The Effect of Methylguanidine on Tissue Respiration in Vitro

1971 ◽  
Vol 41 (1) ◽  
pp. 85-87 ◽  
Author(s):  
R. A. Felgate ◽  
W. H. Taylor
Keyword(s):  
Cerebral Cortex ◽  
Oxygen Uptake ◽  
Incubation Medium ◽  
Significant Inhibition ◽  
Rat Cerebral Cortex ◽  
Tissue Respiration ◽  
Chronic Uraemia

1. Slices of rat cerebral cortex, kidney and liver were incubated with Robinson's medium and the oxygen uptake measured for 4 h. 2. Methylguanidine was added to the incubation medium after 1 h to give final concentrations up to four times those found in chronic uraemia. 3. No significant inhibition of oxygen uptake was found at any of the concentrations tested.

Protein kinase C activity, translocation, and selective isoform subcellular redistribution in the rat cerebral cortex after in vitro ischemia

2002 ◽  
Vol 71 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Rita Selvatici ◽  
Silvia Marino ◽  
Carmela Piubello ◽  
Donata Rodi ◽  
Lorenzo Beani ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Cerebral Cortex ◽  
In Vitro Ischemia ◽  
Kinase C ◽  
Protein Kinase C Activity

Oxidative metabolism of incubated cerebral cortex slices from pyridoxine-deficient kittens

1961 ◽  
Vol 200 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Guy M. McKhann ◽  
Olaf Mickelsen ◽  
Donald B. Tower
Keyword(s):  
Cerebral Cortex ◽  
Oxygen Uptake ◽  
Oxidative Metabolism ◽  
Pyridoxal Phosphate ◽  
In Vitro Study ◽  
Aminobutyric Acid ◽  
Shunt Pathway ◽  
Pyridoxine Deficiency ◽  
Cortex Slices

Pyridoxine deficiency was produced in weanling kittens by dietary means. Clinically, the deficient animals showed failure to gain weight, ataxia, and, if left on the diet, seizures and death. In vitro study of isolated cerebral cortex slices from the deficient animals showed decreased formation of γ-aminobutyric acid and decreased oxygen uptake when glucose was the substrate. Addition of pyridoxal phosphate to the incubation media corrected both of these defects toward the levels found in normal littermate controls. The decreased oxygen uptake was also corrected by the addition of γ-aminobutyric acid to the media. It is suggested that in pyridoxine deficiency, cerebral oxidative metabolism is impaired by blockage of the γ-aminobutyric acid ‘shunt’ pathway at the glutamic decarboxylase step. The role of this shunt pathway in normal neuronal metabolism is discussed.

The Influence of Inhalational Anesthetics on In Vivo  and In Vitro  Benzodiazepine Receptor Binding in the Rat Cerebral Cortex

1991 ◽  
Vol 74 (1) ◽  
pp. 97-104 ◽  
Author(s):  
Thomas D. Hansen ◽  
David S. Warner ◽  
Michael M. Todd ◽  
Max T. Baker ◽  
Niels F. Jensen
Keyword(s):  
Cerebral Cortex ◽  
Receptor Binding ◽  
Benzodiazepine Receptor ◽  
Rat Cerebral Cortex ◽  
Inhalational Anesthetics
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