a kinase-inactive ASK1 significantly blocked both NGF withdrawal- and Cdc42-induced death and activation of c-jun. Taken together, these results demonstrate that ASK1 is a crucial element of NGF withdrawal-induced activation of the Cdc42–c-Jun pathway and neuronal apoptosis.

Caspase-8 Mediates Amyloid-β-induced Apoptosis in Differentiated PC12 Cells

2015 ◽  
Vol 56 (2) ◽  
pp. 491-499 ◽  
Author(s):  
Min-cai Qian ◽  
Jing Liu ◽  
Jia-shu Yao ◽  
Wei-min Wang ◽  
Jian-hong Yang ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Amyloid Β ◽  
Caspase 8 ◽  
Differentiated Pc12 Cells ◽  
Induced Apoptosis

Inhibition of LPS-induced apoptosis in differentiated-PC12 cells by new triazine derivatives through NF-κB-mediated suppression of COX-2

2010 ◽  
Vol 57 (8) ◽  
pp. 958-968 ◽  
Author(s):  
Niloufar Ansari ◽  
Fariba Khodagholi ◽  
Mahmoudreza Ramin ◽  
Mohsen Amini ◽  
Hamid Irannejad ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Differentiated Pc12 Cells ◽  
Triazine Derivatives ◽  
Cox 2 ◽  
Induced Apoptosis
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